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Gastroenterology - Pharmacology/kinetics News & Articles

Available now at MDLinx Gastroenterology: Ranked summaries of the most clinically-relevant GI literature refreshed every 24 hours, as well as MDLinx Gastroenterology exclusive content

  • Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in your uniquely diverse field. In addition to general gastroenterology news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.
  • MDLinx Gastroenterology exclusive content includes: Monthly highlights of the "can't miss" articles chosen by our physician editor, D. Scott Cunningham, MD, PhD; clinical pearls from The Smartest Internist and Smartest Family Physician daily competitions, a collaboration from the editors of MDLinx and Cleveland Clinic Center for Continuing Education; and pearls from our Pediatrics Physician Review quizzes.

Your Unread Messages in Gastroenterology

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Articles

Latest (6) Full Text Articles (194)
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

1 Proton pump inhibitors for eosinophilic oesophagitis Current Opinion in Gastroenterology, June 19, 2013    Clinical Article

2 Antiplatelet drugs are a risk factor for esophageal mucosal injury Digestion, June 19, 2013    Clinical Article

3 Reasons for avoidance of bevacizumab with first-line FOLFOX for advanced colorectal cancer International Journal of Clinical Oncology, June 19, 2013    Clinical Article

4 Combination phase II study of weekly paclitaxel and 5'-DFUR for unresectable or recurrent gastric cancer Anticancer Research, June 19, 2013    Clinical Article

5 Therapeutic targeting of CPT-11 induced diarrhea: a case for prophylaxis Current Drug Targets, June 19, 2013    Review Article

6 Trends of second-line eradication therapy for helicobacter pylori in Japan: a multicenter study in the Tokyo metropolitan area Helicobacter, June 19, 2013    Clinical Article

Prior Articles

7 Chronic hepatitis B: a treatment update Seminars in Liver Disease, June 18, 2013    Clinical Article

8 Drug-induced liver injury caused by intravenously administered medications: the drug-induced liver injury network experience Journal of Clinical Gastroenterology, June 18, 2013    Clinical Article

9 Treatment options for esophageal squamous cell carcinoma Expert Opinion on Pharmacotherapy, June 18, 2013    Review Article

10 Prognostic impact of tumor IL-6 expression after preoperative chemoradiotherapy in patients with advanced esophageal squamous cell carcinoma Anticancer Research, June 18, 2013    Clinical Article

11 Induction therapy with alemtuzumab (campath) in combined liver-kidney transplantation: University of Bologna experience Transplantation Proceedings, June 18, 2013    Clinical Article

12 Conversion to prolonged-release tacrolimus for pediatric living related donor liver transplant recipients Transplantation Proceedings, June 18, 2013    Clinical Article

13 Accidental acetaminophen overdose results in liver transplant during second trimester of pregnancy: a case report Transplantation Proceedings, June 18, 2013    Clinical Article

14 Intermittent treatment with mesalazine in the prevention of diverticulitis recurrence: a randomised multicentre pilot double-blind placebo-controlled study of 24-month duration International Journal of Colorectal Disease, June 17, 2013    Clinical Article

15 Antiviral therapy for chronic hepatitis B in pregnancy Seminars in Liver Disease, June 17, 2013    Clinical Article

16 Epidermal growth factor receptor (EGFR) and KRAS mutations during chemotherapy plus anti-EGFR monoclonal antibody treatment in metastatic colorectal cancer Cancer Chemotherapy and Pharmacology, June 17, 2013    Clinical Article

17 Effects of remifentanil on the esophagogastric junction and swallowing Acta Anaesthesiologica Scandinavica, June 17, 2013    Clinical Article

18 Moving towards disease modification in inflammatory bowel disease therapy Current Opinion in Gastroenterology, June 17, 2013    Clinical Article

19 Safety, tolerability, pharmacokinetics, and pharmacodynamics of a long-acting release (LAR) formulation of pasireotide (SOM230) in patients with gastroenteropancreatic neuroendocrine tumors: results from a randomized, multicenter, open-label, phase I study Cancer Chemotherapy and Pharmacology, June 17, 2013    Clinical Article

20 Randomized phase II study of gemcitabine plus s-1 vs. s-1 in advanced biliary tract cancer (jcog0805) Cancer Science, June 17, 2013    Clinical Article

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Clinical Pearls in Gastroenterology

Highlights in Gastroenterology

What is the best strategy for CRC screening?

As published in the NEJM, researchers in the COLONPREV study (Spain) have reported that fecal immunochemical testing (FIT) is as effective as colonoscopy in the detection of colorectal cancer (CRC). The study population was 50-69 years of age and comprised of 26,703 subjects who underwent a one-time colonoscopy and 26,599 subjects who underwent FIT every 2 years. The primary outcome measure was CRC deaths at 10 years. Participation in screening was greater in the FIT group than the colonoscopy group (34.2% vs. 24.6%). Detection of CRC was similar between the two groups (0.1%). Advanced and non-advanced adenomas were detected more frequently in the colonoscopy group than the FIT group (1.9% vs. 0.9% [OR=2.3] and 4.2% vs. 0.4% [OR=9.8], respectively).

