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The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists

  • Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in your uniquely diverse field. In addition to general gastroenterology news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.
  • MDLinx Gastroenterology exclusive content includes: Monthly highlights of the "can't miss" articles chosen by our physician editor, D. Scott Cunningham, MD, PhD; clinical pearls from The Smartest Internist and Smartest Family Physician daily competitions, a collaboration from the editors of MDLinx and Cleveland Clinic Center for Continuing Education; and pearls from our Pediatrics Physician Review quizzes.

Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 Escalation to weekly dosing recaptures response in adalimumab-treated patients with moderately to severely active ulcerative colitis Alimentary Pharmacology and Therapeutics, July 23, 2014    Clinical Article

2 Randomized trial of asunaprevir plus peginterferon alfa and ribavirin for previously untreated genotype 1 or 4 chronic hepatitis C Journal of Hepatology, July 23, 2014    Clinical Article

3 Accuracy, safety, and tolerability of tissue collection by cytosponge vs endoscopy for evaluation of eosinophilic esophagitis Clinical Gastroenterology and Hepatology , July 23, 2014    Clinical Article

4 Mediterranean diet and non-alcoholic fatty liver disease Clinical Nutrition, July 23, 2014    Clinical Article

5 Randomized trial of the effects of individual nutritional counseling in cancer patients Clinical Nutrition, July 23, 2014    Clinical Article

6 Combination of microtubule associated protein-tau and β-tubulin III predicts chemosensitivity of paclitaxel in patients with advanced gastric cancer European Journal of Cancer, July 23, 2014    Clinical Article

7 Trends in abdominal obesity among US children and adolescents Pediatrics, July 23, 2014    Clinical Article

8 Constipation-predominant irritable bowel syndrome: A review of current and emerging drug therapies Full Text World Journal of Gastroenterology, July 23, 2014    Review Article

9 Vaccination coverage against hepatitis A and B viruses, Streptococcus pneumoniae, seasonal flu, and A(H1N1)2009 pandemic influenza in HIV-infected patients Vaccine , July 23, 2014    Clinical Article

10 Goal-directed fluid therapy based on stroke volume variations improves fluid management and gastrointestinal perfusion in patients undergoing major orthopedic surgery Full Text Medical Principles and Practice, July 23, 2014    Clinical Article

11 Influence of provider discussion and specific recommendation on colorectal cancer screening uptake among U.S. adults Preventive Medicine, July 23, 2014    Clinical Article

12 Aberrant serum IgG glycosylation in chronic hepatitis B is associated with histological liver damage and is reversible by antiviral therapy The Journal of Infectious Diseases, July 23, 2014    Clinical Article

13 Redefining high-risk patients with stage II colon cancer by risk index and microRNA-21: results from a population-based cohort British Journal of Cancer, July 23, 2014    Clinical Article

14 Long intestinal tube splinting really prevent recurrence of postoperative adhesive small bowel obstruction? A study of 1071 cases The American Journal of Surgery, July 23, 2014    Clinical Article

15 The natural history of jaundice in predominantly breastfed infants Pediatrics, July 23, 2014    Clinical Article

16 OPERA: responses to peginterferon and ribavirin therapy in a subgroup of interferon-na├»ve patients with HIV/HCV genotype 2/3 co-infection in Italy Liver International, July 23, 2014    Clinical Article

17 Longitudinal predictors of colorectal cancer screening among participants in a randomized controlled trial Preventive Medicine, July 23, 2014    Clinical Article

18 Trends in mortality from chronic liver disease Annals of Epidemiology , July 23, 2014    Clinical Article

19 Diarrhoea in slum children: observation from a large diarrhoeal disease hospital in Dhaka, Bangladesh Tropical Medicine & International Health, July 23, 2014    Evidence Based Medicine

20 Histological analysis of appendices removed during interval appendectomy after conservative management of pediatric patients with acute appendicitis with an inflammatory mass or abscess Surgery Today, July 23, 2014    Clinical Article

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Clinical Pearls in Gastroenterology

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Highlights in Gastroenterology

Risk factors for CHC-related death identified

As reported in the World Journal of Gastroenterology, the following risk factors for chronic hepatitis C (CHC)-related deaths have been identified (n=8250 CHC patients; n=144 CHC-related deaths): α-IFN therapy (AOR=0.53); liver cirrhosis (AOR=2.89); hepatocellular carcinoma versus CHC (AOR=8.82); hypertension (AOR=1.76); alcohol consumption (AOR=1.73); and HBsAg positivity (AOR=22.28).

Elevated ?-GT predicts HCC in hepatitis C patients with sustained response

As reported in the Journal of Hepatology, an elevated baseline ɣ-GT level is the strongest predictor of developing HCC in non-cirrhotic patients with hepatitis C and a sustained virologic response (HR = 6.44), followed by age (HR = 3.68).

Decreased PTPN12 expression associated with poor prognosis in HCC

As reported in PLoS ONE, the expression of PTPN12 was decreased in hepatocellular carcinoma tissue samples compared with adjacent normal tissues. Furthermore, decreased PTPN12 expression was associated with tumor recurrence, decreased cancer-specific survival, and decreased recurrence-free survival.

Other Topics in Gastroenterology

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