The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists. Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in Gastroenterology. In addition to general news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.
1 Steroid exposure, acute coronary syndrome, and inflammatory bowel disease: insights into the inflammatory milieu American Journal of Medicine, November 26, 2014 Clinical Article
2 Ehealth: Low FODMAP diet vs Lactobacillus rhamnosus GG in irritable bowel syndrome Full Text World Journal of Gastroenterology, November 26, 2014 Clinical Article
3 Efficacy and safety of gum chewing in adjunct to high-dose senna for bowel cleansing before colonoscopy: A single-blind randomized controlled trial Full Text Saudi Journal of Gastroenterology, November 26, 2014 Clinical Article
4 Current practices of screening for incident hepatitis C virus (HCV) infection among HIV-infected, HCV-uninfected individuals in primary care Clinical Infectious Diseases, November 26, 2014 Clinical Article
5 Functional gastrointestinal disorders in eating disorder patients: Altered distribution and predictors using ROME III compared to ROME II criteria Full Text World Journal of Gastroenterology, November 26, 2014 Clinical Article
6 Virologic resistance analysis from a phase 2 study of MK-5172 combined with pegylated interferon/ribavirin in treatment-naive patients with hepatitis C virus genotype 1 infection Clinical Infectious Diseases, November 26, 2014 Clinical Article
7 Multimodal therapy in treatment of rectal cancer is associated with improved survival and reduced local recurrence - A retrospective analysis over two decades Full Text BMC Cancer, November 26, 2014 Clinical Article
8 Enteral nutrition in acute pancreatitis: A review of the current evidence Full Text World Journal of Gastroenterology, November 26, 2014 Review Article
9 Risk of catheter-associated deep venous thrombosis in inflammatory bowel disease Diseases of the Colon and Rectum, November 26, 2014 Review Article
10 Relative impact of earlier diagnosis and improved treatment on survival for colorectal cancer: A US database study among elderly patients Cancer Epidemiology, November 26, 2014 Clinical Article
11 New tools for optimizing fluid resuscitation in acute pancreatitis Full Text World Journal of Gastroenterology, November 26, 2014 Review Article
12 Comparison of the antiviral effects of different nucleos(t)ide analogues in Chinese patients with chronic hepatitis B Full Text Saudi Journal of Gastroenterology, November 26, 2014 Clinical Article
13 Early versus on-demand nasoenteric tube feeding in acute pancreatitis New England Journal of Medicine, November 26, 2014 Evidence Based Medicine Clinical Article
14 Impact of colorectal cancer diagnosis and treatment on health-related quality of life among older Americans: A population-based, case-control study Cancer, November 26, 2014 Clinical Article
15 Combination therapy of interferon and nucleotide/nucleoside analogues for chronic hepatitis B Journal of Viral Hepatitis, November 26, 2014 Review Article
16 Hepatitis C infection and lymphoproliferative disease: Accidental comorbidities? Full Text World Journal of Gastroenterology, November 26, 2014 Review Article
17 Clinical outcomes of chronic hepatitis C patients related to baseline liver fibrosis stage – a hospital based linkage study Internal Medicine Journal, November 26, 2014 Clinical Article
18 Water immersion colonoscopy facilitates straight passage of the colonoscope through the sigmoid colon without loop formation: Randomized Controlled Trial Digestive Endoscopy, November 26, 2014 Clinical Article
19 Colonic diverticulitis in chemotherapy patients: Should operative indications change? A retrospective cohort study International Journal of Surgery, November 26, 2014 Clinical Article
20 Results of nurse navigator follow-up after positive colorectal cancer screening test: a randomized trial Full Text Journal of the American Board of Family Medicine, November 26, 2014 Clinical Article
As reported in the Journal of Gastroenterology & Hepatology, SCCA-IgM levels are elevated in patients with hepatocellular carcinoma (HCC) compared to patients with cirrhosis and healthy controls. Not only does the SCCA-IgM level predict overall and progression-free survival in HCC patients, but the sensitivity of SCCA-IgM in patients with HCC was 2-fold greater than AFP. A decline in SCCA-IgM levels was shown to be associated with response to treatment.
As reported in the International Journal of Cancer, there is an 8% reduction in CRC risk with each 300 mg/d increase in calcium intake based on 15 studies involving 12305 patients who took 250-1900 mg of calcium/day over a 3.3-16 year follow-up period. The beneficial effect extended beyond 1000 mg/d.
Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.