The Latest Journal Articles in Gastroenterology

1Concomitant use of immunomodulators affects the durability of infliximab therapy in children with Crohn's diseaseClinical Gastroenterology and Hepatology , April 24, 2015  Clinical Article
2The epidemiology of acute hepatitis B in the United States from population-based surveillance, 2006-2011Clinical Infectious Diseases, April 24, 2015  Clinical Article
3Peptic ulcer bleeding risk. The role of Helicobacter pylori infection in NSAID/low-dose aspirin usersThe American Journal of Gastroenterology, April 24, 2015  Clinical Article
4The association of smoking and acute pancreatitis: a systematic review and meta-analysisPancreas, April 24, 2015  Evidence Based Medicine  Review Article
5A phase IB study of safety and pharmacokinetics of ramucirumab in combination with paclitaxel in patients with advanced gastric adenocarcinomasThe Oncologist, April 24, 2015  Full Text  Clinical Article
6Herbal traditional Chinese medicine and its evidence base in gastrointestinal disordersWorld Journal of Gastroenterology, April 24, 2015  Full Text  Evidence Based Medicine
7Prednisolone or pentoxifylline for alcoholic hepatitisNew England Journal of Medicine, April 24, 2015  Clinical Article  Evidence Based Medicine
8Nafamostat mesilate for prevention of post-ERCP pancreatitis: A meta-analysis of prospective, randomized, controlled trialsPancreas, April 24, 2015  Clinical Article  Evidence Based Medicine
9Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancerComplementary Therapies in Medicine, April 24, 2015  Clinical Article
10Treatment efficacy of sacral nerve stimulation in slow transit constipation: a two-phase, double-blind randomized controlled crossover studyThe American Journal of Gastroenterology, April 24, 2015  Clinical Article
1Pancreatic cancer breakthrough: Scientists turn cancer cells into normal cellsSanford-Burnham Medical Research Institute News, April 24, 2015
2Delayed diagnosis of coeliac disease may put lives at risk: Is screening the solution?United European Gastroenterology News, April 24, 2015
3Protein identified that serves as a "brake" on inflammationSt. Jude Children's Research Hospital News, April 24, 2015
4Cirrhosis deaths drop 41 percent from 2002 to 2012UNC Health Care System, April 24, 2015
5Alcoholic hepatitis treatments fail to keep patients aliveImperial College London Health News, April 24, 2015
6Mouth, as well as gut, could hold key to liver disease flare-upsVirginia Commonwealth University News, April 24, 2015
7Toxic mushroom-based drug may help battle colorectal cancerThe University of Texas MD Anderson Cancer Center, April 24, 2015
8VU team explores new cholesterol processing pathwayVanderbilt University Medical Center Research News, April 24, 2015
9Cancer drug shows promise as cure for hepatitis BThe Walter and Eliza Hall Institute of Medical Research News, April 23, 2015
10Throwing light on how to conduct a personalised pancreas cancer clinical trialGarvan Institute of Medical Research News, April 23, 2015

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SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

Risk factors for intra-abdominal abscesses in Crohn’s disease

As reported in Digestion, uncontrolled CRP at week 14 of therapy with infliximab (OR=1.36) and early loss of response to infliximab (OR=5.36) are independent risk factors for intra-abdominal abscesses in patients with Crohn’s disease.

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Clinical Pearl from Smartest DocData suggest that worldwide clarithromycin-based triple therapy is no longer effective for H. pylori eradication.

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