Gastroenterology News Articles

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The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists. Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in Gastroenterology. In addition to general news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.

Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

1 Antiviral therapy improves post-hepatectomy survival in patients with hepatitis B virus-related hepatocellular carcinoma: A prospective-retrospective study Alimentary Pharmacology and Therapeutics, November 24, 2014    Clinical Article

2 Pharmacological intervention based on fecal calprotectin levels in patients with ulcerative colitis at high risk of a relapse: A prospective, randomized, controlled study United European Gastroenterology Journal, November 24, 2014    Clinical Article

3 Validation of the Lewis score for the evaluation of small-bowel Crohn's disease activity Endoscopy, November 24, 2014    Clinical Article

4 Dose-dependent effects of lesogaberan on reflux measures in patients with refractory gastroesophageal reflux disease: A randomized, placebo-controlled study Full Text BMC Gastroenterology, November 24, 2014    Clinical Article

5 Fish consumption and risk of non–gallstone-related acute pancreatitis: a prospective cohort study American Journal of Clinical Nutrition, November 24, 2014    Clinical Article

6 Intensive follow-up strategies improve outcomes in non-metastatic colorectal cancer patients after curative surgery. A systematic review and meta-analysis Annals of Oncology, November 24, 2014    Review Article

7 Combination therapy with sorafenib and radiofrequency ablation for BCLC Stage 0–B1 hepatocellular carcinoma: A multicenter retrospective cohort study The American Journal of Gastroenterology, November 24, 2014    Clinical Article

8 Measurement of gastric emptying in the critically ill Clinical Nutrition, November 24, 2014    Clinical Article

9 Oral anti-CD3 immunotherapy for HCV-nonresponders is safe, promotes regulatory T cells and decreases viral load and liver enzyme levels: Results of a phase-2a placebo-controlled trial Journal of Viral Hepatitis, November 24, 2014    Clinical Article

10 Altered duodenal microbiota composition in celiac disease patients suffering from persistent symptoms on a long-term gluten-free diet The American Journal of Gastroenterology, November 24, 2014    Clinical Article

11 Influence of hepatitis B virus reactivation on the recurrence of HBV-related hepatocellular carcinoma after curative resection in patients with low viral load Journal of Viral Hepatitis, November 24, 2014    Clinical Article

12 Recombinant hepatitis C virus envelope glycoprotein vaccine elicits antibodies targeting multiple epitopes on the envelope glycoproteins associated with broad cross-neutralization Journal of Virology, November 24, 2014    Clinical Article

13 Sorafenib inhibits macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion Journal of Hepatology, November 24, 2014    Clinical Article

14 Increased incidence of inflammatory bowel disease in Québec residents with airway diseases European Respiratory Journal , November 24, 2014    Clinical Article

15 A core outcome set for clinical trials in acute diarrhoea Archives of Diseases in Childhood, November 24, 2014    Clinical Article

16 Nonalcoholic fatty liver disease: A precursor of the metabolic syndrome Digestive and Liver Diseases, November 24, 2014    Clinical Article

17 Treatment of colorectal liver metastases in Germany: A ten-year population-based analysis of 5772 cases of primary colorectal adenocarcinoma Full Text BMC Cancer, November 24, 2014    Clinical Article

18 Childhood malnutrition and the intestinal microbiome Pediatric Research, November 24, 2014    Review Article

19 Association of variants in genes encoding for macrophage-related functions with clinical outcome in patients with loco-regional gastric cancer Annals of Oncology, November 24, 2014    Clinical Article

20 Involvement of adiponectin in early stage of colorectal carcinogenesis Full Text BMC Cancer, November 24, 2014    Clinical Article

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Highlights in Gastroenterology

Elevated ?-GT predicts HCC in hepatitis C patients with sustained response

As reported in the Journal of Hepatology, an elevated baseline ɣ-GT level is the strongest predictor of developing HCC in non-cirrhotic patients with hepatitis C and a sustained virologic response (HR = 6.44), followed by age (HR = 3.68).

KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

Infliximab is effective in corticosteroid-refractory ulcerative colitis

As reported in the Journal of Crohn’s & Colitis, treatment of corticosteroid-refractory ulcerative colitis patients with 3 doses of infliximab (n=113) resulted in short- (3 months) and long-term (12 months) colectomy rates of 18.6% and 25.6%, respectively. The RR of colectomy in patients with an elevated CRP and severe endoscopic lesions was 2.15 and 5.13, respectively.


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