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See Latest ArticlesGermline CDH1 deletions in hereditary diffuse gastric cancer families
Human Molecular Genetics, 04/16/09
Oliveira C et al. - The authors hypothesized that CDH1 genomic rearrangements would be found in HDGC and identified 160 families with either two gastric cancers in first-degree relatives and with at least one diffuse gastric cancer (DGC) diagnosed before age 50, or three or more DGC in close relatives diagnosed at any age. As the finding of pathogenic CDH1 mutations is useful for management of HDGC families, screening for deletions should be offered to at-risk families.
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