We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Consecutive monitoring of faecal calprotectin during mesalazine suppository therapy for active rectal inflammation in ulcerative colitisAlimentary Pharmacology and Therapeutics, July 06, 2015  Clinical Article
2High cure rate with 24 weeks of daclatasvir-based quadruple therapy in treatment-experienced, null-responder patients with HIV/hepatitis C virus genotype 1/4 coinfection: The ANRS HC30 QUADRIH StudyClinical Infectious Diseases, July 06, 2015  Clinical Article
3Long-term treatment outcomes of patients infected with hepatitis C virus: A systematic review and meta-analysis of the survival benefit of achieving a sustained virological responseClinical Infectious Diseases, July 06, 2015  Evidence Based Medicine  Review Article
4Comparison of hepatic arterial infusion chemotherapy versus sorafenib monotherapy in patients with advanced hepatocellular carcinomaJournal of Digestive Diseases, July 06, 2015  Clinical Article
5High-dose chemoradiotherapy and watchful waiting for distal rectal cancer: a prospective observational studyThe Lancet Oncology, July 06, 2015  Clinical Article
6Psychomotor retardation and vulnerability to interferon alpha induced major depressive disorder: Prospective study of a chronic hepatitis C cohortJournal of Psychosomatic Research, July 06, 2015  Clinical Article  Evidence Based Medicine
7Phase I study of combination of pasireotide LAR + gemcitabine in locally advanced or metastatic pancreatic cancerCancer Chemotherapy and Pharmacology, July 06, 2015  Clinical Article
8Eighteen cases of wheat allergy and wheat-dependent exercise-induced urticaria/anaphylaxis sensitized by hydrolyzed wheat protein in soapInternational Journal of Dermatology, July 06, 2015  Clinical Article
9Ribavirin for chronic hepatitis prevention among patients with hematologic malignanciesEmerging Infectious Diseases, July 06, 2015  Full Text  Clinical Article
10Four-sample lactose hydrogen breath test for diagnosis of lactose malabsorption in irritable bowel syndrome patients with diarrheaWorld Journal of Gastroenterology, July 06, 2015  Full Text  Clinical Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1The importance of placebos to medical careBeth Israel Deaconess Medical Center, July 06, 2015
2Cause of acute liver failure in young children discoveredTechnische Universität München, July 06, 2015
3Singapore team's discovery of new genomic aberrations of gastric cancer could pave the way for precision medicineAgency for Science, Technology and Research (A*STAR) News, July 06, 2015
4Abdominal blood clots may indicate undiagnosed cancerAarhus University Health News, July 06, 2015
5World GI 2015: Studies confirm regorafenib benefit in pre-treated metastatic colorectal cancerEuropean Society for Medical Oncology News, July 06, 2015
6McMaster researchers test fecal transplantation to treat ulcerative colitisMcMaster University Faculty of Health Sciences News, July 06, 2015
7Discovery promises new treatments to thwart colon cancerSt. Jude Children's Research Hospital News, July 06, 2015
8World GI 2015: Second-line cetuximab active beyond progression in quadruple wild-type patients with metastatic colorectal cancerEuropean Society for Medical Oncology News, July 06, 2015
9Anxiety increases the risk of gastrointestinal infection and long-term complicationsFlanders Institute for Biotechnology (VIB) News, July 03, 2015
10World GI 2015: Patients with lowest BMI have shortest survival in pooled analysis of bevacizumab in metastatic colorectal cancerEuropean Society for Medical Oncology News, July 03, 2015

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KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

Elevated ?-GT predicts HCC in hepatitis C patients with sustained response

As reported in the Journal of Hepatology, an elevated baseline ɣ-GT level is the strongest predictor of developing HCC in non-cirrhotic patients with hepatitis C and a sustained virologic response (HR = 6.44), followed by age (HR = 3.68).

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Clinical Pearls

Clinical Pearl from Smartest DocCeliac disease may increase the risk of non-Hodgkin lymphoma and small-intestinal cancer.

Clinical Pearl from Smartest DocThe safety and efficacy of HCV therapy with interferon and ribavirin for patients with IBD are comparable to those of patients without IBD.

Clinical Pearl from Smartest DocRoutine endoscopic screening for Barrett’s esophagus is not recommended due to excessive healthcare costs.

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