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Gastroenterology - Basic Science/Genetics News & Articles
Available now at MDLinx Gastroenterology: Ranked summaries of the most clinically-relevant GI literature refreshed every 24 hours, as well as MDLinx Gastroenterology exclusive content
- Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in your uniquely diverse field. In addition to general gastroenterology news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.
- MDLinx Gastroenterology exclusive content includes: Monthly highlights of the "can't miss" articles chosen by our physician editor, D. Scott Cunningham, MD, PhD; clinical pearls from The Smartest Internist and Smartest Family Physician daily competitions, a collaboration from the editors of MDLinx and Cleveland Clinic Center for Continuing Education; and pearls from our Pediatrics Physician Review quizzes.
Your Unread Messages in Gastroenterology
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Articles
Latest (1) Full Text Articles (206)441 Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac disease Gut, September 6, 2011
442 Prognostic Significance of NBS1 and Snail Expression in Esophageal Squamous Cell Carcinoma Annals of Surgical Oncology, September 6, 2011
443 Oestrogen receptor- CA repeat polymorphism is associated with incidence of colorectal cancer among females Histopathology, September 6, 2011
444 Mesothelin confers pancreatic cancer cell resistance to TNF-alpha-induced apoptosis through Akt/PI3K/NF-kappaB activation and IL-6/Mcl-1 overexpression Molecular Cancer, September 1, 2011
445 Matrix metalloproteinase 2 genotype is associated with nonanastomotic biliary strictures after orthotopic liver transplantation Liver International, September 1, 2011
446 Plumbagin Inhibits Invasion and Migration of Breast and Gastric Cancer Cells by Downregulating the Expression of Chemokine Receptor CXCR4 Molecular Cancer, September 1, 2011
447 Differential Activation of MAPK and PI3K/AKT/mTOR Pathways and IGF1R Expressionin Gastrointestinal Stromal Tumors Anticancer Research, August 31, 2011
448 Gene Polymorphisms MTHFRC677T and MTRA2756G as Predictive Factors in Adjuvant Chemotherapy for Stage III Colorectal Cancer Anticancer Research, August 31, 2011
449 Molecular Pathogenesis of Hepatocellular Carcinoma: Altering Transforming Growth Factor-β Signaling in Hepatocarcinogenesis Digestive Diseases, August 30, 2011
450 Characterization of naturally occurring protease inhibitor-resistance mutations in genotype 1b hepatitis C virus patients Hepatology International, August 30, 2011
451 Altered Endoplasmic Reticulum Stress Affects Translation in Inactive Colon Tissue From Patients With Ulcerative Colitis Gastroenterology, August 29, 2011
452 Hypoxia-inducible miR-210 augments the metastatic potential of tumor cells by targeting VMP1 in hepatocellular carcinoma Hepatology, August 25, 2011
453 Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors BMC Cancer, August 25, 2011
454 SOX9 is expressed in normal stomach, intestinal metaplasia, and gastric carcinoma in humans Journal of Gastroenterology, August 25, 2011
455 Upregulation of B7-H1 expression is associated with macrophage infiltration in hepatocellular carcinomas Cancer Immunology, Immunotherapy, August 24, 2011
456 Tissue expression of Toll-like receptors 2 and 4 in sporadic human colorectal cancer Cancer Immunology, Immunotherapy, August 24, 2011
457 Peroxisome proliferator-activated receptor δconfers resistance to peroxisome proliferator-activated receptor γ-induced apoptosis in colorectal cancer cells Oncogene, August 24, 2011
458 High expression of Galectin-1 in pancreatic stellate cells plays a role in the development and maintenance of an immunosuppressive microenvironment in pancreatic cancer International Journal of Cancer, August 24, 2011
459 Effects of mutation number in interferon sensitivity determining region on peripheral blood CD4+ T cell subsets (Th1, Th2) in chronic hepatitis C patients with hepatitis C virus genotype 1b and high viral load Hepatology International, August 24, 2011
460 Effects of E2F1-cyclin E1-E2 circuit down regulation in hepatocellular carcinoma cells Digestive and Liver Diseases, August 23, 2011
Clinical Pearls in Gastroenterology
- Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores: female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
- 33% of patients with suspected GERD are resistant or partially respond to PPIs
- Infliximab is the only TNF inhibitor approved by the FDA for ulcerative colitis.
Highlights in Gastroenterology
What is the best strategy for CRC screening?
