1Long-term outcome of infliximab combined with surgery for perianal fistulizing Crohn's diseaseWorld Journal of Gastroenterology  Full Text  Clinical Article
2Is combination of tetracycline and amoxicillin suitable for Helicobacter pylori infection?World Journal of Gastroenterology  Full Text  Evidence Based Medicine  Review Article
3Hepatitis C virus-mediated Aurora B kinase inhibition modulates inflammatory pathway and viral infectivityJournal of Hepatology  Clinical Article
4Value of the Gastroesophageal Reflux Disease Questionnaire (GerdQ) in predicting the proton pump inhibitor response in coronary artery disease patients with gastroesophageal reflux-related chest painDiseases of the Esophagus  Clinical Article
5Zinc for acute diarrhea and amoxicillin for pneumonia, do they work?The Indian Journal of Pediatrics  Clinical Article
6Population pharmacokinetic analysis of certolizumab pegol in patients with Crohn's diseaseThe Journal of Clinical Pharmacology  Clinical Article
7Preventive pancreatic stents in the management of acute biliary pancreatitis (PREPAST trial): Pre-study protocol for a multicenter, prospective, randomized, intervetnional, controlled trialPancreatology  Clinical Article
8Is it time to abandon the 5-cm margin rule during resection of distal gastric adenocarcinoma? A multi-institution study of the U.S. Gastric Cancer CollaborativeAnnals of Surgical Oncology  Clinical Article
9Early enteral nutrition compared with parenteral nutrition for esophageal cancer patients after esophagectomy: a meta-analysisDiseases of the Esophagus  Clinical Article
10Cross-sectional study of U.S. interns perceptions of clinical nutrition educationJournal of Parenteral and Enteral Nutrition  Clinical Article
1Prescription drug-induced liver failure is uncommon; over-the-counter medications and dietary/herbal supplements are most common causes, Penn study findsPenn Medicine
2Digestive brilliance of breast milk unravelledMonash University News
3Transmission of hepatitis C virus associated with surgical procedures - New Jersey 2010 and Wisconsin 2011Morbidity and Mortality Weekly Report
4New study details burden of C. diff in U.S.University of Rochester Medical Center
5Published outcomes announced from study on adolescent bariatric surgery safetyNationwide Children's Hospital
6Reducing disparities in colon cancer through integrated careKaiser Permanente Health Research News
7Standardization and simplification is key to helping NICU babies feed and growNationwide Children's Hospital
8In lab research, SLU team halts NASH liver damageSaint Louis University Health News
9Daclatasvir for hepatitis C: Hint of added benefit in genotype 4German Institute for Quality and Efficiency in Health Care (IQWiG)
10Use of new systemic adjuvant therapy in gastrointestinal tumors (GITSs) increasing, leading to better survivalAmerican Cancer Society News

Show Me:

SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

Risk factors for intra-abdominal abscesses in Crohn’s disease

As reported in Digestion, uncontrolled CRP at week 14 of therapy with infliximab (OR=1.36) and early loss of response to infliximab (OR=5.36) are independent risk factors for intra-abdominal abscesses in patients with Crohn’s disease.

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Clinical Pearls

Clinical Pearl from Smartest DocSSRIs are associated with an almost 2-fold increase in the risk of upper GI bleeding.

Clinical Pearl from Smartest DocSäurereflux kann die Integrität der Ösophagusmukosa beeinträchtigen.

Clinical Pearl from Smartest DocUnterschiede der duodenalen Flora könnten für die unterschiedliche Expression duodenaler Mukosarezeptoren verantwortlich sein, die bei der Zöliakie beobachtet werden.

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List