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Gastroenterology - Pharmacology/kinetics News & Articles

Available now at MDLinx Gastroenterology: Ranked summaries of the most clinically-relevant GI literature refreshed every 24 hours, as well as MDLinx Gastroenterology exclusive content

  • Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in your uniquely diverse field. In addition to general gastroenterology news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.
  • MDLinx Gastroenterology exclusive content includes: Monthly highlights of the "can't miss" articles chosen by our physician editor, D. Scott Cunningham, MD, PhD; clinical pearls from The Smartest Internist and Smartest Family Physician daily competitions, a collaboration from the editors of MDLinx and Cleveland Clinic Center for Continuing Education; and pearls from our Pediatrics Physician Review quizzes.

Your Unread Messages in Gastroenterology

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Articles

Latest (7) Full Text Articles (194)
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

141 Sorafenib in Combination with Oxaliplatin, Leucovorin, and Fluorouracil (Modified FOLFOX6) as First-line Treatment of Metastatic Colorectal Cancer: The RESPECT Trial Clinical Cancer Research, April 18, 2013    Clinical Article

142 A randomized, double-blinded, placebo-controlled, multicenter trial, healing effect of rebamipide in patients with low-dose aspirin and/or non-steroidal anti-inflammatory drug induced small bowel injury Journal of Gastroenterology, April 18, 2013    Clinical Article

143 Association between adherence to concomitant proton pump inhibitor therapy in current NSAID users and upper gastrointestinal complications European Journal of Gastroenterology & Hepatology, April 18, 2013    Clinical Article

144 A UGT1A1*28 and *6 genotype-directed phase I dose-escalation trial of irinotecan with fixed-dose capecitabine in Korean patients with metastatic colorectal cancer Cancer Chemotherapy and Pharmacology, April 18, 2013    Clinical Article

145 Diagnostic difficulties, therapeutic strategies, and performance of scoring systems in patients with autoimmune hepatitis and concurrent hepatitis B/C Scandinavian Journal of Gastroenterology, April 17, 2013    Clinical Article

146 Incidence of Campylobacter and Salmonella Infections Following First Prescription for PPI: A Cohort Study Using Routine Data The American Journal of Gastroenterology, April 17, 2013    Clinical Article

147 Efficacy, safety, and pharmacokinetics of imatinib dose escalation to 800mg/day in patients with advanced gastrointestinal stromal tumors Investigational New Drugs, April 17, 2013    Clinical Article

148 Colorectal cancer stem cells and their implications for novel anticancer therapy Expert Review of Anticancer Therapy, April 17, 2013    Clinical Article

149 Cost-per-remission analysis of infliximab compared to adalimumab among adults with moderate-to-severe ulcerative colitis Journal of Medical Economics , April 16, 2013    Review Article

150 Impact of oral silymarin on virus- and non-virus-specific T-cell responses in chronic hepatitis C infection Journal of Viral Hepatitis, April 16, 2013    Clinical Article

151 Effect of Fluoroquinolone Resistance on 14-day Levofloxacin Triple and Triple Plus Bismuth Quadruple Therapy Helicobacter, April 16, 2013    Clinical Article

152 Safety of a Novel Parenteral Formulation of Diclofenac after Major Orthopedic or Abdominal/Pelvic Surgery in a Population Including Anticoagulated, Elderly or Renally Insufficient Patients: An Open-Label, Multiday, Repeated Dose Clinical Trial Pain Medicine, April 16, 2013    Clinical Article

153 Colorectal Cancer Surgery in Portal Hypertensive Patients: Does Adjuvant Oxaliplatin Affect Prognosis? Diseases of the Colon and Rectum, April 16, 2013    Clinical Article

154 Critical appraisal of the use of regorafenib in the management of colorectal cancer Full Text Cancer Management and Research, April 16, 2013    Clinical Article

155 Clinical utility of newly developed immunoassays for serum concentrations of adalimumab and anti-adalimumab antibodies in patients with Crohns disease Journal of Gastroenterology, April 15, 2013    Clinical Article

156 Neutropenia During Therapy with Peginterferon and Ribavirin in HIV-Infected Subjects with Chronic Hepatitis C and the Risk of Infections Clinical Infectious Diseases, April 15, 2013    Clinical Article

157 Assessment of response to sorafenib in advanced hepatocellular carcinoma using perfusion computed tomography: Results of a pilot study Digestive and Liver Diseases, April 15, 2013    Clinical Article

158 Dysmotility and proton pump inhibitor use are independent risk factors for small intestinal bacterial and/or fungal overgrowth Alimentary Pharmacology and Therapeutics, April 15, 2013    Clinical Article

159 A Phase II Randomized Dose Escalation Trial of Sorafenib in Patients With Advanced Hepatocellular Carcinoma Full Text The Oncologist, April 15, 2013    Clinical Article

160 Multicenter Phase II Study of Tivozanib (AV-951) and Everolimus (RAD001) for Patients With Refractory, Metastatic Colorectal Cancer Full Text The Oncologist, April 15, 2013    Clinical Article

50 available pages First Previous 8 9 10 11 12 13 14 15 16 17 Next Last

Clinical Pearls in Gastroenterology

Highlights in Gastroenterology

What is the best strategy for CRC screening?

