The Latest Journal Articles in Gastroenterology

1Oral prolonged release beclomethasone dipropionate and prednisone in the treatment of active ulcerative colitis: Results from a double-blind, randomized, parallel group studyThe American Journal of Gastroenterology, April 17, 2015  Clinical Article
2Effectiveness of bevacizumab added to standard chemotherapy in metastatic colorectal cancer: final results for first-line treatment from the ITACa randomized clinical trialAnnals of Oncology, April 17, 2015  Clinical Article
3Long-term safety of proton pump inhibitor therapy assessed under controlled, randomised clinical trial conditions: data from the SOPRAN and LOTUS studiesAlimentary Pharmacology and Therapeutics, April 17, 2015  Clinical Article
4Colestyramine vs. hydroxypropyl cellulose in patients with functional chronic watery diarrhoeaAlimentary Pharmacology and Therapeutics, April 17, 2015  Clinical Article
5Gut-directed hypnotherapy in the management of irritable bowel syndrome and inflammatory bowel diseaseAlimentary Pharmacology and Therapeutics, April 17, 2015  Review Article
6Double blind exploratory study on lipogenesis in preterm infants on parenteral nutrition with a lipid emulsion containing 10% fish oilClinical Nutrition, April 17, 2015  Clinical Article
7Comparison of once a day rifaximin to twice a day dosage in prevention of recurrence of hepatic encephalopathy in patients with chronic liver diseaseJournal of Gastroenterology and Hepatology, April 17, 2015  Clinical Article
8Improvement of nonalcoholic fatty liver disease with carnitine-orotate complex in type 2 diabetes (CORONA): A randomized controlled trialDiabetes Care, April 17, 2015  Clinical Article
9Analysis of the relative contribution of phagocytosis, LC3-associated phagocytosis, and canonical autophagy during Helicobacter pylori infection of macrophagesHelicobacter, April 17, 2015  Clinical Article
10Open-label prospective study of the safety and efficacy of glass-based yttrium 90 radioembolization for infiltrative hepatocellular carcinoma with portal vein thrombosisCancer, April 17, 2015  Clinical Article
1New treatment for common digestive condition Barrett's OesophagusUniversity of Warwick Health and Medicine News, April 17, 2015
2New research sheds light on how popular probiotic benefits the gutUniversity of Maryland School of Medicine News, April 17, 2015
3NIH study finds genetic link for rare intestinal cancerNIH News, April 17, 2015
4Proton pump inhibitors are associated with an increased risk of acute kidney failure and acute interstitial nephritis in older patientsSt. Michael's Hospital, April 17, 2015
5CNIO links telomeres to the origins of liver diseases such as chronic hepatitis and cirrhosisCentro Nacional de Investigaciones Oncologicas News, April 17, 2015
6Exercise key to fighting fat in the liver and gutThe University of Sydney News, April 16, 2015
7New potential approaches to treatment for primary sclerosing cholangitisMedical University of Vienna, April 16, 2015
8“Body on a Chip” project update: Video of mini hearts and liversWake Forest Baptist Medical Center News, April 16, 2015
9Creating profile to identify patients most at risk of developing pancreatic cancerMayo Clinic, April 15, 2015
10Can humans get norovirus from their dogs?American Society for Microbiology News, April 15, 2015

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SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

Risk factors for CHC-related death identified

As reported in the World Journal of Gastroenterology, the following risk factors for chronic hepatitis C (CHC)-related deaths have been identified (n=8250 CHC patients; n=144 CHC-related deaths): α-IFN therapy (AOR=0.53); liver cirrhosis (AOR=2.89); hepatocellular carcinoma versus CHC (AOR=8.82); hypertension (AOR=1.76); alcohol consumption (AOR=1.73); and HBsAg positivity (AOR=22.28).

SCCA-IgM predicts survival in HCC patients

As reported in the Journal of Gastroenterology & Hepatology, SCCA-IgM levels are elevated in patients with hepatocellular carcinoma (HCC) compared to patients with cirrhosis and healthy controls. Not only does the SCCA-IgM level predict overall and progression-free survival in HCC patients, but the sensitivity of SCCA-IgM in patients with HCC was 2-fold greater than AFP. A decline in SCCA-IgM levels was shown to be associated with response to treatment.

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Clinical Pearls

Clinical Pearl from Smartest DocDumping syndrome may occur after procedures involving at least partial gastric resection or bypass.

Clinical Pearl from Smartest DocFetal nutritional exposure can have lasting effects on the heritable risk of non-communicable diseases, including metabolic syndrome.

Clinical Pearl from Smartest DocDer Einsatz von Protonenpumpenhemmern erhöht bei Patienten mit Zirrhosis das Mortalitätsrisiko.