We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Randomised clinical trial: a placebo-controlled study of intravenous golimumab induction therapy for ulcerative colitisAlimentary Pharmacology and Therapeutics, July 01, 2015  Clinical Article
2Effectiveness of sofosbuvir-based regimens in genotype 1 and 2 hepatitis C virus infection in 4026 U.S. VeteransAlimentary Pharmacology and Therapeutics, July 01, 2015  Clinical Article
3The Experience Sampling Method - a new digital tool for momentary symptom assessment in IBS: an exploratory studyNeurogastroenterology & Motility, July 01, 2015  Clinical Article
4Efficacy of a Chinese herbal medicine in providing adequate relief of constipation-predominant irritable bowel syndrome: A randomized controlled trialClinical Gastroenterology and Hepatology , July 01, 2015  Clinical Article
5Increased risk of preterm birth in women with autoimmune hepatitis – a nationwide cohort studyLiver International, July 01, 2015  Clinical Article
6Liver toxicity and risk of discontinuation in HIV/hepatitis C virus-coinfected patients receiving an etravirine-containing antiretroviral regimen: Influence of liver fibrosisHIV Medicine, July 01, 2015  Clinical Article
7Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intentAntiviral Research , July 01, 2015  Clinical Article
8Surveillance colonoscopy for colitis-associated dysplasia and cancer in ulcerative colitis patientsDigestive Endoscopy, July 01, 2015  Review Article
9Intestinal gas content and distribution in health and in patients with functional gut symptomsNeurogastroenterology & Motility, July 01, 2015  Clinical Article
10A Systematic Review of Integrated Traditional Chinese and Western Medicine for Managing Irritable Bowel SyndromeThe American Journal of Chinese Medicine (AJCM), July 01, 2015  Evidence Based Medicine  Review Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Protein's impact on colorectal cancer is dappledUC San Diego Health System, July 01, 2015
2Lack of sanitation for 2.4 billion people is undermining health improvementsWHO news, July 01, 2015
3Risk of bowel cancer reduced by taking aspirin for Lynch syndrome patientsUniversity of Melbourne News, June 29, 2015
4Tiny particles in blood useful for early diagnosis of pancreatic cancerThe University of Texas MD Anderson Cancer Center, June 26, 2015
5UAB among the first to enroll in national clinical trial for novel fecal incontinence treatmentUAB Medicine, June 26, 2015
6Maternal stress alters offspring gut and brain through vaginal microbiomeEndocrine Society News, June 26, 2015
7Study identifies multiple genetic changes linked to increased pancreatic cancer riskJohns Hopkins Medicine, June 26, 2015
8A gel that can make drugs last longerAgency for Science, Technology and Research (A*STAR) News, June 26, 2015
9Discovery targets dormant bowel cancer cells before they form secondary tumoursUniversity of Melbourne News, June 26, 2015
10New approach holds promise for earlier, easier detection of colorectal cancerCalifornia Institute of Technology News, June 26, 2015

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Infliximab is effective in corticosteroid-refractory ulcerative colitis

As reported in the Journal of Crohn’s & Colitis, treatment of corticosteroid-refractory ulcerative colitis patients with 3 doses of infliximab (n=113) resulted in short- (3 months) and long-term (12 months) colectomy rates of 18.6% and 25.6%, respectively. The RR of colectomy in patients with an elevated CRP and severe endoscopic lesions was 2.15 and 5.13, respectively.

Calcium reduces CRC risk

As reported in the International Journal of Cancer, there is an 8% reduction in CRC risk with each 300 mg/d increase in calcium intake based on 15 studies involving 12305 patients who took 250-1900 mg of calcium/day over a 3.3-16 year follow-up period. The beneficial effect extended beyond 1000 mg/d.

Increased MMP-9 expression associated with poor prognosis in CRC

As reported in the World Journal of Surgical Oncology, the expression of MMP-9 in colon cancer tissues was increased compared to distal normal mucosa (69.1% vs. 2.9%). Increased MMP-9 expression was associated with lymph node metastasis, Duke stage, and decreased survival.

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Clinical Pearls

Clinical Pearl from Smartest DocNeurological complications of bariatric procedures arise primarily from nutritional deficiencies.

Clinical Pearl from Smartest DocLaparoscopic resection is an option for locally advanced rectal cancer after neoadjuvant chemoradiotherapy.

Clinical Pearl from Smartest DocHigh serum 25-hydroxyvitamin D levels in postmenopausal women are inversely correlated with NAFLD.

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