As published in the NEJM, researchers in the COLONPREV study (Spain) have reported that fecal immunochemical testing (FIT) is as effective as colonoscopy in the detection of colorectal cancer (CRC). The study population was 50-69 years of age and comprised of 26,703 subjects who underwent a one-time colonoscopy and 26,599 subjects who underwent FIT every 2 years. The primary outcome measure was CRC deaths at 10 years. Participation in screening was greater in the FIT group than the colonoscopy group (34.2% vs. 24.6%). Detection of CRC was similar between the two groups (0.1%). Advanced and non-advanced adenomas were detected more frequently in the colonoscopy group than the FIT group (1.9% vs. 0.9% [OR=2.3] and 4.2% vs. 0.4% [OR=9.8], respectively).

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PPIs increase risk of Clostridium difficile infection

Based on a meta-analysis involving 30 observational studies and 202,965 patients, proton pump inhibitor therapy has been shown to significantly increase the risk of infection with Clostridium difficile (OR = 2.15).

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Metformin improves survival in patients with DM and CRC

In a single institution study involving 424 patients with DM and CRC, those patients treated with metformin had a 30% improvement in OS compared with patients not treated with metformin. Specifically, the metformin-treated patients had a mean survival of 76.9 months compared to 56.9 months.

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Most Popular Gastroenterology Articles

Last month's top read Top Articles of 2012

1 Ischemic Colitis with Type I Interferons Used in the Treatment of Hepatitis C and Multiple Sclerosis: An Evaluation from the Food and Drug Administration Adverse Event Reporting System and Review of the Literature Annals of Pharmacotherapy, April 3, 2013    Review Article

2 Treatment for H. pylori Infection: New Challenges With Antimicrobial Resistance Journal of Clinical Gastroenterology, April 11, 2013

3 Efficacy of Two Levofloxacin-Containing Second-Line Therapies for Helicobacter pylori: A Pilot Study Helicobacter, April 24, 2013

4 The effect of Helicobacter pylori infection and eradication in patients with gastro-oesophageal reflux disease: A parallel-group, double-blind, placebo-controlled multicentre study United European Gastroenterology Journal, April 1, 2013

5 Management of difficult-to-treat patients with ulcerative colitis: focus on adalimumab Drug Design, Development and Therapy, April 10, 2013    Free full text

6 Incidence of Campylobacter and Salmonella Infections Following First Prescription for PPI: A Cohort Study Using Routine Data The American Journal of Gastroenterology, April 17, 2013

7 Propofol for Pediatric Colonoscopy: The Experience of a Large, Tertiary Care Pediatric Hospital American Journal of Therapeutics, April 15, 2013

8 Adalimumab combined with ciprofloxacin is superior to adalimumab monotherapy in perianal fistula closure in Crohns disease: a randomised, double-blind, placebo controlled trial (ADAFI) Gut, April 9, 2013

9 Impact of oral silymarin on virus- and non-virus-specific T-cell responses in chronic hepatitis C infection Journal of Viral Hepatitis, April 16, 2013

10 Dysmotility and proton pump inhibitor use are independent risk factors for small intestinal bacterial and/or fungal overgrowth Alimentary Pharmacology and Therapeutics, April 15, 2013

11 Dual oral therapy with daclatasvir and asunaprevir for patients with HCV genotype 1b infection and limited treatment options Journal of Hepatology, April 2, 2013

12 Clinical utility of newly developed immunoassays for serum concentrations of adalimumab and anti-adalimumab antibodies in patients with Crohns disease Journal of Gastroenterology, April 15, 2013

13 Long term benefit of one year infliximab administration for the treatment of chronic refractory pouchitis Journal of Crohn's and Colitis, April 5, 2013

14 Cost-per-remission analysis of infliximab compared to adalimumab among adults with moderate-to-severe ulcerative colitis Journal of Medical Economics , April 16, 2013    Review Article

15 Anti-Tumor Necrosis Factor Therapy Is Associated With Infections after Abdominal Surgery in Crohn's Disease Patients The American Journal of Gastroenterology, March 19, 2013

16 Diagnostic difficulties, therapeutic strategies, and performance of scoring systems in patients with autoimmune hepatitis and concurrent hepatitis B/C Scandinavian Journal of Gastroenterology, April 17, 2013

17 Randomised clinical trial: macrogol/PEG 3350+electrolytes versus prucalopride in the treatment of chronic constipation - a comparison in a controlled environment Alimentary Pharmacology and Therapeutics, March 20, 2013

18 Infliximab versus cyclosporine as rescue therapy in acute severe steroid-refractory ulcerative colitis: a systematic review and meta-analysis International Journal of Colorectal Disease, March 18, 2013    Evidence Based Medicine    Review Article
Exclusive Author Commentary

19 Comparison Between Botulinum Injection and Removable Covered Self-Expanding Metal Stents for the Treatment of Achalasia Digestive Diseases and Sciences, February 28, 2013

20 Pharmacology and clinical potential of guanylyl cyclase C agonists in the treatment of ulcerative colitis Drug Design, Development and Therapy, April 26, 2013    Free full text    Review Article

Indexed Journals in Gastroenterology: Gastroenterology, American Journal of Gastroenterology, Gutmore

Other Topics in Gastroenterology

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