1A nurse-led accelerated procedure for infliximab infusion is well tolerated and effective in patients with inflammatory bowel diseaseDigestive and Liver Diseases  Clinical Article
2Lactose-free milk for infants with acute gastroenteritis in a developing country: study protocol for a randomized controlled trialTrials  Full Text  Clinical Article  Evidence Based Medicine
3Association of marital status and colorectal cancer screening participation in the United StatesColorectal Disease  Clinical Article
4Whipple's disease (Tropheryma whipplei infection) and its unmasking by tumour necrosis factor inhibitorsAlimentary Pharmacology and Therapeutics  Clinical Article  Review Article
5Morphologic and histologic changes in gastric adenomas after Helicobacter pylori eradication: A long-term prospective analysisHelicobacter  Clinical Article
6Irritable bowel syndrome: an integrated explanatory model for clinical practiceNeurogastroenterology & Motility  Clinical Article
7Hepatitis delta virus testing, epidemiology and management: A multicentre cross-sectional study of patients in LondonJournal of Clinical Virology  Clinical Article
8Imaging gastric structuring of lipid emulsions and its effect on gastrointestinal function: a randomized trial in healthy subjectsAmerican Journal of Clinical Nutrition  Clinical Article
9Integrated care increases treatment and improves outcomes of patients with chronic HCV infection and psychiatric illness or substance abuseClinical Gastroenterology and Hepatology  Clinical Article
10Biliary Dyskinesia: A surgical disease rarely found outside the United StatesThe American Journal of Surgery  Clinical Article
1Stellate cells in the liver control regeneration and fibrosisGerman Cancer Research Center News
2Nearly half a million Americans suffered from Clostridium difficile infections in a single yearCDC
3Discovery of the genetic fingerprint of aggressive colon tumoursInstitute for Research in Biomedicine (IRB Barcelona) News
4A genetic analysis predicts the risk of metastasis in colon cancerInstitute for Research in Biomedicine (IRB Barcelona) News
5Worldwide treatment of hepatitis C could be within sight at the right costUniversity of Liverpool News
6Study by Saint Luke’s Hospital gastroenterologists shows patients with inflammatory bowel disease are significantly more likely to have common liver diseaseSaint Luke's Health System
7Endoscopic retrograde cholangiopancreatography (ERCP) duodenoscopes: FDA safety communication - design may impede effective cleaningFDA
8Stalking a wily foe: U-M scientists figure out how C. difficile bacteria wreak havoc in the gutUniversity of Michigan Health System
9UCLA statement on notification of patients regarding endoscopic proceduresUCLA Health System
10Obesity epidemic needs new approachHarvard Gazette - Health News

Show Me:

Increased MMP-9 expression associated with poor prognosis in CRC

As reported in the World Journal of Surgical Oncology, the expression of MMP-9 in colon cancer tissues was increased compared to distal normal mucosa (69.1% vs. 2.9%). Increased MMP-9 expression was associated with lymph node metastasis, Duke stage, and decreased survival.

KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

SCCA-IgM predicts survival in HCC patients

As reported in the Journal of Gastroenterology & Hepatology, SCCA-IgM levels are elevated in patients with hepatocellular carcinoma (HCC) compared to patients with cirrhosis and healthy controls. Not only does the SCCA-IgM level predict overall and progression-free survival in HCC patients, but the sensitivity of SCCA-IgM in patients with HCC was 2-fold greater than AFP. A decline in SCCA-IgM levels was shown to be associated with response to treatment.

Are YOU the Smartest Doc in America?

The Smartest Doc from MDLinx keeps you current with a competitive edge, pitting colleagues against one other for the title of The Smartest Doc in America.

Take the Challenge

Clinical Pearls

Clinical Pearl from Smartest DocKrankenhauseinweisungen aufgrund von HCV-Monoinfektionen nahmen zwischen 1996 und 2010 deutlich ab.

Clinical Pearl from Smartest DocLittle is known about long-term effects of obesity interventions in preschool-aged children.

Clinical Pearl from Smartest DocFatigue and pruritus at the onset of primary biliary cirrhosis appear to be associated with more aggressive disease.

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List