The Latest Clinical Articles in Gastroenterology & GastroIntestinal

1Effect of immunosuppressive therapies for the treatment of inflammatory bowel disease on response to routine vaccinations: a meta-analysisDigestive Diseases and Sciences, March 31, 2015  Clinical Article
2Improved pharmacodynamics and pharmacokinetics after I.V. application of peginterferon alfa-2a in hepatitis C null-respondersLiver International, March 31, 2015  Clinical Article
3Inpatient burden of childhood functional GI disorders in the USA: an analysis of national trends in the USA from 1997 to 2009Neurogastroenterology & Motility, March 31, 2015  Clinical Article
4Hormonal and reproductive factors and risk of esophageal cancer in women: a meta-analysisDiseases of the Esophagus, March 31, 2015  Evidence Based Medicine
5Tenofovir disoproxil fumarate has a substantial efficacy against multidrug resistant strains of hepatitis B virusLiver International, March 31, 2015  Clinical Article
6Helicobacter pylori negative gastric cancer: characteristics and endoscopic findingsDigestive Endoscopy, March 31, 2015  Review Article
7Psychoactive medications increase the risk of falls and fall-related injuries in hospitalized patients with cirrhosisClinical Gastroenterology and Hepatology , March 31, 2015  Clinical Article
8Advantages of fecal lactoferrin measurement during granulocyte and monocyte adsorptive apheresis therapy in ulcerative colitisDigestion, March 31, 2015  Clinical Article
9Status of competency-based medical education in endoscopy training: A nationwide survey of US ACGME-Accredited Gastroenterology Training ProgramsThe American Journal of Gastroenterology, March 31, 2015  Clinical Article
10Breath methane excretion is not an accurate marker of colonic methane production in irritable bowel syndromeThe American Journal of Gastroenterology, March 31, 2015  Clinical Article
1Genetic background determines whether aspirin/NSAIDS will reduce colorectal cancer riskMassachusetts General Hospital, March 31, 2015
2Drinking raw milk dramatically increases risk for foodborne illness, analysis findsJohns Hopkins Bloomberg School of Public Health, March 31, 2015
3ASCP, CAP, AMP, and ASCO issue draft colorectal cancer molecular marker testing guideline and announce opening of public comment periodAmerican Society of Clinical Oncology (ASCO) News, March 31, 2015
4FDA warns against combination of hepatitis C treatment and antiarrhythmic drugAmerican College of Cardiology News, March 31, 2015
5MAIT cell alterations involved in obesity and T2 diabetesCentre National de la Recherche Scientifique News, March 31, 2015
6Researchers reverse type 2 diabetes and fatty liver diseaseUniversity of Copenhagen Faculty of Health and Medical Sciences News, March 30, 2015
7How our DNA may prevent bowel cancerUniversity of Melbourne News, March 30, 2015
8American College of Physicians joins HHS in accelerating alternative payment methods through ‘Health Care Payment Learning and Action Network’ American College of Physicians News, March 26, 2015
9Exciting data presented at the 4th Gut Microbiota For Health SummitAmerican Gastroenterological Association News, March 23, 2015
10NCCS pioneers new drug regimen which reduces toxicities for renal cancer patientsNational Cancer Centre Singapore News, March 23, 2015

Show Me:

Elevated ?-GT predicts HCC in hepatitis C patients with sustained response

As reported in the Journal of Hepatology, an elevated baseline ɣ-GT level is the strongest predictor of developing HCC in non-cirrhotic patients with hepatitis C and a sustained virologic response (HR = 6.44), followed by age (HR = 3.68).

SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

Infliximab is effective in corticosteroid-refractory ulcerative colitis

As reported in the Journal of Crohn’s & Colitis, treatment of corticosteroid-refractory ulcerative colitis patients with 3 doses of infliximab (n=113) resulted in short- (3 months) and long-term (12 months) colectomy rates of 18.6% and 25.6%, respectively. The RR of colectomy in patients with an elevated CRP and severe endoscopic lesions was 2.15 and 5.13, respectively.

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Clinical Pearl from Smartest DocTelbivudine seems to be more effective than entecavir in treatment-naïve HBeAg+ patients with chronic hepatitis B.

Clinical Pearl from Smartest Doc46% of all patients with acute lower GI bleeding experience rebleeding.

Clinical Pearl from Smartest DocA preoperative NLR of more than 3 is an independent prognostic factor for DFS in non-metastatic colorectal cancer.

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