1A meta-analysis of the utility of C-reactive protein, erythrocyte sedimentation rate, fecal calprotectin, and fecal lactoferrin to exclude inflammatory bowel disease in adults with IBSThe American Journal of Gastroenterology  Clinical Article  Evidence Based Medicine
2Irritable bowel syndrome: a clinical reviewJAMA  Clinical Article  Evidence Based Medicine
3Differentiation of functional constipation and constipation predominant irritable bowel syndrome based on Rome III criteria: a population-based studyAlimentary Pharmacology and Therapeutics  Clinical Article
4Tenofovir rescue therapy in pregnant females with chronic hepatitis BWorld Journal of Gastroenterology  Full Text  Clinical Article
5The efficacy of a second anti-TNF in patients with inflammatory bowel disease whose previous anti-TNF treatment has failedAlimentary Pharmacology and Therapeutics  Evidence Based Medicine  Review Article
6Natural history of bleeding risk in colonic diverticulosis patients: a long-term colonoscopy-based cohort studyAlimentary Pharmacology and Therapeutics  Clinical Article
7Risk factors for acquisition of multidrug-resistant bacteria in patients with anastomotic leakage after colorectal cancer surgeryInternational Journal of Colorectal Disease  Clinical Article
8Impact of retroflexion vs. second forward view examination of the right colon on adenoma detection: a comparison studyThe American Journal of Gastroenterology  Clinical Article
9Hepatitis B virus reactivation and hepatitis in gastrointestinal cancer patients after chemotherapyCancer Chemotherapy and Pharmacology  Clinical Article
10Medical treatment versus surgery for treatment of gastroesophageal reflux diseaseTechniques in Gastrointestinal Endoscopy  Clinical Article
1Understanding how the stomach responds to injury could help target therapy against gastric damageAmerican Gastroenterological Association News
2Whole genome sequencing of pancreatic ductal adenocarcinomasEuropean Society for Medical Oncology News
3Mapping the gut microbiome to better understand its role in obesityGladstone Institutes News
4Gut bacteria may decrease weight loss from bariatric surgery: New study by Cedars-Sinai investigator presented at ENDO 2015 this weekCedars-Sinai
5Gut bacteria may decrease weight loss from bariatric surgeryCedars-Sinai
6Liquid biopsy to improve colorectal cancer careAgency for Science, Technology and Research (A*STAR) News
7Gut bacteria may contribute to diabetes in black malesUniversity of Illinois at Chicago Health News
8Media statement regarding CRE and duodenoscopeCedars-Sinai
9Prescription drug-induced liver failure is uncommon; over-the-counter medications and dietary/herbal supplements are most common causes, Penn study findsPenn Medicine
10Transmission of hepatitis C virus associated with surgical procedures - New Jersey 2010 and Wisconsin 2011Morbidity and Mortality Weekly Report

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KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

Risk factors for intra-abdominal abscesses in Crohn’s disease

As reported in Digestion, uncontrolled CRP at week 14 of therapy with infliximab (OR=1.36) and early loss of response to infliximab (OR=5.36) are independent risk factors for intra-abdominal abscesses in patients with Crohn’s disease.

Risk factors for CHC-related death identified

As reported in the World Journal of Gastroenterology, the following risk factors for chronic hepatitis C (CHC)-related deaths have been identified (n=8250 CHC patients; n=144 CHC-related deaths): α-IFN therapy (AOR=0.53); liver cirrhosis (AOR=2.89); hepatocellular carcinoma versus CHC (AOR=8.82); hypertension (AOR=1.76); alcohol consumption (AOR=1.73); and HBsAg positivity (AOR=22.28).

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Clinical Pearls

Clinical Pearl from Smartest DocCentral adiposity is a risk factor for the development of erosive esophagitis, Barrett’s esophagus and esophageal adenocarcinoma.

Clinical Pearl from Smartest DocEs besteht ein umgekehrter Zusammenhang zwischen der Rate der Screening-Untersuchungen und der Inzidenz des Kolorektalkarzinoms.

Clinical Pearl from Smartest DocEndoscopic reception of early-stage neoplasia in Barrett’s esophagus is important for staging.

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List