The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists. Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in Gastroenterology. In addition to general news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.
1 Systematic review with meta-analysis: magnetic resonance enterography signs for the detection of inflammation and intestinal damage in Crohn's disease Alimentary Pharmacology and Therapeutics, November 21, 2014 Clinical Article
2 High-dose dual therapy is superior to standard first-line or rescue therapy for Helicobacter pylori infection Clinical Gastroenterology and Hepatology , November 21, 2014 Clinical Article
3 Development of quality measures for the care of patients with gastroesophageal reflux disease Clinical Gastroenterology and Hepatology , November 21, 2014 Clinical Article
4 Multidisciplinary management of gastrointestinal fibrotic stenosis in Crohn's disease Digestive Diseases and Sciences, November 21, 2014 Clinical Article
5 Performance characteristics of the COBAS Ampliprep/COBAS TaqMan v2.0 and the Abbott RealTime hepatitis C assays – implications for response-guided therapy in genotype 1 infections Antiviral Therapy , November 21, 2014 Clinical Article
6 Lubiprostone vs Senna in postoperative orthopedic surgery patients with opioid-induced constipation: A double-blind, active-comparator trial Full Text World Journal of Gastroenterology, November 21, 2014 Clinical Article
7 Cerebral venous thrombosis in inflammatory bowel disease: A case series Journal of Digestive Diseases, November 21, 2014 Clinical Article
8 Overall efficacy and safety results of sofosbuvir-based therapies in Phase II and III studies Digestive and Liver Diseases, November 21, 2014 Clinical Article
9 Barrett’s esophagus: Diagnostic criteria, endoscopy and histology Best Practice & Research Clinical Gastroenterology , November 21, 2014 Review Article
10 Endogenous motilin, but not ghrelin plasma levels fluctuate in accordance with gastric phase III activity of the migrating motor complex in man Neurogastroenterology & Motility, November 21, 2014 Clinical Article
11 The low-FODMAP diet: An approach for controlling irritable bowel syndrome Topics in Clinical Nutrition, November 21, 2014 Clinical Article
12 The importance of fatigue cognitions in chronic hepatitis c infection Journal of Psychosomatic Research, November 21, 2014 Evidence Based Medicine
13 Clinical significance of circulating miR-122 in patients with dual chronic hepatitis B and C virus infection Hepatology International, November 21, 2014 Clinical Article
14 Newly designed, fully covered metal stents for endoscopic ultrasound (EUS)-guided transmural drainage of peripancreatic fluid collections: a prospective randomized study Endoscopy, November 21, 2014 Clinical Article
15 Beneficial effect of the 5-HT1A receptor agonist buspirone on esophageal dysfunction associated with systemic sclerosis: A pilot study United European Gastroenterology Journal, November 21, 2014 Clinical Article
16 Pancreaticobiliary maljunction and biliary cancer Journal of Gastroenterology, November 21, 2014 Clinical Article
17 New economic training model for installing ultrasound-guided drainages Zeitschrift für Gastroenterologie, November 21, 2014 Clinical Article
18 Prognostic prediction in gastric cancer patients without serosal invasion: Comparative study between UICC 7th edition and JCGS 13th edition N-classification systems Full Text Chinese Journal of Cancer Research, November 21, 2014 Clinical Article
19 Exaggerated smooth muscle contraction segments on esophageal high-resolution manometry: prevalence and clinical relevance Neurogastroenterology & Motility, November 21, 2014 Review Article
20 The cost of anal cancer in England: retrospective hospital data analysis and Markov model Full Text BMC Public Health, November 21, 2014 Clinical Article
As reported in the World Journal of Gastroenterology, the following risk factors for chronic hepatitis C (CHC)-related deaths have been identified (n=8250 CHC patients; n=144 CHC-related deaths): α-IFN therapy (AOR=0.53); liver cirrhosis (AOR=2.89); hepatocellular carcinoma versus CHC (AOR=8.82); hypertension (AOR=1.76); alcohol consumption (AOR=1.73); and HBsAg positivity (AOR=22.28).
As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.
Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.