Gastroenterology News Articles

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The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists. Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in Gastroenterology. In addition to general news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.

Ranked, sorted, and summarized by MDLinx editors from the latest literature
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1 Predictors of mortality among patients undergoing colectomy for ischemic colitis: A population-based United States study Canadian Journal of Gastroenterology, December 19, 2014    Clinical Article

2 Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial The Lancet, December 19, 2014    Evidence Based Medicine    Clinical Article

3 The prevalence of NAFLD and NASH among patients with psoriasis in a tertiary care dermatology and rheumatology clinic Alimentary Pharmacology and Therapeutics, December 19, 2014    Clinical Article

4 Randomized phase II trial of gemcitabine plus TH-302 versus gemcitabine in patients with advanced pancreatic cancer Journal of Clinical Oncology, December 19, 2014    Clinical Article

5 Dietary intake in infants with complex congenital heart disease: A case-control study on macro- and micronutrient intake, meal frequency and growth Journal of Human Nutrition and Dietetics, December 19, 2014    Clinical Article

6 Support for patients with celiac disease: A literature review United European Gastroenterology Journal, December 19, 2014    Review Article

7 Hepatitis C virus RNA levels at week-2 of telaprevir/boceprevir administration are predictive of virological outcome Digestive and Liver Diseases, December 19, 2014    Clinical Article

8 Age at menarche and non-alcoholic fatty liver disease Journal of Hepatology, December 19, 2014    Clinical Article

9 Feasibility of a patient-centered deprescribing process to reduce inappropriate use of proton pump inhibitors Annals of Pharmacotherapy, December 19, 2014    Clinical Article

10 Concerns and worries in people living with inflammatory bowel disease (IBD): A mixed methods study Journal of Psychosomatic Research, December 19, 2014    Evidence Based Medicine    Clinical Article

11 Evidence-based clinical practice guidelines for irritable bowel syndrome Journal of Gastroenterology, December 19, 2014    Evidence Based Medicine

12 Sorafenib use in elderly patients with hepatocellular carcinoma: caution about use of platelet aggregation inhibitors Cancer Chemotherapy and Pharmacology, December 19, 2014    Clinical Article

13 Multiple-band imaging provides better value than white-light endoscopy in detection of dysplasia in patients with Barrett's esophagus Clinical Gastroenterology and Hepatology , December 19, 2014    Clinical Article

14 Identifying effective techniques within psychological treatments for irritable bowel syndrome: A meta-analysis Journal of Psychosomatic Research, December 19, 2014    Evidence Based Medicine

15 Abdomino-thoracic mechanisms of functional abdominal distension and correction by biofeedback Gastroenterology, December 19, 2014    Clinical Article

16 Old and new adjuvants for hepatitis B vaccines Medical Microbiology and Immunology, December 19, 2014    Clinical Article

17 A Phase I study of cabazitaxel in patients with advanced gastric cancer who have failed prior chemotherapy (GASTANA) Cancer Chemotherapy and Pharmacology, December 19, 2014    Clinical Article

18 A multi-institution phase II study of gemcitabine/cisplatin/S-1 (GCS) combination chemotherapy for patients with advanced biliary tract cancer (KHBO 1002) Cancer Chemotherapy and Pharmacology, December 19, 2014    Clinical Article

19 Perioperative enteral immunonutrition modulates systemic and mucosal immunity and the inflammatory response in patients with periampullary cancer scheduled for pancreaticoduodenectomy: a randomized clinical trial Pancreas, December 19, 2014    Clinical Article

20 Serrated adenoma prevalence in inflammatory bowel disease surveillance colonoscopy, and characteristics revealed by chromoendoscopy and virtual chromoendoscopy Canadian Journal of Gastroenterology, December 19, 2014    Clinical Article

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Highlights in Gastroenterology

SCCA-IgM predicts survival in HCC patients

As reported in the Journal of Gastroenterology & Hepatology, SCCA-IgM levels are elevated in patients with hepatocellular carcinoma (HCC) compared to patients with cirrhosis and healthy controls. Not only does the SCCA-IgM level predict overall and progression-free survival in HCC patients, but the sensitivity of SCCA-IgM in patients with HCC was 2-fold greater than AFP. A decline in SCCA-IgM levels was shown to be associated with response to treatment.

SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

Calcium reduces CRC risk

As reported in the International Journal of Cancer, there is an 8% reduction in CRC risk with each 300 mg/d increase in calcium intake based on 15 studies involving 12305 patients who took 250-1900 mg of calcium/day over a 3.3-16 year follow-up period. The beneficial effect extended beyond 1000 mg/d.


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