The Latest Journal Articles in Gastroenterology

1Methotrexate use and risk of lung disease in psoriasis, psoriatic arthritis, and inflammatory bowel disease: systematic literature review and meta-analysis of randomised controlled trialsBMJ, April 27, 2015  Evidence Based Medicine  Review Article
2Association between severe portal hypertension and risk of liver decompensation in patients with hepatitis C, regardless of response to antiviral therapyClinical Gastroenterology and Hepatology , April 27, 2015  Clinical Article
3Dietary fibre and FODMAP-restricted diet in the management of constipation and irritable bowel syndromeAlimentary Pharmacology and Therapeutics, April 27, 2015  Review Article
4Vitamin D–binding protein and pancreatic cancer: a nested case-control studyAmerican Journal of Clinical Nutrition, April 27, 2015  Clinical Article
5Association between regular aspirin use and circulating markers of inflammation: a study within the prostate, lung, colorectal, and ovarian cancer screening trialCancer Epidemiology, Biomarkers & Prevention, April 27, 2015  Clinical Article
6Drug-drug interactions among hepatitis C virus (HCV) and human immunodeficiency virus (HIV) medicationsInfectious Diseases and Therapy, April 27, 2015  Full Text  Review Article
7Atopic allergic conditions and colorectal cancer risk in the multiethnic cohort studyAmerican Journal of Epidemiology, April 27, 2015  Clinical Article
8A phase I study of intraperitoneal nanoparticulate paclitaxel (Nanotax®) in patients with peritoneal malignanciesCancer Chemotherapy and Pharmacology, April 27, 2015  Clinical Article
9A double-blind, placebo-controlled randomized trial to evaluate the efficacy of docosahexaenoic acid supplementation on hepatic fat and associated cardiovascular risk factors in overweight children with nonalcoholic fatty liver diseaseNutrition, Metabolism & Cardiovascular Diseases, April 27, 2015  Clinical Article
10Direct-acting antiviral-based triple therapy on alpha-fetoprotein level in chronic hepatitis C patientsWorld Journal of Gastroenterology, April 27, 2015  Full Text  Clinical Article
1Altered bacteria may reduce inflammation and alleviate inflammatory bowel diseasesUF Health, April 27, 2015
2The intestine as the central organ in cases of food allergiesMedical University of Vienna, April 27, 2015
3Are hospitals doing all they can to prevent C. diff infections? Not yet, new study suggestsUniversity of Michigan Health System, April 27, 2015
4Genes influence survival in bowel cancer patientsCardiff University News, April 27, 2015
5Pancreatic cancer breakthrough: Scientists turn cancer cells into normal cellsSanford-Burnham Medical Research Institute News, April 24, 2015
6Delayed diagnosis of coeliac disease may put lives at risk: Is screening the solution?United European Gastroenterology News, April 24, 2015
7Protein identified that serves as a "brake" on inflammationSt. Jude Children's Research Hospital News, April 24, 2015
8Cirrhosis deaths drop 41 percent from 2002 to 2012UNC Health Care System, April 24, 2015
9Alcoholic hepatitis treatments fail to keep patients aliveImperial College London Health News, April 24, 2015
10Mouth, as well as gut, could hold key to liver disease flare-upsVirginia Commonwealth University News, April 24, 2015

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Increased MMP-9 expression associated with poor prognosis in CRC

As reported in the World Journal of Surgical Oncology, the expression of MMP-9 in colon cancer tissues was increased compared to distal normal mucosa (69.1% vs. 2.9%). Increased MMP-9 expression was associated with lymph node metastasis, Duke stage, and decreased survival.

Calcium reduces CRC risk

As reported in the International Journal of Cancer, there is an 8% reduction in CRC risk with each 300 mg/d increase in calcium intake based on 15 studies involving 12305 patients who took 250-1900 mg of calcium/day over a 3.3-16 year follow-up period. The beneficial effect extended beyond 1000 mg/d.

Risk factors for CHC-related death identified

As reported in the World Journal of Gastroenterology, the following risk factors for chronic hepatitis C (CHC)-related deaths have been identified (n=8250 CHC patients; n=144 CHC-related deaths): α-IFN therapy (AOR=0.53); liver cirrhosis (AOR=2.89); hepatocellular carcinoma versus CHC (AOR=8.82); hypertension (AOR=1.76); alcohol consumption (AOR=1.73); and HBsAg positivity (AOR=22.28).

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Clinical Pearls

Clinical Pearl from Smartest DocEtwa ein 1/3 aller stationären Patienten mit akuter Pankreatitis werden aufgrund von starken Schmerzen, lokalen Komplikationen oder Rezidiven erneut ins Krankenhaus aufgenommen.

Clinical Pearl from Smartest DocLedipasvir is a HCV NS5A inhibitor.

Clinical Pearl from Smartest DocPlasma 25-hydroxyvitamin-D-Mangel ist bei HIV/HCV-koinfizierten Patienten nicht mit HCV-Therapieversagen assoziiert.

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