Preoperative thrombocytosis is associated with survival after surgery for colorectal cancer
Journal of Surgical Oncology, 05/25/2012
Ishizuka M et al. – Preoperative thrombocytosis is associated with survival after surgery in CRC patients, and is able to divide such patients into two independent groups before surgery.Methods
- Four hundred fifty–three patients who had undergone CRC surgery were retrospectively identified from institutional database.
- On the basis of receiver operating characteristic (ROC) curve analysis, they were classified into two groups: Group A, with a preoperative platelet count of ≤300 (×109/L), and Group B, with a preoperative platelet count of >300 (×109/L).
- Uni– and multivariate analyses were performed to evaluate the relationship to overall survival. Kaplan–Meier analysis and log rank test were used to compare the survival curves between groups A and B.
- There was a significant difference in overall survival between the two groups (P=0.007).
- Multivariate analysis of selected preoperative clinicolaboratory characteristics showed that overall survival was associated with the platelet count (Group A/B) (odds ratio, 1.642; 95% CI, 1.025–2.629; P=0.039) as well as the number of tumors (1/≥2), and the serum levels of C–reactive protein (CRP) and carcinoembryonic antigen (CEA).