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PPIs increase risk of Clostridium difficile infection

Based on a meta-analysis involving 30 observational studies and 202,965 patients, proton pump inhibitor therapy has been shown to significantly increase the risk of infection with Clostridium difficile (OR = 2.15).

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Metformin improves survival in patients with DM and CRC

In a single institution study involving 424 patients with DM and CRC, those patients treated with metformin had a 30% improvement in OS compared with patients not treated with metformin. Specifically, the metformin-treated patients had a mean survival of 76.9 months compared to 56.9 months.

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Most Popular Gastro Articles

Last month's top read Top Articles of 2012

1 Preventive effect of irsogladine or omeprazole on non-steroidal anti-inflammatory drug-induced esophagitis, peptic ulcers, and small intestinal lesions in humans, a prospective randomized controlled study BMC Gastroenterology, May 15, 2013    Free full text

2 Pilot study: miscellaneous therapy is highly successful for Helicobacter pylori eradication Alimentary Pharmacology and Therapeutics, May 10, 2013

3 A comparison of efficacy and safety of 2-year telbivudine and entecavir treatment in patients with chronic hepatitis B: a match-control study Clinical Microbiology and Infection, May 13, 2013

4 Chronic use of PPI and h2 antagonists decreases the risk of pouchitis after IPAA for Ulcerative Colitis Journal of Gastrointestinal Surgery, May 24, 2013

5 Association of Nox1 and vinculin with colon cancer progression Cancer Investigation, May 22, 2013

6 Rates of pharmacologic venous thromboembolism prophylaxis in hospitalized patients with active ulcerative colitis: Results from a tertiary care center Journal of Crohn's and Colitis, May 28, 2013

7 Early increase in α-fetoprotein for predicting unfavorable clinical outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib European Journal of Gastroenterology & Hepatology, May 7, 2013

8 Proton Pump Inhibitor Use and the Risk of Small Intestinal Bacterial Overgrowth: A Meta-analysis Clinical Gastroenterology and Hepatology , April 23, 2013

9 Clinical characteristics and effectiveness of lansoprazole in Japanese patients with gastroesophageal reflux disease and dyspepsia Journal of Gastroenterology, May 8, 2013

10 Radiotherapy in the Management of Pancreatic Neuroendocrine Tumors (PNET): Experience at Three Institutions Anticancer Research, May 7, 2013

11 Ischemic Colitis with Type I Interferons Used in the Treatment of Hepatitis C and Multiple Sclerosis: An Evaluation from the Food and Drug Administration Adverse Event Reporting System and Review of the Literature Annals of Pharmacotherapy, April 3, 2013    Review Article

12 Risk of Gastrointestinal Bleeding in Patients Undergoing Total Hip or Knee Replacement Compared With Matched Controls: A Nationwide Cohort Study The American Journal of Gastroenterology, May 2, 2013

13 Plecanatide, an Oral Guanylate Cyclase C Agonist Acting Locally in the Gastrointestinal Tract, Is Safe and Well-Tolerated in Single Doses Digestive Diseases and Sciences, May 9, 2013

14 B-Cell Depletion With Rituximab in Patients With Primary Biliary Cirrhosis Refractory to Ursodeoxycholic Acid The American Journal of Gastroenterology, May 8, 2013

15 Clinical evaluation of a ten-day regimen with esomeprazole, metronidazole, amoxicillin, and clarithromycin for the eradication of Helicobacter pylori in a high clarithromycin resistance area Helicobacter, May 30, 2013

16 Cyclo-oxygenase-2 inhibitors or nonselective NSAIDs plus gastroprotective agents: what to prescribe in daily clinical practice Alimentary Pharmacology and Therapeutics, May 29, 2013

17 Treatment for H. pylori Infection: New Challenges With Antimicrobial Resistance Journal of Clinical Gastroenterology, April 11, 2013

18 Management of difficult-to-treat patients with ulcerative colitis: focus on adalimumab Drug Design, Development and Therapy, April 10, 2013    Free full text

19 Liquid nitrogen spray cryotherapy in Barretts esophagus with high-grade dysplasia: long-term results Gastrointestinal Endoscopy, May 9, 2013

20 Renal tubular dysfunction during long-term adefovir or tenofovir therapy in chronic hepatitis B Alimentary Pharmacology and Therapeutics, April 24, 2012

Indexed Journals in Gastroenterology: Gastroenterology, American Journal of Gastroenterology, Gutmore

Other Topics in Gastroenterology

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