1Long-term outcome of infliximab combined with surgery for perianal fistulizing Crohn's diseaseWorld Journal of Gastroenterology  Full Text  Clinical Article
2Is combination of tetracycline and amoxicillin suitable for Helicobacter pylori infection?World Journal of Gastroenterology  Full Text  Evidence Based Medicine  Review Article
3Hepatitis C virus-mediated Aurora B kinase inhibition modulates inflammatory pathway and viral infectivityJournal of Hepatology  Clinical Article
4Value of the Gastroesophageal Reflux Disease Questionnaire (GerdQ) in predicting the proton pump inhibitor response in coronary artery disease patients with gastroesophageal reflux-related chest painDiseases of the Esophagus  Clinical Article
5Zinc for acute diarrhea and amoxicillin for pneumonia, do they work?The Indian Journal of Pediatrics  Clinical Article
6Population pharmacokinetic analysis of certolizumab pegol in patients with Crohn's diseaseThe Journal of Clinical Pharmacology  Clinical Article
7Preventive pancreatic stents in the management of acute biliary pancreatitis (PREPAST trial): Pre-study protocol for a multicenter, prospective, randomized, intervetnional, controlled trialPancreatology  Clinical Article
8Is it time to abandon the 5-cm margin rule during resection of distal gastric adenocarcinoma? A multi-institution study of the U.S. Gastric Cancer CollaborativeAnnals of Surgical Oncology  Clinical Article
9Early enteral nutrition compared with parenteral nutrition for esophageal cancer patients after esophagectomy: a meta-analysisDiseases of the Esophagus  Clinical Article
10Cross-sectional study of U.S. interns perceptions of clinical nutrition educationJournal of Parenteral and Enteral Nutrition  Clinical Article
1Transmission of hepatitis C virus associated with surgical procedures - New Jersey 2010 and Wisconsin 2011Morbidity and Mortality Weekly Report
2Prescription drug-induced liver failure is uncommon; over-the-counter medications and dietary/herbal supplements are most common causes, Penn study findsPenn Medicine
3Digestive brilliance of breast milk unravelledMonash University News
4Reducing disparities in colon cancer through integrated careKaiser Permanente Health Research News
5Published outcomes announced from study on adolescent bariatric surgery safetyNationwide Children's Hospital
6Standardization and simplification is key to helping NICU babies feed and growNationwide Children's Hospital
7New study details burden of C. diff in U.S.University of Rochester Medical Center
8Daclatasvir for hepatitis C: Hint of added benefit in genotype 4German Institute for Quality and Efficiency in Health Care (IQWiG)
9In lab research, SLU team halts NASH liver damageSaint Louis University Health News
10Use of new systemic adjuvant therapy in gastrointestinal tumors (GITSs) increasing, leading to better survivalAmerican Cancer Society News

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Risk factors for CHC-related death identified

As reported in the World Journal of Gastroenterology, the following risk factors for chronic hepatitis C (CHC)-related deaths have been identified (n=8250 CHC patients; n=144 CHC-related deaths): α-IFN therapy (AOR=0.53); liver cirrhosis (AOR=2.89); hepatocellular carcinoma versus CHC (AOR=8.82); hypertension (AOR=1.76); alcohol consumption (AOR=1.73); and HBsAg positivity (AOR=22.28).

SCCA-IgM predicts survival in HCC patients

As reported in the Journal of Gastroenterology & Hepatology, SCCA-IgM levels are elevated in patients with hepatocellular carcinoma (HCC) compared to patients with cirrhosis and healthy controls. Not only does the SCCA-IgM level predict overall and progression-free survival in HCC patients, but the sensitivity of SCCA-IgM in patients with HCC was 2-fold greater than AFP. A decline in SCCA-IgM levels was shown to be associated with response to treatment.

SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

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Clinical Pearls

Clinical Pearl from Smartest DocAvoidance of preoperative radiotherapy may reduce the likelihood of anastomotic leakage in colon cancer.

Clinical Pearl from Smartest DocGene polymorphisms of miR-27a and miR-146a are not associated with gastric cancer.

Clinical Pearl from Smartest DocResistance to first-line antibiotics for H. pylori is high in Latin America.

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List