Gastroenterology News Articles

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The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists. Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in Gastroenterology. In addition to general news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.

Ranked, sorted, and summarized by MDLinx editors from the latest literature
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1 Effect of adjuvant capecitabine or fluorouracil, with or without oxaliplatin, on survival outcomes in stage III colon cancer and the effect of oxaliplatin on post-relapse survival: A pooled analysis of individual patient data from four randomised controlled trials The Lancet Oncology, November 25, 2014    Clinical Article

2 Prognosis after first-time myocardial infarction in patients with inflammatory bowel disease according to disease activity Circulation: Cardiovascular Quality and Outcomes, November 25, 2014    Clinical Article

3 Different antibiotic susceptibility between antrum and corpus of the stomach, a possible reason for treatment failure of Helicobacter pylori infection Full Text World Journal of Gastroenterology, November 25, 2014    Clinical Article

4 Acute hepatitis C infection in HIV-negative men who have sex with men Journal of Viral Hepatitis, November 25, 2014    Clinical Article

5 Two-week treatment with proton pump inhibitor is sufficient for healing post endoscopic submucosal dissection ulcers Full Text World Journal of Gastroenterology, November 25, 2014    Clinical Article

6 Association between antiviral treatment and extrahepatic outcomes in patients with hepatitis C virus infection Gut, November 25, 2014    Clinical Article

7 Docetaxel plus oxaliplatin with or without fluorouracil or capecitabine in metastatic or locally recurrent gastric cancer: A randomized phase II study Annals of Oncology, November 25, 2014    Clinical Article

8 Long-term risk of colorectal cancer in individuals with serrated polyps Gut, November 25, 2014    Clinical Article

9 miR-34a-5p suppresses colorectal cancer metastasis and predicts recurrence in patients with stage II/III colorectal cancer Oncogene, November 25, 2014    Clinical Article

10 Feasibility and safety of sorafenib treatment in hepatocellular carcinoma patients with spontaneous rupture Full Text World Journal of Gastroenterology, November 25, 2014    Clinical Article

11 Initial surgical management of ulcerative colitis in the biologic era Diseases of the Colon and Rectum, November 25, 2014    Clinical Article

12 Clinical and economic impact of drug eluting beads in transarterial chemoembolization for hepatocellular carcinoma Journal of Clinical Pharmacy and Therapeutics, November 25, 2014    Clinical Article

13 A systematic review and meta-analysis of somatic and germline DNA sequence biomarkers of esophageal cancer survival, therapy response and stage Annals of Oncology, November 25, 2014    Evidence Based Medicine    Review Article

14 Endoscopic ultrasonography-guided endoscopic treatment of pancreatic pseudocysts and walled-off necrosis: New technical developments Full Text World Journal of Gastroenterology, November 25, 2014    Review Article

15 Management of malignant colon polyps: Current status and controversies Full Text World Journal of Gastroenterology, November 25, 2014    Review Article

16 Development of risk scoring system for stratifying population for hepatocellular-carcinoma screening Hepatology, November 25, 2014    Clinical Article

17 HBsAg genetic elements critical for immune escape correlate with HBV-reactivation upon immunosuppression Hepatology, November 25, 2014    Clinical Article

18 TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway Oncogene, November 25, 2014    Clinical Article

19 Ribavirin induced hemolysis: A novel mechanism of action against chronic hepatitis C virus infection Full Text World Journal of Gastroenterology, November 25, 2014    Clinical Article

20 Potent antiviral therapy improves survival in acute on chronic liver failure due to hepatitis B virus reactivation Full Text World Journal of Gastroenterology, November 25, 2014    Review Article

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Highlights in Gastroenterology

Elevated ?-GT predicts HCC in hepatitis C patients with sustained response

As reported in the Journal of Hepatology, an elevated baseline ɣ-GT level is the strongest predictor of developing HCC in non-cirrhotic patients with hepatitis C and a sustained virologic response (HR = 6.44), followed by age (HR = 3.68).

Calcium reduces CRC risk

As reported in the International Journal of Cancer, there is an 8% reduction in CRC risk with each 300 mg/d increase in calcium intake based on 15 studies involving 12305 patients who took 250-1900 mg of calcium/day over a 3.3-16 year follow-up period. The beneficial effect extended beyond 1000 mg/d.

SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.


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