Impact and prognostic implications of colon cancers stage II sub-classification through the years
International Journal of Colorectal Disease, 05/31/2012
Lorenzon L et al. – The American Joint Committee on Cancer (AJCC) 7th edition is a reliable classification that might implement the identification of those stage II colon cancer patients with high–risk of progression, recurrence, and cancer mortality.Methods
- One hundred seventy-eight stage II colon cancers out of 682 colorectal cancer patients who underwent surgical resection were selected.
- T4N0 were sub-divided in accordance with the AJCC 7th edition.
- Mean follow-up was 41.9 months.
- Kaplan-Meier method was employed to estimate the survival curves.
- OS analysis documented a significant difference between stage-sub-groups using the 6th edition; conversely, this difference was not seen if the 7th edition was applied (p=0.03 and 0.12, respectively).
- Stage II DFS analysis reported a significant difference using both the AJCC 6th and 7th editions (p=0.03 and 0.02, respectively).
- A significant difference was reported on stage II DSS analysis using the AJCC 6th edition (p=0.03); however, when the 7th edition was applied, a substantial discrepancy between survival curves was noted with T3N0 and T4aN0 displaying similar outcomes (p=0.006).