We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Population pharmacokinetics-pharmacodynamics of vedolizumab in patients with ulcerative colitis and Crohn's diseaseAlimentary Pharmacology and Therapeutics, May 22, 2015  Clinical Article
2Long-term safety of oral nucleos(t)ide analogues for patients with chronic hepatitis B – a cohort study of 53,500 subjectsHepatology, May 22, 2015  Clinical Article
3Constipation prophylaxis reduces length of stay in elderly hospitalized heart failure patients with home laxative useJournal of Gastroenterology and Hepatology, May 22, 2015  Clinical Article
4Persistent reactive thrombocytosis may increase the risk of coronary artery disease among inflammatory bowel disease patientsDigestive Diseases and Sciences, May 22, 2015  Clinical Article
5Pegylated interferon alfa for chronic hepatitis B: Systematic review and meta-analysisJournal of Viral Hepatitis, May 22, 2015  Evidence Based Medicine  Review Article
6Gastrointestinal and hepatic manifestations of Ebola virus infectionDigestive Diseases and Sciences, May 22, 2015  Review Article
7Thyroid function is associated with non-alcoholic fatty liver disease in chronic hepatitis B infected subjectsJournal of Gastroenterology and Hepatology, May 22, 2015  Clinical Article
8Epidemiology of pediatric functional abdominal pain disorders: a meta-analysisPLOS ONE, May 22, 2015  Evidence Based Medicine  Review Article
9Serum diamine oxidase activity as a predictor of gastrointestinal toxicity and malnutrition due to anticancer drugsJournal of Gastroenterology and Hepatology, May 22, 2015  Clinical Article
10Post-diagnostic oral bisphosphonate use and colorectal cancer mortality: a population-based cohort study within the UK Clinical Practice Research DatalinkBritish Journal of Cancer, May 22, 2015  Clinical Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1In study, skipping meals is linked to abdominal weight gainOhio State University News, May 21, 2015
2Helping doctors predict what's next for patients diagnosed with Hepatitis CUniversity of Michigan Health System, May 21, 2015
3Study reveals intestinal bacteria succession during recovery from cholera in BangladeshMassachusetts General Hospital, May 21, 2015
4Liver-sparing operation associated with higher survival rates in cancer patientsAmerican College of Surgeons News, May 20, 2015
5University Hospitals Seidman Cancer Center study finds non-invasive colon cancer screening may be promising for African AmericansUniversity Hospitals Case Medical Center News, May 20, 2015
6New targeted treatment IMMU-130 shows promise in patients with metastatic colon cancerFox Chase Cancer Center News, May 20, 2015
7Expert alert – precision medicine and obesityMayo Clinic, May 20, 2015
8First noninvasive early detection of liver cancer developed by Georgia State researchersGeorgia State University News, May 20, 2015
9VCU-developed compound continues phase 1 clinical trialsVirginia Commonwealth University News, May 20, 2015
10Study finds how pancreatic cancer spreads to liverCornell University Health News, May 20, 2015

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Infliximab is effective in corticosteroid-refractory ulcerative colitis

As reported in the Journal of Crohn’s & Colitis, treatment of corticosteroid-refractory ulcerative colitis patients with 3 doses of infliximab (n=113) resulted in short- (3 months) and long-term (12 months) colectomy rates of 18.6% and 25.6%, respectively. The RR of colectomy in patients with an elevated CRP and severe endoscopic lesions was 2.15 and 5.13, respectively.

Increased MMP-9 expression associated with poor prognosis in CRC

As reported in the World Journal of Surgical Oncology, the expression of MMP-9 in colon cancer tissues was increased compared to distal normal mucosa (69.1% vs. 2.9%). Increased MMP-9 expression was associated with lymph node metastasis, Duke stage, and decreased survival.

SCCA-IgM predicts survival in HCC patients

As reported in the Journal of Gastroenterology & Hepatology, SCCA-IgM levels are elevated in patients with hepatocellular carcinoma (HCC) compared to patients with cirrhosis and healthy controls. Not only does the SCCA-IgM level predict overall and progression-free survival in HCC patients, but the sensitivity of SCCA-IgM in patients with HCC was 2-fold greater than AFP. A decline in SCCA-IgM levels was shown to be associated with response to treatment.

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Clinical Pearl from Smartest DocThere is a strong correlation between the locations of colorectal cancer and synchronous adenomas.

Clinical Pearl from Smartest DocCough and vomiting are common side effects of rabeprazole in pediatric GERD.

Clinical Pearl from Smartest DocGabapentin is a first-tier therapy for functional gastrointestinal disorders in children.

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