The Latest Journal Articles in Gastroenterology

1Diabetes and the risk of infections with immunomodulator therapy in inflammatory bowel diseasesAlimentary Pharmacology and Therapeutics, April 21, 2015  Clinical Article
2Nilotinib versus imatinib as first-line therapy for patients with unresectable or metastatic gastrointestinal stromal tumours (ENESTg1): a randomised phase 3 trialThe Lancet Oncology, April 21, 2015
3Proton pump inhibitor use significantly increases the risk of cryptogenic liver abscess: A population-based studyAlimentary Pharmacology and Therapeutics, April 21, 2015  Clinical Article
4Increase in nonhepatic diagnoses among persons with hepatitis C hospitalized for any cause, United States, 2004–2011Journal of Viral Hepatitis, April 21, 2015  Clinical Article
5Systematic review with meta-analysis: Post-infectious irritable bowel syndrome after travellers' diarrhoeaAlimentary Pharmacology and Therapeutics, April 21, 2015  Evidence Based Medicine  Review Article
6Probiotics in Helicobacter pylori eradication therapy: A systematic review and meta-analysisWorld Journal of Gastroenterology, April 21, 2015  Full Text  Evidence Based Medicine  Review Article
7Efficacy of S-1 vs capecitabine for the treatment of gastric cancer: A meta-analysisWorld Journal of Gastroenterology, April 21, 2015  Full Text  Evidence Based Medicine
8Treatment outcomes for eosinophilic esophagitis in children with esophageal atresiaDiseases of the Esophagus, April 21, 2015  Review Article
9Vedolizumab for the treatment of moderately to severely active ulcerative colitisPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, April 21, 2015  Review Article
10A matched cross-sectional study of the association between circulating tissue factor activity, immune activation and advanced liver fibrosis in hepatitis C infectionBMC Infectious Diseases, April 21, 2015  Full Text  Clinical Article
1Long non-coding RNA modulates colorectal cancer metabolismThe University of Texas MD Anderson Cancer Center, April 21, 2015
2Dual-energy CT imaging improves pancreatic cancer assessmentAmerican Roentgen Ray Society News, April 21, 2015
3To fight nasty digestive bugs, U-M scientists set out to build a better gut - using stem cellsUniversity of Michigan Health System, April 20, 2015
4Unprecedented microbial diversity reported in remote Amazonian tribeNYU Langone Medical Center, April 20, 2015
5New treatment for common digestive condition Barrett's OesophagusUniversity of Warwick Health and Medicine News, April 17, 2015
6New research sheds light on how popular probiotic benefits the gutUniversity of Maryland School of Medicine News, April 17, 2015
7NIH study finds genetic link for rare intestinal cancerNIH News, April 17, 2015
8Proton pump inhibitors are associated with an increased risk of acute kidney failure and acute interstitial nephritis in older patientsSt. Michael's Hospital, April 17, 2015
9CNIO links telomeres to the origins of liver diseases such as chronic hepatitis and cirrhosisCentro Nacional de Investigaciones Oncologicas News, April 17, 2015
10Exercise key to fighting fat in the liver and gutThe University of Sydney News, April 16, 2015

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Decreased PTPN12 expression associated with poor prognosis in HCC

As reported in PLoS ONE, the expression of PTPN12 was decreased in hepatocellular carcinoma tissue samples compared with adjacent normal tissues. Furthermore, decreased PTPN12 expression was associated with tumor recurrence, decreased cancer-specific survival, and decreased recurrence-free survival.

KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

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