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Gastroenterology - Pharmacology/kinetics News & Articles

Available now at MDLinx Gastroenterology: Ranked summaries of the most clinically-relevant GI literature refreshed every 24 hours, as well as MDLinx Gastroenterology exclusive content

  • Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in your uniquely diverse field. In addition to general gastroenterology news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.
  • MDLinx Gastroenterology exclusive content includes: Monthly highlights of the "can't miss" articles chosen by our physician editor, D. Scott Cunningham, MD, PhD; clinical pearls from The Smartest Internist and Smartest Family Physician daily competitions, a collaboration from the editors of MDLinx and Cleveland Clinic Center for Continuing Education; and pearls from our Pediatrics Physician Review quizzes.

Your Unread Messages in Gastroenterology

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Articles

Latest (4) Full Text Articles (194)
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

161 Toxicity of Bevacizumab in Combination with Chemotherapy in Older Patients Full Text The Oncologist, April 12, 2013    Clinical Article

162 Differences in utilisation of gastroprotective drugs between 2001 and 2005 in Australia and Nova Scotia, Canada Pharmacoepidemiology and Drug Safety, April 12, 2013    Review Article

163 Treatment for H. pylori Infection: New Challenges With Antimicrobial Resistance Journal of Clinical Gastroenterology, April 11, 2013    Clinical Article

164 Meta-analysis: silymarin and its combination therapy for the treatment of chronic hepatitis B European Journal of Clinical Microbiology & Infectious Diseases, April 11, 2013    Evidence Based Medicine    Clinical Article

165 Reflux episodes detected by impedance in patients on and off esomeprazole: a randomised double-blinded placebo-controlled crossover study Alimentary Pharmacology and Therapeutics, April 11, 2013    Clinical Article

166 Effect of a Preoperative Gabapentin on Postoperative Analgesia in Patients with Inflammatory Bowel Disease Following Major Bowel Surgery: A Randomized, Placebo-Controlled Trial Pain Practice, April 11, 2013    Clinical Article

167 Adenosine kinase is a key determinant for the anti-HCV activity of ribavirin Hepatology, April 11, 2013    Review Article

168 A real-life experience using panitumumab in chemo-refractory metastatic colorectal cancer patients: a retrospective analysis at the Jewish General Hospital, 2009-2012 Full Text Current Oncology, April 11, 2013    Clinical Article

169 Antacid-Induced Acute Pancreatitis The Consultant Pharmacist, April 11, 2013

170 Epidural vs. intravenous fentanyl during colorectal surgery using a double-blind, double-dummy design Acta Anaesthesiologica Scandinavica, April 11, 2013    Clinical Article

171 Evaluation of Pharmacologic Prophylaxis for Venous Thromboembolism in Patients with Chronic Liver Disease Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, April 11, 2013    Clinical Article

172 Treatment of chronic hepatitis C infection among current and former injection drug users within a multidisciplinary treatment model at a community health centre, Canadian Journal of Gastroenterology, April 10, 2013    Clinical Article

173 Management of difficult-to-treat patients with ulcerative colitis: focus on adalimumab Full Text Drug Design, Development and Therapy, April 10, 2013    Clinical Article

174 Risk factors for anastomotic leakage and favorable antimicrobial treatment as empirical therapy for intra-abdominal infection in patients undergoing colorectal surgery Surgery Today, April 10, 2013    Clinical Article

175 Shugoshin1 enhances multidrug resistance of gastric cancer cells by regulating MRP1, Bcl-2, and Bax genes Tumor Biology, April 10, 2013    Clinical Article

176 Prevention of De Novo Hepatitis B in Recipients of Core Antibody-Positive Livers With Lamivudine and Other Nucleos(t)ides: A 12-Year Experience Transplantation, April 10, 2013    Clinical Article

177 Adalimumab combined with ciprofloxacin is superior to adalimumab monotherapy in perianal fistula closure in Crohns disease: a randomised, double-blind, placebo controlled trial (ADAFI) Gut, April 9, 2013    Clinical Article

178 Role of hepatitis C virus substitutions and interleukin-28B polymorphism on response to peginterferon plus ribavirin in a prospective study of response-guided therapy Journal of Viral Hepatitis, April 9, 2013    Clinical Article

179 Normal Values of Pharyngeal and Esophageal 24-Hour pH Impedance in Individuals on and off Therapy and Interobserver Reproducibility Clinical Gastroenterology and Hepatology , April 9, 2013    Clinical Article

180 Sunitinib malate for the treatment of pancreas malignancies where does it fit? Expert Opinion on Pharmacotherapy, April 9, 2013    Clinical Article

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Clinical Pearls in Gastroenterology

Highlights in Gastroenterology

What is the best strategy for CRC screening?

