Gastroenterology News Articles

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The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists. Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in Gastroenterology. In addition to general news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.

Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 A large-scale, prospective, observational study of leukocytapheresis for ulcerative colitis: Treatment outcomes of 847 patients in clinical practice Journal of Crohn's and Colitis, September 2, 2014    Clinical Article

2 Fatigue during treatment for hepatitis C virus: Results of self-reported fatigue severity in two Phase IIb studies of simeprevir treatment in patients with hepatitis C virus genotype 1 infection Full Text BMC Infectious Diseases, September 2, 2014    Clinical Article

3 Telbivudine plus pegylated interferon alfa-2a in a randomized study in chronic hepatitis B was associated with unexpected high rate of peripheral neuropathy Journal of Hepatology, September 2, 2014    Clinical Article

4 Women with celiac disease present with fertility problems no more often than women in the general population Gastroenterology, September 2, 2014    Clinical Article

5 Surveillance in patients with long-segment Barrett's oesophagus: a cost-effectiveness analysis Gut, September 2, 2014    Clinical Article

6 Patient and physician views on the quality of care in inflammatory bowel disease: Results from SOLUTION-1, a prospective IG-IBD study Journal of Crohn's and Colitis, September 2, 2014    Clinical Article

7 Lenalidomide can improve the anti-tumor activity of sorafenib in hepatocellular carcinoma through immune modulation Journal of Gastroenterology and Hepatology, September 2, 2014    Clinical Article

8 Patterns in the use of low-dose acetylsalicylic acid and other therapies following upper gastrointestinal bleeding American Journal of Cardiovascular Drugs, September 2, 2014    Clinical Article

9 A population-based study of incidence, risk factors, clinical spectrum, and outcomes of ischemic colitis Clinical Gastroenterology and Hepatology , September 2, 2014    Clinical Article

10 Association between oral leukoplakia and upper gastrointestinal cancers: A 28-year follow-up study in the Linxian General Population Trial Oral Oncology , September 2, 2014    Clinical Article

11 The use of fidaxomicin for treatment of relapsed Clostridium difficile infections in patients with cancer Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, September 2, 2014    Clinical Article

12 High definition plus colonoscopy combined with i-scan tone enhancement vs. high definition colonoscopy for colorectal neoplasia: A randomized trial Digestive and Liver Diseases, September 2, 2014    Clinical Article

13 Poor outcomes in hospitalized patients with gastrointestinal bleeding: impact of baseline risk, bleeding severity, and process of care The American Journal of Gastroenterology, September 2, 2014    Clinical Article

14 Acid infusion into the esophagus increases the number of meal-induced transient lower esophageal sphincter relaxations (TLESRs) in healthy volunteers Neurogastroenterology & Motility, September 2, 2014    Clinical Article

15 Vitamin D counteracts fibrogenic TGF-{beta} signalling in human hepatic stellate cells both receptor-dependently and independently Gut, September 2, 2014

16 Natural course vs interventions to clear common bile duct stones: Data from the Swedish registry for gallstone surgery and endoscopic retrograde cholangiopancreatography (GallRiks) JAMA Surgery, September 2, 2014    Review Article

17 Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study Gut, September 2, 2014    Clinical Article

18 Cost-utility analysis of endoscopic surveillance of patients with gastric premalignant conditions Helicobacter, September 2, 2014    Clinical Article

19 Excess of proximal microsatellite-stable colorectal cancer in African Americans from a multi-ethnic study Clinical Cancer Research, September 2, 2014    Clinical Article

20 Identification of conserved residues in hepatitis C virus envelope glycoprotein E2 that modulate virus dependence on CD81 and SRB1 entry factors Journal of Virology, September 2, 2014    Clinical Article

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Highlights in Gastroenterology

SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

Infliximab is effective in corticosteroid-refractory ulcerative colitis

As reported in the Journal of Crohn’s & Colitis, treatment of corticosteroid-refractory ulcerative colitis patients with 3 doses of infliximab (n=113) resulted in short- (3 months) and long-term (12 months) colectomy rates of 18.6% and 25.6%, respectively. The RR of colectomy in patients with an elevated CRP and severe endoscopic lesions was 2.15 and 5.13, respectively.

Increased MMP-9 expression associated with poor prognosis in CRC

As reported in the World Journal of Surgical Oncology, the expression of MMP-9 in colon cancer tissues was increased compared to distal normal mucosa (69.1% vs. 2.9%). Increased MMP-9 expression was associated with lymph node metastasis, Duke stage, and decreased survival.

Other Topics in Gastroenterology

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