Gastroenterology News Articles

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The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists. Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in Gastroenterology. In addition to general news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.

Ranked, sorted, and summarized by MDLinx editors from the latest literature
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1 Rilotumumab in combination with epirubicin, cisplatin, and capecitabine as first-line treatment for gastric or oesophagogastric junction adenocarcinoma: an open-label, dose de-escalation phase 1b study and a double-blind, randomised phase 2 study The Lancet Oncology, July 29, 2014    Clinical Article

2 A phase II, open-label, multicenter study to evaluate the antitumor efficacy of CO-1.01 as second-line therapy for gemcitabine-refractory patients with stage IV pancreatic adenocarcinoma and negative tumor hENT1 expression Pancreatology, July 29, 2014    Clinical Article

3 Adalimumab monotherapy versus combination therapy with immunomodulators in patients with Crohn's disease: A systematic review and meta-analysis Journal of Crohn's and Colitis, July 29, 2014    Evidence Based Medicine    Review Article

4 The clinical course of a gastrointestinal stromal tumor (GIST) diagnosed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) Digestive Endoscopy, July 29, 2014    Clinical Article

5 Clinical staging of patients with early esophageal adenocarcinoma: Does FDG-PET/CT have a role Journal of Thoracic Oncology, July 29, 2014    Clinical Article

6 Continuous versus intermittent chemotherapy strategies in metastatic colorectal cancer: a systematic review and meta-analysis Annals of Oncology, July 29, 2014    Evidence Based Medicine    Review Article

7 Optimal approach to the management of intrathoracic esophageal leak following esophagectomy: A systematic review. The American Journal of Surgery, July 29, 2014    Evidence Based Medicine    Review Article

8 Effects of antidepressants in patients with functional esophageal disorders or gastroesophageal reflux disease: a systematic review Clinical Gastroenterology and Hepatology , July 29, 2014    Evidence Based Medicine    Review Article

9 Critical items for assessing risk of lung and colorectal cancer in primary care: a Delphi study British Journal of General Practice, July 29, 2014    Evidence Based Medicine    Review Article

10 Clinical outcomes of hepatitis B virus co-infection in a United States cohort of hepatitis C virus-infected patients Hepatology, July 29, 2014    Clinical Article

11 Accuracy of magnetic resonance imaging in diagnosis of liver iron overload: a systematic review and meta-analysis Clinical Gastroenterology and Hepatology , July 29, 2014    Evidence Based Medicine    Review Article

12 Olmesartan, other antihypertensives, and chronic diarrhea among patients undergoing endoscopic procedures: a case-control study Mayo Clinic Proceedings, July 29, 2014    Evidence Based Medicine    Clinical Article

13 Fecal level of calprotectin identifies histologic inflammation in patients with ulcerative colitis in clinical and endoscopic remission Clinical Gastroenterology and Hepatology , July 29, 2014    Clinical Article

14 The association of metabolic syndrome and its factors with gallstone disease Full Text BMC Family Practice, July 29, 2014    Clinical Article

15 The impact of oxaliplatin-based chemotherapy for colorectal cancer on the autonomous nervous system European Journal of Neurology, July 29, 2014    Clinical Article

16 Comparative effectiveness research of chronic hepatitis B and C cohort study (CHES): improving data collection and cohort identification Digestive Diseases and Sciences, July 29, 2014    Clinical Article

17 Predictors of urgent findings on abdominopelvic CT in patients with Crohn’s disease presenting to the emergency department Digestive Diseases and Sciences, July 29, 2014    Clinical Article

18 Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: the COSMOS randomised study The Lancet, July 29, 2014    Evidence Based Medicine    Clinical Article

19 Induction therapy does not improve survival for clinical stage T2N0 esophageal cancer Journal of Thoracic Oncology, July 29, 2014    Clinical Article

20 Perfusion parameters of dynamic contrast-enhanced magnetic resonance imaging predict outcomes of hepatocellular carcinoma receiving radiotherapy with or without thalidomide Hepatology International, July 29, 2014    Clinical Article

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Highlights in Gastroenterology

SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

Infliximab is effective in corticosteroid-refractory ulcerative colitis

As reported in the Journal of Crohn’s & Colitis, treatment of corticosteroid-refractory ulcerative colitis patients with 3 doses of infliximab (n=113) resulted in short- (3 months) and long-term (12 months) colectomy rates of 18.6% and 25.6%, respectively. The RR of colectomy in patients with an elevated CRP and severe endoscopic lesions was 2.15 and 5.13, respectively.

Risk factors for CHC-related death identified

As reported in the World Journal of Gastroenterology, the following risk factors for chronic hepatitis C (CHC)-related deaths have been identified (n=8250 CHC patients; n=144 CHC-related deaths): α-IFN therapy (AOR=0.53); liver cirrhosis (AOR=2.89); hepatocellular carcinoma versus CHC (AOR=8.82); hypertension (AOR=1.76); alcohol consumption (AOR=1.73); and HBsAg positivity (AOR=22.28).


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