As published in the NEJM, researchers in the COLONPREV study (Spain) have reported that fecal immunochemical testing (FIT) is as effective as colonoscopy in the detection of colorectal cancer (CRC). The study population was 50-69 years of age and comprised of 26,703 subjects who underwent a one-time colonoscopy and 26,599 subjects who underwent FIT every 2 years. The primary outcome measure was CRC deaths at 10 years. Participation in screening was greater in the FIT group than the colonoscopy group (34.2% vs. 24.6%). Detection of CRC was similar between the two groups (0.1%). Advanced and non-advanced adenomas were detected more frequently in the colonoscopy group than the FIT group (1.9% vs. 0.9% [OR=2.3] and 4.2% vs. 0.4% [OR=9.8], respectively).

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PPIs increase risk of Clostridium difficile infection

Based on a meta-analysis involving 30 observational studies and 202,965 patients, proton pump inhibitor therapy has been shown to significantly increase the risk of infection with Clostridium difficile (OR = 2.15).

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Metformin improves survival in patients with DM and CRC

In a single institution study involving 424 patients with DM and CRC, those patients treated with metformin had a 30% improvement in OS compared with patients not treated with metformin. Specifically, the metformin-treated patients had a mean survival of 76.9 months compared to 56.9 months.

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Most Popular Gastroenterology Articles

Last month's top read Top Articles of 2012

1 Ischemic Colitis with Type I Interferons Used in the Treatment of Hepatitis C and Multiple Sclerosis: An Evaluation from the Food and Drug Administration Adverse Event Reporting System and Review of the Literature Annals of Pharmacotherapy, April 3, 2013    Review Article

2 Treatment for H. pylori Infection: New Challenges With Antimicrobial Resistance Journal of Clinical Gastroenterology, April 11, 2013

3 Efficacy of Two Levofloxacin-Containing Second-Line Therapies for Helicobacter pylori: A Pilot Study Helicobacter, April 24, 2013

4 The effect of Helicobacter pylori infection and eradication in patients with gastro-oesophageal reflux disease: A parallel-group, double-blind, placebo-controlled multicentre study United European Gastroenterology Journal, April 1, 2013

5 Management of difficult-to-treat patients with ulcerative colitis: focus on adalimumab Drug Design, Development and Therapy, April 10, 2013    Free full text

6 Incidence of Campylobacter and Salmonella Infections Following First Prescription for PPI: A Cohort Study Using Routine Data The American Journal of Gastroenterology, April 17, 2013

7 Propofol for Pediatric Colonoscopy: The Experience of a Large, Tertiary Care Pediatric Hospital American Journal of Therapeutics, April 15, 2013

8 Adalimumab combined with ciprofloxacin is superior to adalimumab monotherapy in perianal fistula closure in Crohns disease: a randomised, double-blind, placebo controlled trial (ADAFI) Gut, April 9, 2013

9 Impact of oral silymarin on virus- and non-virus-specific T-cell responses in chronic hepatitis C infection Journal of Viral Hepatitis, April 16, 2013

10 Dysmotility and proton pump inhibitor use are independent risk factors for small intestinal bacterial and/or fungal overgrowth Alimentary Pharmacology and Therapeutics, April 15, 2013

11 Dual oral therapy with daclatasvir and asunaprevir for patients with HCV genotype 1b infection and limited treatment options Journal of Hepatology, April 2, 2013

12 Clinical utility of newly developed immunoassays for serum concentrations of adalimumab and anti-adalimumab antibodies in patients with Crohns disease Journal of Gastroenterology, April 15, 2013

13 Long term benefit of one year infliximab administration for the treatment of chronic refractory pouchitis Journal of Crohn's and Colitis, April 5, 2013

14 Cost-per-remission analysis of infliximab compared to adalimumab among adults with moderate-to-severe ulcerative colitis Journal of Medical Economics , April 16, 2013    Review Article

15 Anti-Tumor Necrosis Factor Therapy Is Associated With Infections after Abdominal Surgery in Crohn's Disease Patients The American Journal of Gastroenterology, March 19, 2013

16 Diagnostic difficulties, therapeutic strategies, and performance of scoring systems in patients with autoimmune hepatitis and concurrent hepatitis B/C Scandinavian Journal of Gastroenterology, April 17, 2013

17 Randomised clinical trial: macrogol/PEG 3350+electrolytes versus prucalopride in the treatment of chronic constipation - a comparison in a controlled environment Alimentary Pharmacology and Therapeutics, March 20, 2013

18 Infliximab versus cyclosporine as rescue therapy in acute severe steroid-refractory ulcerative colitis: a systematic review and meta-analysis International Journal of Colorectal Disease, March 18, 2013    Evidence Based Medicine    Review Article
Exclusive Author Commentary

19 Comparison Between Botulinum Injection and Removable Covered Self-Expanding Metal Stents for the Treatment of Achalasia Digestive Diseases and Sciences, February 28, 2013

20 Pharmacology and clinical potential of guanylyl cyclase C agonists in the treatment of ulcerative colitis Drug Design, Development and Therapy, April 26, 2013    Free full text    Review Article

Indexed Journals in Gastroenterology: Gastroenterology, American Journal of Gastroenterology, Gutmore

Other Topics in Gastroenterology

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