The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists. Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in Gastroenterology. In addition to general news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.
1 Predictors of mortality among patients undergoing colectomy for ischemic colitis: A population-based United States study Canadian Journal of Gastroenterology, December 19, 2014 Clinical Article
2 Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial The Lancet, December 19, 2014 Evidence Based Medicine Clinical Article
3 The prevalence of NAFLD and NASH among patients with psoriasis in a tertiary care dermatology and rheumatology clinic Alimentary Pharmacology and Therapeutics, December 19, 2014 Clinical Article
4 Randomized phase II trial of gemcitabine plus TH-302 versus gemcitabine in patients with advanced pancreatic cancer Journal of Clinical Oncology, December 19, 2014 Clinical Article
5 Dietary intake in infants with complex congenital heart disease: A case-control study on macro- and micronutrient intake, meal frequency and growth Journal of Human Nutrition and Dietetics, December 19, 2014 Clinical Article
6 Support for patients with celiac disease: A literature review United European Gastroenterology Journal, December 19, 2014 Review Article
7 Hepatitis C virus RNA levels at week-2 of telaprevir/boceprevir administration are predictive of virological outcome Digestive and Liver Diseases, December 19, 2014 Clinical Article
8 Age at menarche and non-alcoholic fatty liver disease Journal of Hepatology, December 19, 2014 Clinical Article
9 Feasibility of a patient-centered deprescribing process to reduce inappropriate use of proton pump inhibitors Annals of Pharmacotherapy, December 19, 2014 Clinical Article
10 Concerns and worries in people living with inflammatory bowel disease (IBD): A mixed methods study Journal of Psychosomatic Research, December 19, 2014 Evidence Based Medicine Clinical Article
11 Evidence-based clinical practice guidelines for irritable bowel syndrome Journal of Gastroenterology, December 19, 2014 Evidence Based Medicine
12 Sorafenib use in elderly patients with hepatocellular carcinoma: caution about use of platelet aggregation inhibitors Cancer Chemotherapy and Pharmacology, December 19, 2014 Clinical Article
13 Multiple-band imaging provides better value than white-light endoscopy in detection of dysplasia in patients with Barrett's esophagus Clinical Gastroenterology and Hepatology , December 19, 2014 Clinical Article
14 Identifying effective techniques within psychological treatments for irritable bowel syndrome: A meta-analysis Journal of Psychosomatic Research, December 19, 2014 Evidence Based Medicine
15 Abdomino-thoracic mechanisms of functional abdominal distension and correction by biofeedback Gastroenterology, December 19, 2014 Clinical Article
16 Old and new adjuvants for hepatitis B vaccines Medical Microbiology and Immunology, December 19, 2014 Clinical Article
17 A Phase I study of cabazitaxel in patients with advanced gastric cancer who have failed prior chemotherapy (GASTANA) Cancer Chemotherapy and Pharmacology, December 19, 2014 Clinical Article
18 A multi-institution phase II study of gemcitabine/cisplatin/S-1 (GCS) combination chemotherapy for patients with advanced biliary tract cancer (KHBO 1002) Cancer Chemotherapy and Pharmacology, December 19, 2014 Clinical Article
19 Perioperative enteral immunonutrition modulates systemic and mucosal immunity and the inflammatory response in patients with periampullary cancer scheduled for pancreaticoduodenectomy: a randomized clinical trial Pancreas, December 19, 2014 Clinical Article
20 Serrated adenoma prevalence in inflammatory bowel disease surveillance colonoscopy, and characteristics revealed by chromoendoscopy and virtual chromoendoscopy Canadian Journal of Gastroenterology, December 19, 2014 Clinical Article
As reported in the Journal of Gastroenterology & Hepatology, SCCA-IgM levels are elevated in patients with hepatocellular carcinoma (HCC) compared to patients with cirrhosis and healthy controls. Not only does the SCCA-IgM level predict overall and progression-free survival in HCC patients, but the sensitivity of SCCA-IgM in patients with HCC was 2-fold greater than AFP. A decline in SCCA-IgM levels was shown to be associated with response to treatment.
As reported in PLoS ONE, the expression of PTPN12 was decreased in hepatocellular carcinoma tissue samples compared with adjacent normal tissues. Furthermore, decreased PTPN12 expression was associated with tumor recurrence, decreased cancer-specific survival, and decreased recurrence-free survival.
As reported in the International Journal of Cancer, there is an 8% reduction in CRC risk with each 300 mg/d increase in calcium intake based on 15 studies involving 12305 patients who took 250-1900 mg of calcium/day over a 3.3-16 year follow-up period. The beneficial effect extended beyond 1000 mg/d.