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Gastroenterology - Basic Science/Genetics News & Articles
Available now at MDLinx Gastroenterology: Ranked summaries of the most clinically-relevant GI literature refreshed every 24 hours, as well as MDLinx Gastroenterology exclusive content
- Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in your uniquely diverse field. In addition to general gastroenterology news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.
- MDLinx Gastroenterology exclusive content includes: Monthly highlights of the "can't miss" articles chosen by our physician editor, D. Scott Cunningham, MD, PhD; clinical pearls from The Smartest Internist and Smartest Family Physician daily competitions, a collaboration from the editors of MDLinx and Cleveland Clinic Center for Continuing Education; and pearls from our Pediatrics Physician Review quizzes.
Your Unread Messages in Gastroenterology
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Articles
Latest (1) Full Text Articles (206)981 Hepatitis C Virus NS2 Coordinates Virus Particle Assembly through Physical Interactions with the E1-E2 Glycoprotein and NS3-NS4A Enzyme Complexes Journal of Virology, January 26, 2011
982 Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population Gut, January 25, 2011
983 N-myc downstream regulated gene-1 expression correlates with reduced pancreatic cancer growth and increased apoptosis in vitro and in vivo Surgery, January 25, 2011
984 Downregulation of the hedgehog receptor PTCH1 in colorectal serrated adenocarcinomas is not caused by PTCH1 mutations Virchows Archiv, January 25, 2011
985 Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells Cancer Science, January 25, 2011
986 A meta-analysis of the relation of polymorphism at sites -1082 and -592 of the IL-10 gene promoter with susceptibility and clearance to persistent hepatitis B virus infection in the Chinese population Infection, January 25, 2011 Evidence Based Medicine
987 Annexin A2 as a differential diagnostic marker of hepatocellular tumors Pathology - Research and Practice, January 25, 2011
988 Association between polymorphisms in the XRCC1 and GST genes, and CpG island methylation status in colonic mucosa in ulcerative colitis Virchows Archiv, January 25, 2011
989 Associations between gene polymorphisms of thymidylate synthase with its protein expression and chemosensitivity to 5-fluorouracil in pancreatic carcinoma cells Full Text Chinese Medical Journal, January 25, 2011
990 Systematic Review: Anti-Epidermal Growth Factor Receptor Treatment Effect Modification by KRAS Mutations in Advanced Colorectal Cancer Full Text Annals of Internal Medicine, January 24, 2011 Evidence Based Medicine
991 Complementarity-Determining Region 3 Size Spectratypes of T Cell Receptor beta Chains in CD8+ T Cells following Antiviral Treatment of Chronic Hepatitis B Antimicrobial Agents and Chemotherapy, January 24, 2011
992 p190RhoGEF (Rgnef) Promotes Colon Carcinoma Tumor Progression via Interaction with Focal Adhesion Kinase Full Text Cancer Research, January 24, 2011
993 PSPreg inhibits cultured pancreatic stellate cell and regulates MMP TIMP ratio European Journal of Clinical Investigation, January 24, 2011
994 Polymorphisms in Interleukin-1B (IL-1B) and Interleukin 1 Receptor Antagonist (IL-1RN) Genes Associate with Gastric Cancer Risk in the Chinese Population Digestive Diseases and Sciences, January 24, 2011
995 Reappraisal of the importance of mutations in the NS5A-PKR-binding domain of hepatitis C-1b virus in the era of optimally individualized therapy Journal of Viral Hepatitis, January 24, 2011
996 KRAS Mutation is Associated with Lung Metastasis in Patients with Curatively Resected Colorectal Cancer Full Text Clinical Cancer Research, January 24, 2011
997 Recruitment and Activation of a Lipid Kinase by Hepatitis C Virus NS5A Is Essential for Integrity of the Membranous Replication Compartment Cell Host & Microbe, January 21, 2011
998 Irinotecan and DNA-PKcs inhibitors synergize in killing of colon cancer cells Full Text Investigational New Drugs, January 21, 2011
999 Understanding How Hepatitis C Virus Builds Its Unctuous Home Cell Host & Microbe, January 21, 2011
1000 Identification of New Functional Regions in Hepatitis C Virus Envelope Glycoprotein E2 Journal of Virology, January 21, 2011
Clinical Pearls in Gastroenterology
- Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores: female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
- 33% of patients with suspected GERD are resistant or partially respond to PPIs
- Infliximab is the only TNF inhibitor approved by the FDA for ulcerative colitis.
Highlights in Gastroenterology
What is the best strategy for CRC screening?
