Corticosteroids Modulate Angiogenic Soluble Factors in Ulcerative Colitis Patients
Digestive Diseases and Sciences, 07/26/2010
Pousa ID et al. – VEGF, Ang1, and Ang2 levels showed statistically significant differences between UC patients and healthy controls. Although determination of PlGF serum levels before corticosteroid treatment might be helpful to anticipate the response by UC patients, no angiogenic pattern that could accurately predict “a priori” this response to corticosteroid treatment was observed. Corticosteroids altered temporarily circulating levels of VEGF, angiopoietins and Tie2. No correlation was found between systemic levels of angiogenic factors and the clinical activity of UC.