We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Population pharmacokinetics of infliximab in patients with inflammatory bowel disease: Potential implications for dosing in clinical practiceAlimentary Pharmacology and Therapeutics, July 03, 2015  Clinical Article
2Association of baseline vitamin D levels with clinical parameters and treatment outcomes in chronic hepatitis BJournal of Hepatology, July 03, 2015  Clinical Article
3Dietary polyamine intake and colorectal cancer risk in postmenopausal womenAmerican Journal of Clinical Nutrition, July 03, 2015  Clinical Article
4Cost-effectiveness of strategies for testing current hepatitis C virus infectionHepatology, July 03, 2015  Clinical Article
5Effects of preceding endoscopic mucosal resection on the efficacy and safety of radiofrequency ablation for treatment of Barrett's esophagus: results from the United States Radiofrequency Ablation RegistryDiseases of the Esophagus, July 03, 2015  Clinical Article
6Phase II study of trastuzumab in combination with S-1 and cisplatin in the first-line treatment of human epidermal growth factor receptor HER2-positive advanced gastric cancerCancer Chemotherapy and Pharmacology, July 03, 2015  Clinical Article
7Trastuzumab in combination with docetaxel/cisplatin/S-1 (DCS) for patients with HER2-positive metastatic gastric cancer: Feasibility and preliminary efficacyCancer Chemotherapy and Pharmacology, July 03, 2015  Clinical Article
8Immunogenicity of an investigational hepatitis B vaccine with a toll-like receptor 9 agonist adjuvant (HBsAg-1018) compared with a licensed hepatitis B vaccine in subpopulations of healthy adults 18-70 years of ageVaccine , July 03, 2015  Clinical Article
9Combined Analysis of the Prevalence of drug Resistant HBV in antiviral therapy Experienced patients in Europe (CAPRE)The Journal of Infectious Diseases, July 03, 2015  Clinical Article
10Protease inhibitors to treat hepatitis C in the Swiss HIV Cohort Study: High efficacy but low treatment uptakeHIV Medicine, July 03, 2015  Clinical Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Anxiety increases the risk of gastrointestinal infection and long-term complicationsFlanders Institute for Biotechnology (VIB) News, July 03, 2015
2World GI 2015: Patients with lowest BMI have shortest survival in pooled analysis of bevacizumab in metastatic colorectal cancerEuropean Society for Medical Oncology News, July 03, 2015
3World GI 2015: SENRI trial opens window to evaluate NK1 antagonists for emesis prevention in oxaliplatin chemotherapyEuropean Society for Medical Oncology News, July 03, 2015
4Pinaverium shows promising results for treatment of irritable bowel syndromeAmerican Gastroenterological Association News, July 02, 2015
5Spouses & relatives of celiac disease patients at risk for autoimmune diseasesAmerican Gastroenterological Association News, July 02, 2015
6National study finds life-threatening barriers in access to breakthrough drugsThe Miriam Hospital, July 02, 2015
7Public health surveillance system may seriously underestimate cases of acute hepatitis C infectionMassachusetts General Hospital, July 02, 2015
8Study finds no association between amylase genes, obesityBroad Institute News, July 02, 2015
9Antibiotic treatments could affect pediatric development, animal study suggestsThe Jackson Laboratory News, July 02, 2015
10New hepatitis C treatment needs no antiviral boostJohns Hopkins Medicine, July 02, 2015

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Infliximab is effective in corticosteroid-refractory ulcerative colitis

As reported in the Journal of Crohn’s & Colitis, treatment of corticosteroid-refractory ulcerative colitis patients with 3 doses of infliximab (n=113) resulted in short- (3 months) and long-term (12 months) colectomy rates of 18.6% and 25.6%, respectively. The RR of colectomy in patients with an elevated CRP and severe endoscopic lesions was 2.15 and 5.13, respectively.

KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

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Clinical Pearls

Clinical Pearl from Smartest DocPreoperative bile duct obstruction in patients undergoing Frey’s procedure for chronic pancreatitis is associated with long-term endocrine function impairment.

Clinical Pearl from Smartest DocTo date, there is no definitive recommendation for noninvasive imaging of liver fat in children.

Clinical Pearl from Smartest DocFOXP3 mRNA levels in H. pylori(+) gastritis correlate positively with bacterial density.

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