1Booster influenza vaccination does not improve immune response in adult inflammatory bowel disease patients treated with immunosuppressives: A randomized controlled trialJournal of Gastroenterology  Clinical Article
2Safety and activity of alisertib, an investigational aurora kinase A inhibitor, in patients with breast cancer, small-cell lung cancer, non-small-cell lung cancer, head and neck squamous-cell carcinoma, and gastro-oesophageal adenocarcinoma: A five-arm phase 2 studyThe Lancet Oncology  Clinical Article
3NEOSCOPE: A randomised phase II study of induction chemotherapy followed by either oxaliplatin/capecitabine or paclitaxel/carboplatin based chemoradiation as pre-operative regimen for resectable oesophageal adenocarcinomaBMC Cancer  Full Text  Clinical Article
4Safety and efficacy of endoscopic spray cryotherapy for Barrett's dysplasia: results of the National Cryospray RegistryDiseases of the Esophagus  Clinical Article
5The prevalence of gastro-esophageal reflux disease and esophageal dysmotility in Chinese patients with idiopathic pulmonary fibrosisBMC Gastroenterology  Full Text  Clinical Article
6Nerve growth factor neutralization suppresses β-cell proliferation through activin A and betacellulinPancreas  Clinical Article
7Phase II study of mFOLFOX3 as second-line treatment after gemcitabine failure in patients with unresectable/metastatic biliary tract cancerCancer Chemotherapy and Pharmacology  Clinical Article
8Effectiveness and safety of immunomodulators with anti-TNF therapy in Crohn's diseaseClinical Gastroenterology and Hepatology  Clinical Article
9Helicobacter pylori induces serine phosphorylation of EGFR via novel TAK1-p38 activation pathway in an HB–EGF-independent manner.Helicobacter  Clinical Article
10Gender differences in fecal immunochemical test performance for early detection of colorectal neoplasiaClinical Gastroenterology and Hepatology  Clinical Article
1IU researchers: Pancreatic cancer patients with particular gene signature may benefit from personalized treatmentIndiana University School of Medicine News
2Widely used food additive promotes colitis, obesity and metabolic syndrome, research showsGeorgia State University News
3How the landscape of the pancreatic cancer genome is coming into viewGarvan Institute of Medical Research News
4Bariatric surgery affects risk of pregnancy complicationsKarolinska Institutet
5Plant chemicals may prevent liver damage caused by fat accumulated during menopauseUniversity of Georgia Research News
6NewYork-Presbyterian Hospital/Weill Cornell Medical Center develops new procedure to alleviate common side effects for gastric bypass patientsNewYork-Presbyterian
7Yale researchers reverse type 2 diabetes and fatty liver disease in ratsYale School of Medicine News
8Gut microbes targeted for diagnosis, treatment of childhood undernutritionWashington University School of Medicine in St. Louis News
9Nearly half a million Americans suffered from Clostridium difficile infections in a single yearCDC
10Stellate cells in the liver control regeneration and fibrosisGerman Cancer Research Center News

Show Me:

Calcium reduces CRC risk

As reported in the International Journal of Cancer, there is an 8% reduction in CRC risk with each 300 mg/d increase in calcium intake based on 15 studies involving 12305 patients who took 250-1900 mg of calcium/day over a 3.3-16 year follow-up period. The beneficial effect extended beyond 1000 mg/d.

Predictors of sustained binge drinking

As reported in Alcoholism: Clinical & Experimental Research, sustained binge drinkers have an earlier onset, drink monthly in secondary school, binged in their 20s, exhibit impulsivity and novelty-seeking, and have depressive symptoms during adolescence compared to those who stop binge drinking.

Elevated ?-GT predicts HCC in hepatitis C patients with sustained response

As reported in the Journal of Hepatology, an elevated baseline ɣ-GT level is the strongest predictor of developing HCC in non-cirrhotic patients with hepatitis C and a sustained virologic response (HR = 6.44), followed by age (HR = 3.68).

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Clinical Pearls

Clinical Pearl from Smartest DocBeta-cell function after total pancreatectomy and islet autotransplantation is dependent on islet yield.

Clinical Pearl from Smartest DocRecurrence of hepatitis C occurs in about 20% of HIV-infected patients.

Clinical Pearl from Smartest DocPrescribed position changes during colonoscope withdrawal do not affect polyp or adenoma detection compared with the usual practice.

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List