1A meta-analysis of the utility of C-reactive protein, erythrocyte sedimentation rate, fecal calprotectin, and fecal lactoferrin to exclude inflammatory bowel disease in adults with IBSThe American Journal of Gastroenterology  Clinical Article  Evidence Based Medicine
2Irritable bowel syndrome: a clinical reviewJAMA  Clinical Article  Evidence Based Medicine
3Differentiation of functional constipation and constipation predominant irritable bowel syndrome based on Rome III criteria: a population-based studyAlimentary Pharmacology and Therapeutics  Clinical Article
4Tenofovir rescue therapy in pregnant females with chronic hepatitis BWorld Journal of Gastroenterology  Full Text  Clinical Article
5The efficacy of a second anti-TNF in patients with inflammatory bowel disease whose previous anti-TNF treatment has failedAlimentary Pharmacology and Therapeutics  Evidence Based Medicine  Review Article
6Natural history of bleeding risk in colonic diverticulosis patients: a long-term colonoscopy-based cohort studyAlimentary Pharmacology and Therapeutics  Clinical Article
7Risk factors for acquisition of multidrug-resistant bacteria in patients with anastomotic leakage after colorectal cancer surgeryInternational Journal of Colorectal Disease  Clinical Article
8Impact of retroflexion vs. second forward view examination of the right colon on adenoma detection: a comparison studyThe American Journal of Gastroenterology  Clinical Article
9Hepatitis B virus reactivation and hepatitis in gastrointestinal cancer patients after chemotherapyCancer Chemotherapy and Pharmacology  Clinical Article
10Medical treatment versus surgery for treatment of gastroesophageal reflux diseaseTechniques in Gastrointestinal Endoscopy  Clinical Article
1Understanding how the stomach responds to injury could help target therapy against gastric damageAmerican Gastroenterological Association News
2Whole genome sequencing of pancreatic ductal adenocarcinomasEuropean Society for Medical Oncology News
3Mapping the gut microbiome to better understand its role in obesityGladstone Institutes News
4Gut bacteria may decrease weight loss from bariatric surgery: New study by Cedars-Sinai investigator presented at ENDO 2015 this weekCedars-Sinai
5Gut bacteria may decrease weight loss from bariatric surgeryCedars-Sinai
6Liquid biopsy to improve colorectal cancer careAgency for Science, Technology and Research (A*STAR) News
7Gut bacteria may contribute to diabetes in black malesUniversity of Illinois at Chicago Health News
8Media statement regarding CRE and duodenoscopeCedars-Sinai
9Prescription drug-induced liver failure is uncommon; over-the-counter medications and dietary/herbal supplements are most common causes, Penn study findsPenn Medicine
10Transmission of hepatitis C virus associated with surgical procedures - New Jersey 2010 and Wisconsin 2011Morbidity and Mortality Weekly Report

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Predictors of sustained binge drinking

As reported in Alcoholism: Clinical & Experimental Research, sustained binge drinkers have an earlier onset, drink monthly in secondary school, binged in their 20s, exhibit impulsivity and novelty-seeking, and have depressive symptoms during adolescence compared to those who stop binge drinking.

Increased MMP-9 expression associated with poor prognosis in CRC

As reported in the World Journal of Surgical Oncology, the expression of MMP-9 in colon cancer tissues was increased compared to distal normal mucosa (69.1% vs. 2.9%). Increased MMP-9 expression was associated with lymph node metastasis, Duke stage, and decreased survival.

SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

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Clinical Pearls

Clinical Pearl from Smartest DocGastroesophageal reflux disease is determined by an abnormal upper endoscopy or 24-hour pH-impedance monitoring.

Clinical Pearl from Smartest DocFish oil-enriched lipid emulsions reduce post-surgical infections.

Clinical Pearl from Smartest DocSonographie ggf. plus MRT ist in der Diagnostik von Appendizitis einfach durchführbar und vergleichbar mit CT.

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List