As published in the NEJM, researchers in the COLONPREV study (Spain) have reported that fecal immunochemical testing (FIT) is as effective as colonoscopy in the detection of colorectal cancer (CRC). The study population was 50-69 years of age and comprised of 26,703 subjects who underwent a one-time colonoscopy and 26,599 subjects who underwent FIT every 2 years. The primary outcome measure was CRC deaths at 10 years. Participation in screening was greater in the FIT group than the colonoscopy group (34.2% vs. 24.6%). Detection of CRC was similar between the two groups (0.1%). Advanced and non-advanced adenomas were detected more frequently in the colonoscopy group than the FIT group (1.9% vs. 0.9% [OR=2.3] and 4.2% vs. 0.4% [OR=9.8], respectively).
Read the article summaryPPIs increase risk of Clostridium difficile infection
Based on a meta-analysis involving 30 observational studies and 202,965 patients, proton pump inhibitor therapy has been shown to significantly increase the risk of infection with Clostridium difficile (OR = 2.15).
Read the article summaryMetformin improves survival in patients with DM and CRC
In a single institution study involving 424 patients with DM and CRC, those patients treated with metformin had a 30% improvement in OS compared with patients not treated with metformin. Specifically, the metformin-treated patients had a mean survival of 76.9 months compared to 56.9 months.
Read the article summaryMost Popular Gastroenterology Articles
Last month's top read Top Articles of 20121 Tumor fibroblast–derived epiregulin promotes growth of colitis-associated neoplasms through ERK The Journal of Clinical Investigation, March 20, 2013 Free full text
2 Risk of Cancer in Cases of Suspected Lynch Syndrome Without Germline Mutation Gastroenterology, April 23, 2013 Review Article
3 Recurring and generalized visceroptosis in Ehlers-Danlos syndrome hypermobility type American Journal of Medical Genetics Part A, April 16, 2013 Review Article
4 Exploiting CTLA-4, PD-1 and PD-L1 to reactivate the host immune response against cancer British Journal of Cancer, March 22, 2013 Review Article
5 Diarrhoea is not the only symptom that needs to be treated in patients with microscopic colitis European Journal of Internal Medicine , April 9, 2013
6 Use and indications of cholestyramine and bile acid sequestrants Internal and Emergency Medicine, April 9, 2013 Review Article
7 A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population Obesity, March 26, 2013 Review Article
8 Hepatitis C virus impairs TLR3 signaling and inhibits IFN-{lambda} 1 expression in human hepatoma cell line Innate Immunity, April 3, 2013
9 Hepatic Dysfunction in Ambulatory Patients with Heart Failure - Application of the MELD Scoring System for Outcome Prediction JACC - Journal of the American College of Cardiology, April 26, 2013
10 MicroRNA-146a acts as a metastasis suppressor in gastric cancer by targeting WASF2 Cancer Letters, April 3, 2013 Review Article
11 Mitochondrial metabolism in the noncancerous liver determine the occurrence of hepatocellular carcinoma: a prospective study Journal of Gastroenterology, April 1, 2013 Review Article
12 Regulation of Eotaxin-3/CCL26 Expression by Th2 Cytokines in human Colonic Myofibroblasts Clinical and Experimental Immunology, April 25, 2013
13 Novel mutation in Progressive Familial Intrahepatic Cholestasis (PFIC) III Liver International, March 25, 2013
14 Regulation of cholesterol and bile acid homeostasis by the CYP7A1/SREBP2/miR-33a axis Hepatology, March 29, 2013 Review Article
15 IL-25 prevents and cures fulminant hepatitis through a myeloid-derived suppressor cell- dependent mechanism Hepatology, April 11, 2013 Review Article
16 Epigenomic plasticity enables human pancreatic {alpha} to {beta} cell reprogramming The Journal of Clinical Investigation, March 7, 2013 Free full text
17 Erythropoietin administration suppresses human monocyte function in vitro and during therapy-induced anemia in HCV patients Antiviral Research , April 17, 2013 Review Article
18 Contribution of Aurora-A and -B expression to DNA aneuploidy in gastric cancers Surgery Today, April 22, 2013 Review Article
19 Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins Clinical Cancer Research, April 16, 2013 Review Article
20 High resolution melting analysis of KRAS, BRAF and PIK3CA in KRAS exon 2 wild-type metastatic colorectal cancer BMC Cancer, April 2, 2013 Free full text Review Article
Indexed Journals in Gastroenterology: Gastroenterology, American Journal of Gastroenterology, Gut more
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