Gastroenterology News Articles

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The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists. Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in Gastroenterology. In addition to general news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.

Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 Once versus three times daily dosing of oral budesonide for active Crohn's disease: A double-blind, double-dummy, randomised trial Journal of Crohn's and Colitis, August 28, 2014    Clinical Article

2 Loss of hepatitis B surface antigen in a real-life clinical cohort of patients with chronic hepatitis B virus infection Liver International, August 28, 2014    Clinical Article

3 Inverse associations of total and decaffeinated coffee with liver enzyme levels in NHANES 1999-2010 Hepatology, August 28, 2014    Clinical Article

4 Quality of life and health care consultation in 13 to 18 year olds with abdominal pain predominant functional gastrointestinal diseases Full Text BMC Gastroenterology, August 28, 2014    Clinical Article

5 A VELOUR post hoc subset analysis: Prognostic groups and treatment outcomes in patients with metastatic colorectal cancer treated with aflibercept and FOLFIRI Full Text BMC Cancer, August 28, 2014    Clinical Article

6 Carboplatin and paclitaxel as first-line treatment of unresectable or metastatic esophageal or gastric cancer Diseases of the Esophagus, August 28, 2014    Clinical Article

7 Strength and body weight in US children and adolescents Pediatrics, August 28, 2014    Clinical Article

8 Shorter time since inflammatory bowel disease diagnosis in children is associated with lower mental health in parents Acta Pediatrica, August 28, 2014    Clinical Article

9 The combined surgical and medical treatment of fistulising perianal Crohn's disease Alimentary Pharmacology and Therapeutics, August 28, 2014    Review Article

10 Use of chemotherapy and radiofrequency ablation to treat colorectal cancer metastases: A retrospective review of The Ottawa Hospital Cancer Centre over 7 years Full Text Current Oncology, August 28, 2014    Clinical Article

11 Abdominal infections in the intensive care unit: Characteristics, treatment and determinants of outcome Full Text BMC Infectious Diseases, August 28, 2014    Clinical Article

12 No increased risk of hepatocellular carcinoma in cirrhosis due to Wilson disease during long-term follow-up Journal of Gastroenterology and Hepatology, August 28, 2014    Clinical Article

13 Mortality and causes of death in patients with inflammatory bowel disease: A nationwide register study in Finland Journal of Crohn's and Colitis, August 28, 2014    Clinical Article

14 Genetic variation in prostaglandin synthesis and related pathways, NSAID use and colorectal cancer risk in the Colon Cancer Family Registry Carcinogenesis, August 28, 2014    Clinical Article

15 Chromoendoscopy for colorectal cancer surveillance in patients with inflammatory bowel disease Current Gastroenterology Reports, August 28, 2014    Review Article

16 Neurotensin-regulated miR-133{alpha} is involved in proinflammatory signalling in human colonic epithelial cells and in experimental colitis Gut, August 28, 2014    Clinical Article

17 Does the WHO 2010 classification of pancreatic neuroendocrine neoplasms accurately characterize pancreatic neuroendocrine carcinomas? Journal of Gastroenterology, August 28, 2014    Clinical Article

18 Evaluating informed consent for colonoscopy Surgical Laparoscopy, Endoscopy & Percutaneous Techniques, August 28, 2014    Clinical Article

19 Pharmacogenomic modeling of circulating tumor and invasive cells for prediction of chemotherapy response and resistance in pancreatic cancer Clinical Cancer Research, August 28, 2014    Clinical Article

20 An insight into the gastrointestinal component of fibromyalgia: Clinical manifestations and potential underlying mechanisms Rheumatology International, August 28, 2014    Clinical Article

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Highlights in Gastroenterology

KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

Increased MMP-9 expression associated with poor prognosis in CRC

As reported in the World Journal of Surgical Oncology, the expression of MMP-9 in colon cancer tissues was increased compared to distal normal mucosa (69.1% vs. 2.9%). Increased MMP-9 expression was associated with lymph node metastasis, Duke stage, and decreased survival.

Risk factors for CHC-related death identified

As reported in the World Journal of Gastroenterology, the following risk factors for chronic hepatitis C (CHC)-related deaths have been identified (n=8250 CHC patients; n=144 CHC-related deaths): α-IFN therapy (AOR=0.53); liver cirrhosis (AOR=2.89); hepatocellular carcinoma versus CHC (AOR=8.82); hypertension (AOR=1.76); alcohol consumption (AOR=1.73); and HBsAg positivity (AOR=22.28).

Other Topics in Gastroenterology

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