Evaluation of Prokinetic Action of Clarithromycin using Orocecal Transit Time in Healthy Human Subjects
Shobha JC et al. - The prokinetic action of clarithromycin is substantiated in this study as it significantly reduced OTT as compared to placebo and loperamide. Sulfapyridine lag time in saliva and hence OTT were significantly reduced by clarithromycin indicating its prokinetic effect like erythromycin. However, the clinical utility of this decrease in the lag time has to be evaluated in further studies before any therapeutic indication can be recommended. [more...]
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