As published in the NEJM, researchers in the COLONPREV study (Spain) have reported that fecal immunochemical testing (FIT) is as effective as colonoscopy in the detection of colorectal cancer (CRC). The study population was 50-69 years of age and comprised of 26,703 subjects who underwent a one-time colonoscopy and 26,599 subjects who underwent FIT every 2 years. The primary outcome measure was CRC deaths at 10 years. Participation in screening was greater in the FIT group than the colonoscopy group (34.2% vs. 24.6%). Detection of CRC was similar between the two groups (0.1%). Advanced and non-advanced adenomas were detected more frequently in the colonoscopy group than the FIT group (1.9% vs. 0.9% [OR=2.3] and 4.2% vs. 0.4% [OR=9.8], respectively).
Read the article summaryPPIs increase risk of Clostridium difficile infection
Based on a meta-analysis involving 30 observational studies and 202,965 patients, proton pump inhibitor therapy has been shown to significantly increase the risk of infection with Clostridium difficile (OR = 2.15).
Read the article summaryMetformin improves survival in patients with DM and CRC
In a single institution study involving 424 patients with DM and CRC, those patients treated with metformin had a 30% improvement in OS compared with patients not treated with metformin. Specifically, the metformin-treated patients had a mean survival of 76.9 months compared to 56.9 months.
Read the article summaryMost Popular Gastroenterology Articles
Last month's top read Top Articles of 20121 Tumor fibroblast–derived epiregulin promotes growth of colitis-associated neoplasms through ERK The Journal of Clinical Investigation, March 20, 2013 Free full text
2 Risk of Cancer in Cases of Suspected Lynch Syndrome Without Germline Mutation Gastroenterology, April 23, 2013 Review Article
3 Recurring and generalized visceroptosis in Ehlers-Danlos syndrome hypermobility type American Journal of Medical Genetics Part A, April 16, 2013 Review Article
4 Exploiting CTLA-4, PD-1 and PD-L1 to reactivate the host immune response against cancer British Journal of Cancer, March 22, 2013 Review Article
5 Diarrhoea is not the only symptom that needs to be treated in patients with microscopic colitis European Journal of Internal Medicine , April 9, 2013
6 Use and indications of cholestyramine and bile acid sequestrants Internal and Emergency Medicine, April 9, 2013 Review Article
7 A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population Obesity, March 26, 2013 Review Article
8 Hepatitis C virus impairs TLR3 signaling and inhibits IFN-{lambda} 1 expression in human hepatoma cell line Innate Immunity, April 3, 2013
9 Hepatic Dysfunction in Ambulatory Patients with Heart Failure - Application of the MELD Scoring System for Outcome Prediction JACC - Journal of the American College of Cardiology, April 26, 2013
10 MicroRNA-146a acts as a metastasis suppressor in gastric cancer by targeting WASF2 Cancer Letters, April 3, 2013 Review Article
11 Mitochondrial metabolism in the noncancerous liver determine the occurrence of hepatocellular carcinoma: a prospective study Journal of Gastroenterology, April 1, 2013 Review Article
12 Regulation of Eotaxin-3/CCL26 Expression by Th2 Cytokines in human Colonic Myofibroblasts Clinical and Experimental Immunology, April 25, 2013
13 Novel mutation in Progressive Familial Intrahepatic Cholestasis (PFIC) III Liver International, March 25, 2013
14 Regulation of cholesterol and bile acid homeostasis by the CYP7A1/SREBP2/miR-33a axis Hepatology, March 29, 2013 Review Article
15 IL-25 prevents and cures fulminant hepatitis through a myeloid-derived suppressor cell- dependent mechanism Hepatology, April 11, 2013 Review Article
16 Epigenomic plasticity enables human pancreatic {alpha} to {beta} cell reprogramming The Journal of Clinical Investigation, March 7, 2013 Free full text
17 Erythropoietin administration suppresses human monocyte function in vitro and during therapy-induced anemia in HCV patients Antiviral Research , April 17, 2013 Review Article
18 Contribution of Aurora-A and -B expression to DNA aneuploidy in gastric cancers Surgery Today, April 22, 2013 Review Article
19 Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins Clinical Cancer Research, April 16, 2013 Review Article
20 High resolution melting analysis of KRAS, BRAF and PIK3CA in KRAS exon 2 wild-type metastatic colorectal cancer BMC Cancer, April 2, 2013 Free full text Review Article
Indexed Journals in Gastroenterology: Gastroenterology, American Journal of Gastroenterology, Gut more
Other Topics in Gastroenterology
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