Helicobacter Pylori Infection Increases the Risk of Colorectal Adenomas: Cross-Sectional Study and Meta-Analysis
Digestive Diseases and Sciences, 06/22/2012

Hong SN et al. – The results from this cross–sectional study and current studies included in the meta–analysis indicated that H. pylori infection was associated with a modest increase in the risk for colorectal adenoma.

• This cross–sectional study investigated the association of colorectal adenoma with H. pylori infection in a consecutive series of 2,195 asymptomatic average–risk subjects who underwent screening colonoscopy and H. pylori testing.
• Multivariate analyses were adjusted for potential relevant confounders, including age, sex, smoking, alcohol consumption, family history of colorectal cancer, and regular use of aspirin.
• Furthermore, the authors performed a systematic literature review and meta–analysis of available studies, including the current study, to clarify whether H. pylori infection is associated with an increased risk of colorectal adenoma.

• Among 2,195 eligible subjects, 1,253 subjects were H. pylori seropositive and 942 subjects were seronegative.
• In the H. pylori (+) group, the prevalence of colorectal adenoma and advanced adenoma was significantly higher than in the H. pylori (–) group (25.3 vs. 20.1 %, p=0.004 and 6.1 vs. 2.9 %, p<0.001, respectively).
• In the multivariate analysis, H. pylori seropositivity was an independent risk factor for overall colorectal adenoma (OR=1.36, 95 % CI=1.10–1.68) and advanced adenoma (OR=2.21, 95 % CI=1.41–3.48).
• The positive association was confined in cases with any proximal adenoma.
• In the meta–analysis, which included ten studies and 15,863 patients, the pooled OR for colorectal adenoma related to H. pylori infection was 1.58 (95 % CI=1.32–1.88).