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Functional Heartburn has more in common with Functional Dyspepsia than with Non-Erosive Reflux Disease
Gut, 06/08/09

Savarino E et al. - Functional dyspepsia (FD) and non-erosive reflux disease (NERD) are prevalent gastrointestinal conditions with accumulating evidence on overlap between the two. The increased prevalence of dyspeptic symptoms in patients with functional heartburn reinforces the concept that functional gastrointestinal disorders extend beyond the boundaries suggested by the anatomical location of symptoms.

Exclusive Author Commentary
Edoardo Savarino, 06/14/09

The present study underscores the important overlap between functional dyspepsia (FD) and Non-erosive reflux disease (NERD). This argues for need to monitor dyspeptic symptoms and characteristics of reflux episodes in patients primarily diagnosed with NERD to help identify the proportion of patients with truly Functional Heartburn, who should rather be included in the overall population with functional GI disorders and should no more considered as a Gastro Oesophageal Reflux Disease subgroup. This deliberate separation should spare these patients from wasteful and protracted courses of years of acid suppression and, above all, prevent potentially disastrous exposure to surgical options. This possible redefinition might impact epidemiology, pathophysiology and natural history of the respective disorders.

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