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The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists

  • Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in your uniquely diverse field. In addition to general gastroenterology news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.
  • MDLinx Gastroenterology exclusive content includes: Monthly highlights of the "can't miss" articles chosen by our physician editor, D. Scott Cunningham, MD, PhD; clinical pearls from The Smartest Internist and Smartest Family Physician daily competitions, a collaboration from the editors of MDLinx and Cleveland Clinic Center for Continuing Education; and pearls from our Pediatrics Physician Review quizzes.

Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 Exclusive enteral nutrition ameliorates mesenteric adipose tissue alterations in patients with active Crohn's disease Clinical Nutrition, July 22, 2014    Clinical Article

2 Immunological aspects of antiviral therapy of chronic hepatitis B virus and hepatitis C virus infections Hepatology, July 22, 2014    Review Article

3 Second-line oxaliplatin, folinic acid, and fluorouracil versus folinic acid and fluorouracil alone for gemcitabine-refractory pancreatic cancer: outcomes from the CONKO-003 trial Journal of Clinical Oncology, July 22, 2014    Clinical Article

4 A randomized double-blind controlled trial: Impact of probiotics on diarrhea in patients treated with pelvic radiation Clinical Nutrition, July 22, 2014    Clinical Article

5 Cellular and plasma uptake of parenteral omega-3 rich lipid emulsion fatty acids in patients with advanced pancreatic cancer Clinical Nutrition, July 22, 2014    Clinical Article

6 Adherence to the Mediterranean diet is associated with the severity of non-alcoholic fatty liver disease Clinical Nutrition, July 22, 2014    Clinical Article

7 Dysplasia in ulcerative colitis as a predictor of unsuspected synchronous colorectal cancer Diseases of the Colon and Rectum, July 22, 2014    Clinical Article

8 The impact of Clostridium difficile on pediatric surgical practice: A systematic review Pediatric Surgery International, July 22, 2014    Review Article

9 Second-line chemotherapy in advanced biliary cancer: a systematic review Annals of Oncology, July 22, 2014    Evidence Based Medicine    Review Article

10 Diagnosis and management of acute complications in patients with colon cancer: bleeding, obstruction, and perforation Full Text Chinese Journal of Cancer Research, July 22, 2014    Clinical Article

11 The impact of methadone maintenance therapy on heptatis C incidence among illicit drug users Addiction, July 22, 2014    Clinical Article

12 The comparisons of hepatitis C virus RNA level between intraoperative blood salvage (Cell Saver) and systemic hepatitis C virus RNA kinetics during liver transplantation Transplantation Proceedings, July 22, 2014    Clinical Article

13 l-Theanine healed NSAID-induced gastric ulcer by modulating pro/antioxidant balance in gastric ulcer margin Journal of Natural Medicines, July 22, 2014    Clinical Article

14 Gene expression analysis of pretreatment biopsies predicts the pathological response of esophageal squamous cell carcinomas to neo-chemoradiotherapy Annals of Oncology, July 22, 2014    Clinical Article

15 High homocysteine is associated with increased risk of colorectal cancer independently of oxidative stress and antioxidant capacities Clinical Nutrition, July 22, 2014    Clinical Article

16 Concurrent analysis of human equilibrative nucleoside transporter 1 and ribonucleotide reductase subunit 1 expression increases predictive value for prognosis in cholangiocarcinoma patients treated with adjuvant gemcitabine-based chemotherapy British Journal of Cancer, July 22, 2014    Clinical Article

17 Risk prediction of hepatocellular carcinoma in patients with cirrhosis: The ADRESS-HCC risk model Cancer, July 22, 2014    Clinical Article

18 Intraperitoneal chemotherapy as adjuvant treatment to prevent peritoneal carcinomatosis of colorectal cancer origin: a systematic review British Journal of Cancer, July 22, 2014    Clinical Article

19 The impact of hyoscine-N-butylbromide on adenoma detection during colonoscopy: meta-analysis of randomized, controlled studies Gastrointestinal Endoscopy, July 22, 2014    Evidence Based Medicine

20 Methylation of suppressor of cytokine signalling 1 gene promoter is associated with acute-on-chronic hepatitis B liver failure Journal of Viral Hepatitis, July 22, 2014    Clinical Article

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Clinical Pearls in Gastroenterology

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Highlights in Gastroenterology

What is the best strategy for CRC screening?

As published in the NEJM, researchers in the COLONPREV study (Spain) have reported that fecal immunochemical testing (FIT) is as effective as colonoscopy in the detection of colorectal cancer (CRC). The study population was 50-69 years of age and comprised of 26,703 subjects who underwent a one-time colonoscopy and 26,599 subjects who underwent FIT every 2 years. The primary outcome measure was CRC deaths at 10 years. Participation in screening was greater in the FIT group than the colonoscopy group (34.2% vs. 24.6%). Detection of CRC was similar between the two groups (0.1%). Advanced and non-advanced adenomas were detected more frequently in the colonoscopy group than the FIT group (1.9% vs. 0.9% [OR=2.3] and 4.2% vs. 0.4% [OR=9.8], respectively).

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PPIs increase risk of Clostridium difficile infection

Based on a meta-analysis involving 30 observational studies and 202,965 patients, proton pump inhibitor therapy has been shown to significantly increase the risk of infection with Clostridium difficile (OR = 2.15).

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Metformin improves survival in patients with DM and CRC

In a single institution study involving 424 patients with DM and CRC, those patients treated with metformin had a 30% improvement in OS compared with patients not treated with metformin. Specifically, the metformin-treated patients had a mean survival of 76.9 months compared to 56.9 months.

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