We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Impact of immunosuppressive therapy on hepatitis B vaccination in inflammatory bowel diseasesEuropean Journal of Gastroenterology & Hepatology, July 07, 2015  Clinical Article
2Clinical management of patients with parenteral nutrition–dependent short bowel syndrome during teduglutide therapyJournal of Parenteral and Enteral Nutrition, July 07, 2015  Clinical Article
3A phase II study of biweekly S-1 and paclitaxel (SPA) as first-line chemotherapy in patients with metastatic or advanced gastric cancerCancer Chemotherapy and Pharmacology, July 07, 2015  Clinical Article
4Prevalence of coeliac disease in idiopathic hypoparathyroidism and effect of gluten free diet on calcaemic controlClinical Endocrinology, July 07, 2015  Clinical Article
5Liver fibrosis by transient elastography and virologic outcomes after introduction of tenofovir in lamivudine-experienced adults with HIV and hepatitis B virus coinfection in GhanaClinical Infectious Diseases, July 07, 2015  Clinical Article
6Efficacy and safety of diosmectite in acute childhood diarrhoea: A meta-analysisArchives of Diseases in Childhood, July 07, 2015  Evidence Based Medicine
7Safety of gadoxetate disodium: results from six clinical phase IV studies in 8194 patientsActa Radiologica, July 07, 2015  Clinical Article
8Serum hyaluronic acid in chronic viral hepatitis B and C: A biomarker for assessing liver fibrosis in chronic hemodialysis patientsInternational Urology and Nephrology, July 07, 2015  Clinical Article
9Risk factors for 30-day readmission following colorectal surgery: A systematic reviewJournal of Surgical Research, July 07, 2015  Evidence Based Medicine  Review Article
10Somatostatin analogues improve health-related quality of life in polycystic liver disease: a pooled analysis of two randomised, placebo-controlled trialsAlimentary Pharmacology and Therapeutics, July 07, 2015  Clinical Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Colon cancer: Taking a step back to move forwardWeizmann Institute of Science News, July 07, 2015
2The importance of placebos to medical careBeth Israel Deaconess Medical Center, July 06, 2015
3Cause of acute liver failure in young children discoveredTechnische Universität München, July 06, 2015
4Singapore team's discovery of new genomic aberrations of gastric cancer could pave the way for precision medicineAgency for Science, Technology and Research (A*STAR) News, July 06, 2015
5Abdominal blood clots may indicate undiagnosed cancerAarhus University Health News, July 06, 2015
6World GI 2015: Studies confirm regorafenib benefit in pre-treated metastatic colorectal cancerEuropean Society for Medical Oncology News, July 06, 2015
7McMaster researchers test fecal transplantation to treat ulcerative colitisMcMaster University Faculty of Health Sciences News, July 06, 2015
8Discovery promises new treatments to thwart colon cancerSt. Jude Children's Research Hospital News, July 06, 2015
9World GI 2015: Second-line cetuximab active beyond progression in quadruple wild-type patients with metastatic colorectal cancerEuropean Society for Medical Oncology News, July 06, 2015
10Anxiety increases the risk of gastrointestinal infection and long-term complicationsFlanders Institute for Biotechnology (VIB) News, July 03, 2015

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KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

Risk factors for CHC-related death identified

As reported in the World Journal of Gastroenterology, the following risk factors for chronic hepatitis C (CHC)-related deaths have been identified (n=8250 CHC patients; n=144 CHC-related deaths): α-IFN therapy (AOR=0.53); liver cirrhosis (AOR=2.89); hepatocellular carcinoma versus CHC (AOR=8.82); hypertension (AOR=1.76); alcohol consumption (AOR=1.73); and HBsAg positivity (AOR=22.28).

Infliximab is effective in corticosteroid-refractory ulcerative colitis

As reported in the Journal of Crohn’s & Colitis, treatment of corticosteroid-refractory ulcerative colitis patients with 3 doses of infliximab (n=113) resulted in short- (3 months) and long-term (12 months) colectomy rates of 18.6% and 25.6%, respectively. The RR of colectomy in patients with an elevated CRP and severe endoscopic lesions was 2.15 and 5.13, respectively.

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Clinical Pearls

Clinical Pearl from Smartest DocIV rehydration does not prevent subsequent unscheduled ED visits in children with gastroenteritis and mild-to-moderate dehydration.

Clinical Pearl from Smartest DocLower alcohol intake and a plant-based diet may lower risk for obesity-related cancers.

Clinical Pearl from Smartest DocBiological DMARDs may be used safely in patients with rheumatoid arthritis without clinical manifestations of HBV reactivation.

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