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See Latest ArticlesSecretin-induced gastric relaxation is mediated by vasoactive intestinal polypeptide and prostaglandin pathways
Neurogastroenterology and Motility, 06/18/09
Lu Y et al. - The observations indicate that secretin acts through stimulation of presynaptic cholinergic neurons in a vagally mediated pathway. Through nicotinic synapses, secretin stimulates VIP release from postganglionic neurons in the gastric myenteric plexus, which in turn induces gastric relaxation through a prostaglandin-dependent pathway.
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