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Huang TT et al. - Current levels of obesity reflect complex social changes and biological susceptibilities, and their interactions, during the last 40 years. Individual behaviors such as eating and physical activity do not occur in a vacuum; rather, they are influenced by socioenvironmental factors and by powerful biological processes. Behavior change cannot be sustained if these drivers of behavior are not considered. A systems-oriented, multilevel framework encompassing science and research capacity-building is the way to generate solutions that deal with the complex system in which obesity arises. A multilevel research agenda is cross-disciplinary, bringing together expertise in traditionally disparate fields to pose cross-disciplinary hypotheses and to test those hypotheses collectively. The agenda also would extend conventional research boundaries by tackling structural aspects of the social, physical, and policy environment that affect obesity. Capacity building for global research is critical for sustaining a multilevel research agenda for obesity and chronic disease prevention.

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