The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists. Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in Gastroenterology. In addition to general news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.
1 Therapeutic strategy for Crohn's disease with a loss of response to infliximab: A single-center retrospective study Digestion, January 27, 2015 Clinical Article
2 A pharmacokinetic comparison of Anrukinzumab, an anti- IL-13 monoclonal antibody, among healthy volunteers, asthma and ulcerative colitis patients British Journal of Clinical Pharmacology, January 27, 2015 Clinical Article
3 Long-term treatment with tenofovir in Asian-American chronic hepatitis B patients is associated with abnormal renal phosphate handling Digestive Diseases and Sciences, January 27, 2015 Clinical Article
4 Potential for proteomic approaches in determining efficacy biomarkers following administration of fish oils rich in omega-3 fatty acids: application in pancreatic cancers Nutrition in Clinical Practice, January 27, 2015 Review Article
5 Helicobacter pylori eradication cannot reduce the risk of gastric cancer in patients with intestinal metaplasia and dysplasia: evidence from a meta-analysis Gastric Cancer, January 27, 2015 Clinical Article
6 A phase II trial of concurrent 3D-CRT/IMRT and oxaliplatin, 5-fluorouracil and leucovorin (FOLFOX) in gastric cancer patients with R0 gastrectomy and D2 lymph node dissection Gastric Cancer, January 27, 2015 Clinical Article
7 Achieving sustained virologic response in hepatitis C: a systematic review of the clinical, economic and quality of life benefits Full Text BMC Infectious Diseases, January 27, 2015 Review Article
8 Time trends of the impact of Helicobacter pylori infection and nonsteroidal anti-inflammatory drugs on peptic ulcer bleeding in Japanese patients Digestion, January 27, 2015 Clinical Article
9 Nomograms to predict survival and the risk for developing local or distant recurrence in patients with rectal cancer treated with optional short-term radiotherapy Annals of Oncology, January 27, 2015 Clinical Article
10 Management of low-dose aspirin and clopidogrel in clinical practice: a gastrointestinal perspective Journal of Gastroenterology, January 27, 2015 Clinical Article
11 Sequential therapy or standard triple therapy for Helicobacter pylori infection: An updated systematic review American Journal of Therapeutics, January 27, 2015 Evidence Based Medicine Review Article
12 Efficacy and adverse events of EMR and endoscopic submucosal dissection for the treatment of colon neoplasms: a meta-analysis of studies comparing EMR and endoscopic submucosal dissection Gastrointestinal Endoscopy, January 27, 2015 Clinical Article
13 Predicting inadequate bowel preparation for colonoscopy in participants receiving split-dose bowel preparation: development and validation of a prediction score Gastrointestinal Endoscopy, January 27, 2015 Clinical Article
14 Hartmann's procedure in rectal cancer: a population-based study of postoperative complications International Journal of Colorectal Disease, January 27, 2015 Clinical Article
15 Long-term outcome of low perianal fistulas treated by fistulotomy: a multicenter study International Journal of Colorectal Disease, January 27, 2015 Clinical Article
16 ASGE Technology Committee systematic review and meta-analysis assessing the ASGE PIVI thresholds for adopting real-time endoscopic assessment of the histology of diminutive colorectal polyps Gastrointestinal Endoscopy, January 27, 2015 Clinical Article
17 Comparison of volume perfusion computed tomography and contrast-enhanced ultrasound for assessment of therapeutic effect of transarterial chemoembolization in patients with hepatocellular carcinoma: a preliminary report Acta Radiologica, January 27, 2015 Clinical Article
18 One-step insertion of low-profile gastrostomy in pediatric patients vs pull percutaneous endoscopic gastrostomy retrospective analysis of outcomes Journal of Parenteral and Enteral Nutrition, January 27, 2015 Clinical Article
19 Targeting cellular squalene synthase, an enzyme essential for cholesterol biosynthesis, is a potential antiviral strategy against hepatitis C virus Journal of Virology, January 27, 2015 Clinical Article
20 The light at the end of the tunnel: a single-operator learning curve analysis for per oral endoscopic myotomy Gastrointestinal Endoscopy, January 27, 2015 Clinical Article
As reported in the International Journal of Cancer, there is an 8% reduction in CRC risk with each 300 mg/d increase in calcium intake based on 15 studies involving 12305 patients who took 250-1900 mg of calcium/day over a 3.3-16 year follow-up period. The beneficial effect extended beyond 1000 mg/d.
As reported in the Journal of Hepatology, an elevated baseline ɣ-GT level is the strongest predictor of developing HCC in non-cirrhotic patients with hepatitis C and a sustained virologic response (HR = 6.44), followed by age (HR = 3.68).
As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.
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