Topical agents for Idiopathic Distal Colitis and Proctitis
Journal of Gastroenterology and Hepatology, 09/07/2010
Lawrance IC – Novel topical agents have been proposed for the management of resistant distal colitis. These agents included butyrate, cyclosporine, and nicotine enemas, as well as tacrolimus suppositories, and tacrolimus, ecabet sodium, arsenic, lidocaine, bismuth, rebamipide and thromboxane enemas. While some of these agents appear to demonstrate impressive outcomes, the majority has only been examined in small open–labelled studies. There is thus a desperate need for more randomized double–blinded placebo controlled studies to investigate the clinical utility of these topical therapies. This review summaries the efficacy of the established topical therapies, and explores the available data on the new and novel topical agents for the management of DC and proctitis.