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Gastroenterology - Basic Science/Genetics News & Articles
Available now at MDLinx Gastroenterology: Ranked summaries of the most clinically-relevant GI literature refreshed every 24 hours, as well as MDLinx Gastroenterology exclusive content
- Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in your uniquely diverse field. In addition to general gastroenterology news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.
- MDLinx Gastroenterology exclusive content includes: Monthly highlights of the "can't miss" articles chosen by our physician editor, D. Scott Cunningham, MD, PhD; clinical pearls from The Smartest Internist and Smartest Family Physician daily competitions, a collaboration from the editors of MDLinx and Cleveland Clinic Center for Continuing Education; and pearls from our Pediatrics Physician Review quizzes.
Your Unread Messages in Gastroenterology
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Articles
Latest Full Text Articles (206)541 Upregulation of Hedgehog pathway is associated with cellular permissiveness for hepatitis C virus replication Hepatology, July 27, 2011
542 Knock-down of ubiquitin-specific protease 22 by micro-RNA interference inhibits colorectal cancer growth International Journal of Colorectal Disease, July 26, 2011
543 Phenotype-dependent production of des-γ-carboxy prothrombin in hepatocellular carcinoma Journal of Gastroenterology, July 26, 2011
544 An oestrogen receptor β-selective agonist exerts anti-neoplastic effects in experimental intrahepatic cholangiocarcinoma Digestive and Liver Diseases, July 25, 2011
545 Clinicopathological significance of cyclooxygenase-2 and cell cycle-regulatory proteins expression in patients with esophageal squamous cell carcinoma Diseases of the Esophagus, July 22, 2011
546 Immunomodulation of inducible co-stimulator (ICOS) in human cytokine-induced killer cells (CIKs) against cholangiocarcinoma through ICOS/ICOSL interaction Journal of Digestive Diseases, July 22, 2011
547 Vitamin D Status and Expression of Vitamin D Receptor and LL-37 in Patients with Spontaneous Bacterial Peritonitis Digestive Diseases and Sciences, July 18, 2011
548 Alternative targets within the endocannabinoid system for future treatment of gastrointestinal diseases Canadian Journal of Gastroenterology, July 15, 2011
549 TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres Gut, July 15, 2011
550 Pancreatic Cancer Cell Lines Can Induce Prostaglandin E2 Production from Human Blood Mononuclear Cells Journal of Oncology, July 13, 2011
551 miR-22 promotes HBV related hepatocellular carcinoma development in males Full Text Clinical Cancer Research, July 13, 2011
552 Endogenous histones function as alarmins in sterile inflammatory liver injury through toll-like receptor 9 Hepatology, July 13, 2011
553 The role of p38MAPK in the pathogenesis of inflammatory bowel disease Journal of Digestive Diseases, July 12, 2011
554 The interactions of age, genetics, and disease severity on tacrolimus dosing requirements after pediatric kidney and liver transplantation European Journal of Clinical Pharmacology, July 11, 2011
555 Ectopic expression of blood type antigens in inflamed mucosa with higher incidence of FUT2 secretor status in colonic Crohns disease Journal of Gastroenterology, July 7, 2011
556 Novel mutations of PRSS1 gene in patients with pancreatic cancer among Han population Full Text Chinese Medical Journal, July 7, 2011
557 TLR9 and the NLRP3 Inflammasome Link Acinar Cell Death With Inflammation in Acute Pancreatitis Gastroenterology, July 7, 2011
558 Aberrant DNA methylation associated with aggressiveness of gastrointestinal stromal tumour Gut, July 7, 2011
559 Novel feedback inhibition of surface antigen synthesis by mTOR signal and its implication for hepatitis B virus tumorigenesis and therapy Hepatology, July 7, 2011
560 Fine phenotypic and functional characterization of effector CD8+ T cells in patients with primary biliary cirrhosis Hepatology, July 7, 2011
Clinical Pearls in Gastroenterology
- Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores: female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
- 33% of patients with suspected GERD are resistant or partially respond to PPIs
- Infliximab is the only TNF inhibitor approved by the FDA for ulcerative colitis.
Highlights in Gastroenterology
What is the best strategy for CRC screening?
