The Latest Journal Articles in Gastroenterology

1Oral prolonged release beclomethasone dipropionate and prednisone in the treatment of active ulcerative colitis: Results from a double-blind, randomized, parallel group studyThe American Journal of Gastroenterology, April 17, 2015  Clinical Article
2Effectiveness of bevacizumab added to standard chemotherapy in metastatic colorectal cancer: final results for first-line treatment from the ITACa randomized clinical trialAnnals of Oncology, April 17, 2015  Clinical Article
3Long-term safety of proton pump inhibitor therapy assessed under controlled, randomised clinical trial conditions: data from the SOPRAN and LOTUS studiesAlimentary Pharmacology and Therapeutics, April 17, 2015  Clinical Article
4Colestyramine vs. hydroxypropyl cellulose in patients with functional chronic watery diarrhoeaAlimentary Pharmacology and Therapeutics, April 17, 2015  Clinical Article
5Gut-directed hypnotherapy in the management of irritable bowel syndrome and inflammatory bowel diseaseAlimentary Pharmacology and Therapeutics, April 17, 2015  Review Article
6Double blind exploratory study on lipogenesis in preterm infants on parenteral nutrition with a lipid emulsion containing 10% fish oilClinical Nutrition, April 17, 2015  Clinical Article
7Comparison of once a day rifaximin to twice a day dosage in prevention of recurrence of hepatic encephalopathy in patients with chronic liver diseaseJournal of Gastroenterology and Hepatology, April 17, 2015  Clinical Article
8Improvement of nonalcoholic fatty liver disease with carnitine-orotate complex in type 2 diabetes (CORONA): A randomized controlled trialDiabetes Care, April 17, 2015  Clinical Article
9Analysis of the relative contribution of phagocytosis, LC3-associated phagocytosis, and canonical autophagy during Helicobacter pylori infection of macrophagesHelicobacter, April 17, 2015  Clinical Article
10Open-label prospective study of the safety and efficacy of glass-based yttrium 90 radioembolization for infiltrative hepatocellular carcinoma with portal vein thrombosisCancer, April 17, 2015  Clinical Article
1New treatment for common digestive condition Barrett's OesophagusUniversity of Warwick Health and Medicine News, April 17, 2015
2New research sheds light on how popular probiotic benefits the gutUniversity of Maryland School of Medicine News, April 17, 2015
3NIH study finds genetic link for rare intestinal cancerNIH News, April 17, 2015
4Proton pump inhibitors are associated with an increased risk of acute kidney failure and acute interstitial nephritis in older patientsSt. Michael's Hospital, April 17, 2015
5CNIO links telomeres to the origins of liver diseases such as chronic hepatitis and cirrhosisCentro Nacional de Investigaciones Oncologicas News, April 17, 2015
6Exercise key to fighting fat in the liver and gutThe University of Sydney News, April 16, 2015
7New potential approaches to treatment for primary sclerosing cholangitisMedical University of Vienna, April 16, 2015
8“Body on a Chip” project update: Video of mini hearts and liversWake Forest Baptist Medical Center News, April 16, 2015
9Creating profile to identify patients most at risk of developing pancreatic cancerMayo Clinic, April 15, 2015
10Can humans get norovirus from their dogs?American Society for Microbiology News, April 15, 2015

Show Me:

Increased MMP-9 expression associated with poor prognosis in CRC

As reported in the World Journal of Surgical Oncology, the expression of MMP-9 in colon cancer tissues was increased compared to distal normal mucosa (69.1% vs. 2.9%). Increased MMP-9 expression was associated with lymph node metastasis, Duke stage, and decreased survival.

Calcium reduces CRC risk

As reported in the International Journal of Cancer, there is an 8% reduction in CRC risk with each 300 mg/d increase in calcium intake based on 15 studies involving 12305 patients who took 250-1900 mg of calcium/day over a 3.3-16 year follow-up period. The beneficial effect extended beyond 1000 mg/d.

KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

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Clinical Pearls

Clinical Pearl from Smartest DocFatty pancreas is difficult to assess.

Clinical Pearl from Smartest DocH. pylori does not appear to be involved in the pathogenesis of oral lichen planus.

Clinical Pearl from Smartest DocThe only known precursor for esophageal adenocarcinoma is Barrett’s esophagus.

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