Gastro Medical News about Rectal Cancer

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Biomarkers for Response to Neoadjuvant Chemoradiation for Rectal Cancer
International Journal of Radiation Oncology*Biology*Physics, 06/18/09

Kuremsky JG et al. - Thymidylate synthase, when evaluated for polymorphisms in germline DNA, is promising as a predictive biomarker. Ki-67 and bcl-2 are not useful in predicting outcome. p21 needs to be further evaluated to determine its usefulness in predicting outcome. Bax requires more investigation to determine its usefulness. Epidermal growth factor receptor, thymidylate synthase, and p21 should be evaluated in larger prospective clinical trials for their ability to guide preoperative therapy choices in LARC.

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