As published in the NEJM, researchers in the COLONPREV study (Spain) have reported that fecal immunochemical testing (FIT) is as effective as colonoscopy in the detection of colorectal cancer (CRC). The study population was 50-69 years of age and comprised of 26,703 subjects who underwent a one-time colonoscopy and 26,599 subjects who underwent FIT every 2 years. The primary outcome measure was CRC deaths at 10 years. Participation in screening was greater in the FIT group than the colonoscopy group (34.2% vs. 24.6%). Detection of CRC was similar between the two groups (0.1%). Advanced and non-advanced adenomas were detected more frequently in the colonoscopy group than the FIT group (1.9% vs. 0.9% [OR=2.3] and 4.2% vs. 0.4% [OR=9.8], respectively).
Read the article summaryPPIs increase risk of Clostridium difficile infection
Based on a meta-analysis involving 30 observational studies and 202,965 patients, proton pump inhibitor therapy has been shown to significantly increase the risk of infection with Clostridium difficile (OR = 2.15).
Read the article summaryMetformin improves survival in patients with DM and CRC
In a single institution study involving 424 patients with DM and CRC, those patients treated with metformin had a 30% improvement in OS compared with patients not treated with metformin. Specifically, the metformin-treated patients had a mean survival of 76.9 months compared to 56.9 months.
Read the article summaryMost Popular Gastro Articles
Last month's top read Top Articles of 20121 Diarrhoea is not the only symptom that needs to be treated in patients with microscopic colitis European Journal of Internal Medicine , April 9, 2013
2 Genetic susceptibility variants associated with colorectal cancer prognosis Carcinogenesis, May 29, 2013 Review Article
3 Antibodies against glycoprotein 2 are novel markers of intestinal inflammation in patients with an ileal pouch Journal of Crohn's and Colitis, May 15, 2013
4 Exploiting CTLA-4, PD-1 and PD-L1 to reactivate the host immune response against cancer British Journal of Cancer, March 22, 2013 Review Article
5 MTTP polymorphisms and susceptibility to non-alcoholic fatty liver disease in a Han Chinese population Liver International, May 16, 2013 Review Article
6 Mutations in the Ras–Raf Axis Underlie the Prognostic Value of CD133 in Colorectal Cancer Clinical Cancer Research, May 14, 2012 Free full text
7 The Phenotypic Expression of Inflammatory Bowel Disease in Patients with Primary Sclerosing Cholangitis Differs in the Distribution of Colitis Digestive Diseases and Sciences, May 14, 2013 Review Article
8 IFN-γ selectively exerts pro-apoptotic effects on tumor-initiating label-retaining colon cancer cells Cancer Letters, May 29, 2013
9 Migration and tolerance : On the road to tolerance — Generation and migration of gut regulatory T cells European Journal of Immunology, May 23, 2013 Review Article
10 Tumor fibroblast–derived epiregulin promotes growth of colitis-associated neoplasms through ERK The Journal of Clinical Investigation, March 20, 2013 Free full text
11 Identification of Novel Variants in Colorectal Cancer Families by High-Throughput Exome Sequencing Cancer Epidemiology, Biomarkers & Prevention, May 7, 2013
12 Utility of contrast-enhanced harmonic EUS in the diagnosis of malignant gallbladder polyps Gastrointestinal Endoscopy, May 8, 2013
13 The relationship between TNF-α gene polymorphism and susceptibility and clearance of the persistent hepatitis B virus infection in a Chinese population: A meta-analysis Clinical Microbiology and Infection, May 10, 2013 Evidence Based Medicine
14 Clinicopathological significance of S100 protein expression in cholangiocarcinoma Journal of Gastroenterology and Hepatology, April 29, 2013 Review Article
15 Hepatic Dysfunction in Ambulatory Patients with Heart Failure - Application of the MELD Scoring System for Outcome Prediction JACC - Journal of the American College of Cardiology, April 26, 2013
16 Understanding pancreatic cancer genomes Journal of Hepato-Biliary-Pancreatic Sciences, May 23, 2013
17 HBV core promoter mutations promote cellular proliferation through E2F1-mediated upregulation of S-phase kinase-associated protein 2 transcription Journal of Hepatology, May 20, 2013 Review Article
18 Triptolide Induces the Expression of miR-142-3p: a Negative Regulator of Heat Shock Protein 70 and Pancreatic Cancer Cell Proliferation Molecular Cancer Therapeutics, May 3, 2013 Review Article
19 ERK mitogen-activated protein kinase differentially regulates Th17- and Treg-cell development and contributes to the pathogenesis of colitis European Journal of Immunology, May 1, 2013
Indexed Journals in Gastroenterology: Gastroenterology, American Journal of Gastroenterology, Gut more
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