The Latest Clinical Articles in Gastroenterology & GastroIntestinal

1Thiopurine metabolites variations during co-treatment with aminosalicylates for inflammatory bowel disease: Effect of N-acetyl transferase polymorphismsWorld Journal of Gastroenterology, March 30, 2015  Full Text  Clinical Article
2Improvement of health-related quality of life and work productivity in chronic hepatitis C patients with early and advanced fibrosis treated with ledipasvir and sofosbuvirJournal of Hepatology, March 30, 2015  Clinical Article
3A triple and quadruple therapy with doxycycline and bismuth for first-line treatment of Helicobacter pylori infection: A pilot studyHelicobacter, March 30, 2015  Clinical Article
4Chemotherapy treatment patterns, costs, and outcomes of patients with gastric cancer in the United States: a retrospective analysis of electronic medical record (EMR) and administrative claims dataGastric Cancer, March 30, 2015  Clinical Article
5Positive regulatory effects of perioperative probiotic treatment on postoperative liver complications after colorectal liver metastases surgery: a double-center and double-blind randomized clinical trialBMC Gastroenterology, March 30, 2015  Full Text  Clinical Article
6Different effect of smoking on genders in Crohn’s diseaseThe Turkish Journal of Gastroenterology, March 30, 2015  Full Text  Clinical Article
7The association of percentage energy from fat and colon cancer risk among members of the US militaryEuropean Journal of Cancer Prevention, March 30, 2015  Clinical Article
8Association between IL28B polymorphism, TNF and biomarkers of insulin resistance in chronic hepatitis C-related insulin resistanceJournal of Viral Hepatitis, March 30, 2015  Clinical Article
9New therapeutic option for irritable bowel syndrome: Serum-derived bovine immunoglobulinWorld Journal of Gastroenterology, March 30, 2015  Full Text  Clinical Article
10Assessment of 35 children with abdominal tuberculosisThe Turkish Journal of Gastroenterology, March 30, 2015  Full Text  Review Article
1Researchers reverse type 2 diabetes and fatty liver diseaseUniversity of Copenhagen Faculty of Health and Medical Sciences News, March 30, 2015
2How our DNA may prevent bowel cancerUniversity of Melbourne News, March 30, 2015
3American College of Physicians joins HHS in accelerating alternative payment methods through ‘Health Care Payment Learning and Action Network’ American College of Physicians News, March 26, 2015
4Exciting data presented at the 4th Gut Microbiota For Health SummitAmerican Gastroenterological Association News, March 23, 2015
5NCCS pioneers new drug regimen which reduces toxicities for renal cancer patientsNational Cancer Centre Singapore News, March 23, 2015
6Tumour determination in bowel cancer: Blood test replaces surgeryMedical University of Vienna, March 19, 2015
7Potential drug target found to prevent bowel cancer spreadMonash University News, March 19, 2015
8Does aspirin prevent colorectal cancer? Depends on your DNAFred Hutchinson Cancer Research Center News, March 19, 2015
9Rebooting cell programming can reverse liver failure, says Children's Hospital/Pitt studyUPMC, March 19, 2015
10A single-cell breakthroughUNC Health Care System, March 19, 2015

Show Me:

Infliximab is effective in corticosteroid-refractory ulcerative colitis

As reported in the Journal of Crohn’s & Colitis, treatment of corticosteroid-refractory ulcerative colitis patients with 3 doses of infliximab (n=113) resulted in short- (3 months) and long-term (12 months) colectomy rates of 18.6% and 25.6%, respectively. The RR of colectomy in patients with an elevated CRP and severe endoscopic lesions was 2.15 and 5.13, respectively.

SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

Decreased PTPN12 expression associated with poor prognosis in HCC

As reported in PLoS ONE, the expression of PTPN12 was decreased in hepatocellular carcinoma tissue samples compared with adjacent normal tissues. Furthermore, decreased PTPN12 expression was associated with tumor recurrence, decreased cancer-specific survival, and decreased recurrence-free survival.

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Clinical Pearls

Clinical Pearl from Smartest DocELF and Fibroscan are more accurate than IP10 in predicting severe hepatitis C after liver transplantation.

Clinical Pearl from Smartest DocPediatric appendicitis patients with SIRS may be at greater risk for intra-abdominal abscesses.

Clinical Pearl from Smartest DocNearly 40% of patients with primary biliary cirrhosis/autoimmune hepatitis do not respond to initial therapy with ursodeoxycholic acid.

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