Prenatal and Perinatal Characteristics Associated with Pediatric-Onset Inflammatory Bowel Disease

Digestive Diseases and Sciences, 04/13/2012

Maternal history of inflammatory bowel disease (IBD) and race were the only characteristics of those that the authors examined that were associated with the development of pediatric IBD in this well–documented population of cases and matched controls.

Methods

  • The authors conducted a nested case–control study of 189 cases aged ≤18 years and 3,080 age- and membership-matched controls born at a Kaiser Permanente Northern California facility between 1984 and 2006.
  • The cases were diagnosed with IBD between 1996 and 2006 and diagnosis was confirmed by chart review.
  • They obtained prenatal and perinatal characteristics from the electronic clinical records of the mother and child.
  • Conditional logistic regression was used to assess the associations between these factors and risk of incident IBD, Crohn’s disease, and ulcerative colitis.

Results

  • In analyses accounting for confounding, maternal IBD (odds ratio [OR] 5.1, 95 % confidence interval [CI] 2.0-12.9) and white race (OR 2.3, 95 % CI 1.6-3.2) were the only factors statistically associated with pediatric-onset IBD.
  • Maternal respiratory infection during pregnancy (OR 2.0, 95 % CI 1.0–4.0), age < 20 years (OR 2.0, 95 % CI 0.8-4.7) and gestational hypertension (OR 1.7, 95 % CI 1.0–2.7) were associated with pediatric-onset IBD, but did not achieve statistical significance.

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