Gastroenterology News Articles

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The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists. Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in Gastroenterology. In addition to general news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.

Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 Placebo response rate in clinical trials of fistulizing Crohn’s disease: Systematic review and meta-analysis Clinical Gastroenterology and Hepatology , September 22, 2014    Evidence Based Medicine    Review Article

2 Decline in hepatitis E virus antibody prevalence in the United States from 1988-1994 to 2009-2010 The Journal of Infectious Diseases, September 22, 2014    Clinical Article

3 A prospective study of the effect of bowel movement frequency, constipation, and laxative use on colorectal cancer risk The American Journal of Gastroenterology, September 22, 2014    Clinical Article

4 Parameters on esophageal pH impedance monitoring that predict outcomes of patients with gastroesophageal reflux disease Clinical Gastroenterology and Hepatology , September 22, 2014    Clinical Article

5 Psychological stress increases risk for peptic ulcer, regardless of Helicobacter pylori infection or use of nonsteroidal anti-inflammatory drugs Clinical Gastroenterology and Hepatology , September 22, 2014    Clinical Article

6 Optimal preparation for surgery in Crohn's disease Alimentary Pharmacology and Therapeutics, September 22, 2014    Review Article

7 Hepatic decompensation in patients with HIV/hepatitis B virus (HBV)/hepatitis C virus (HCV) triple infection versus HIV/HCV coinfection and the effect of anti-HBV nucleos(t)ide therapy Clinical Infectious Diseases, September 22, 2014    Clinical Article

8 Clinical and histological determinants of mortality for patients with Barrett’s esophagus-related T1 esophageal adenocarcinoma Clinical Gastroenterology and Hepatology , September 22, 2014    Review Article

9 Irritable bowel syndrome and chronic fatigue 6 years after Giardia infection: A controlled prospective cohort study Clinical Infectious Diseases, September 22, 2014    Clinical Article

10 Health-related quality of life in pediatric patients with functional and organic gastrointestinal diseases The Journal of Pediatrics, September 22, 2014    Clinical Article

11 Strategies for discontinuation of proton pump inhibitors: A systematic review Family Practice, September 22, 2014    Evidence Based Medicine    Review Article

12 Liver stiffness and aspartate aminotransferase levels predict the risk for liver fibrosis progression in hepatitis C virus/HIV-coinfected patients HIV Medicine, September 22, 2014    Clinical Article

13 Interaction between PNPLA3 I148M variant and age at infection in determining fibrosis progression in chronic hepatitis C PLOS ONE, September 22, 2014    Clinical Article

14 No association between centers for medicare and medicaid services payments and volume of medicare beneficiaries or per-capita health care costs for each state Clinical Gastroenterology and Hepatology , September 22, 2014    Clinical Article

15 Neonatal hyperbilirubinemia and childhood allergic diseases: a systematic review Pediatric Allergy and Immunology, September 22, 2014    Clinical Article

16 Suboptimal knowledge of and surveillance for hepatocellular carcinoma by primary care providers Clinical Gastroenterology and Hepatology , September 22, 2014    Clinical Article

17 A tool to predict risk for gastric cancer in patients with peptic ulcer disease on the basis of a nationwide cohort Clinical Gastroenterology and Hepatology , September 22, 2014    Clinical Article

18 Lubiprostone increases spontaneous bowel movement frequency and quality of life in patients with chronic idiopathic constipation Clinical Gastroenterology and Hepatology , September 22, 2014    Clinical Article

19 Functional deficits and symptoms of long-term survivors of colorectal cancer treated by multimodality therapy differ by age at diagnosis Journal of Gastrointestinal Surgery, September 22, 2014    Clinical Article

20 Relaxivity-iron calibration in hepatic iron overload: predictions of a monte carlo model Magnetic Resonance in Medicine, September 22, 2014    Clinical Article

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Highlights in Gastroenterology

Decreased PTPN12 expression associated with poor prognosis in HCC

As reported in PLoS ONE, the expression of PTPN12 was decreased in hepatocellular carcinoma tissue samples compared with adjacent normal tissues. Furthermore, decreased PTPN12 expression was associated with tumor recurrence, decreased cancer-specific survival, and decreased recurrence-free survival.

Infliximab is effective in corticosteroid-refractory ulcerative colitis

As reported in the Journal of Crohn’s & Colitis, treatment of corticosteroid-refractory ulcerative colitis patients with 3 doses of infliximab (n=113) resulted in short- (3 months) and long-term (12 months) colectomy rates of 18.6% and 25.6%, respectively. The RR of colectomy in patients with an elevated CRP and severe endoscopic lesions was 2.15 and 5.13, respectively.

SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

Other Topics in Gastroenterology

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