Quantitative Assessment and Characterization of Visceral Hyperalgesia Evoked by Esophageal Balloon Distention and Acid Perfusion in Patients With Functional Heartburn, Nonerosive Reflux Disease, and Erosive Esophagitis

The Clinical Journal of Pain, 04/16/2010

Functional heartburn (FH) patients are more sensitive to mechanical or chemical stimuli than NERD patients. Sensitization of esophageal acid–sensitive chemoreceptors may exert a significant influence on the pressure–sensitive mechanoreceptors, and there is the cooperative interaction in the process of esophageal visceral hyperalgesia.

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