Gastroenterology News Articles

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The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists. Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in Gastroenterology. In addition to general news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.

Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 Small intestinal bacterial overgrowth in inactive Crohn’s disease: Influence of thiopurine and biological treatment Full Text World Journal of Gastroenterology, October 20, 2014    Clinical Article

2 Abituzumab combined with cetuximab plus irinotecan versus cetuximab plus irinotecan alone for patients with KRAS wild-type metastatic colorectal cancer: The randomised phase I/II POSEIDON trial Annals of Oncology, October 20, 2014    Clinical Article

3 Potential blood-based markers of celiac disease Full Text BMC Gastroenterology, October 20, 2014    Clinical Article

4 Extra-hepatic manifestations of autochthonous hepatitis E infection Alimentary Pharmacology and Therapeutics, October 20, 2014    Review Article

5 Evaluation of early response to hepatic arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma using the combination of RECIST and tumor markers Journal of Gastroenterology and Hepatology, October 20, 2014    Clinical Article

6 Development and validation of a practical score to predict pain after excisional hemorrhoidectomy International Journal of Colorectal Disease, October 20, 2014    Clinical Article

7 Visceral fat area is associated with a high risk for early postoperative recurrence in crohn's disease Colorectal Disease, October 20, 2014    Clinical Article

8 The CAIRO4 study: the role of surgery of the primary tumour with few or absent symptoms in patients with synchronous unresectable metastases of colorectal cancer - A randomized phase III study of the Dutch Colorectal Cancer Group (DCCG) Full Text BMC Cancer, October 20, 2014    Clinical Article

9 Paleolithic and mediterranean diet pattern scores and risk of incident, sporadic colorectal adenomas American Journal of Epidemiology, October 20, 2014    Clinical Article

10 A national survey on the initial management of upper gastrointestinal bleeding Journal of Clinical Gastroenterology, October 20, 2014    Clinical Article

11 Simeprevir (TMC435) with pegylated interferon/ribavirin in patients coinfected with HCV genotype 1 and HIV-1: A phase 3 study Clinical Infectious Diseases, October 20, 2014    Clinical Article

12 Factors affecting the fate of faecal diversion in patients with perianal Crohn's disease Colorectal Disease, October 20, 2014    Clinical Article

13 Epistaxis in end stage liver disease masquerading as severe upper gastrointestinal hemorrhage Full Text World Journal of Gastroenterology, October 20, 2014    Clinical Article

14 Arterial stiffness in patients with non-alcoholic fatty liver disease is related to fibrosis stage and epicardial adipose tissue thickness Atherosclerosis, October 20, 2014    Clinical Article

15 Quality of colonoscopy in an organised colorectal cancer screening programme with immunochemical faecal occult blood test: the EQuIPE study (Evaluating Quality Indicators of the Performance of Endoscopy) Gut, October 20, 2014    Clinical Article

16 Conventional fractionated helical tomotherapy for patients with small to medium hepatocellular carcinomas without portal vein tumor thrombosis Full Text OncoTargets and Therapy, October 20, 2014    Clinical Article

17 Tumor genotype is an independent prognostic factor in primary gastrointestinal stromal tumors of gastric origin: A European multicenter analysis based on ConticaGIST Clinical Cancer Research, October 20, 2014    Clinical Article

18 Coeliac disease autoimmunity and hip fracture risk: Findings from a prospective cohort study Journal of Bone and Mineral Research, October 20, 2014    Clinical Article

19 Bone marrow-derived mesenchymal stem cell therapy for decompensated liver cirrhosis: A meta-analysis Full Text World Journal of Gastroenterology, October 20, 2014    Evidence Based Medicine

20 The Model for End-stage Liver Disease score is potentially a useful predictor of hyperkalemia occurrence among hospitalized angiotensin receptor blocker users Journal of Clinical Pharmacy and Therapeutics, October 20, 2014    Clinical Article

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Highlights in Gastroenterology

Risk factors for CHC-related death identified

As reported in the World Journal of Gastroenterology, the following risk factors for chronic hepatitis C (CHC)-related deaths have been identified (n=8250 CHC patients; n=144 CHC-related deaths): α-IFN therapy (AOR=0.53); liver cirrhosis (AOR=2.89); hepatocellular carcinoma versus CHC (AOR=8.82); hypertension (AOR=1.76); alcohol consumption (AOR=1.73); and HBsAg positivity (AOR=22.28).

SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

SCCA-IgM predicts survival in HCC patients

As reported in the Journal of Gastroenterology & Hepatology, SCCA-IgM levels are elevated in patients with hepatocellular carcinoma (HCC) compared to patients with cirrhosis and healthy controls. Not only does the SCCA-IgM level predict overall and progression-free survival in HCC patients, but the sensitivity of SCCA-IgM in patients with HCC was 2-fold greater than AFP. A decline in SCCA-IgM levels was shown to be associated with response to treatment.

Other Topics in Gastroenterology

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