Gastroenterology News Articles

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The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists. Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in Gastroenterology. In addition to general news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.

Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 Tralokinumab for moderate-to-severe UC: a randomised, double-blind, placebo-controlled, phase IIa study Gut, October 21, 2014    Clinical Article

2 Response-guided boceprevir-based triple therapy in HIV/HCV-coinfected patients: The HIVCOBOC–RGT study The Journal of Infectious Diseases, October 21, 2014    Clinical Article

3 A new acupuncture method for management of irritable bowel syndrome: A randomized double blind clinical trial Journal of Research in Medical Sciences, October 21, 2014    Clinical Article

4 The impact of abdominal pain on global measures in patients with chronic idiopathic constipation, before and after treatment with linaclotide: a pooled analysis of two randomised, double-blind, placebo-controlled, phase 3 trials Alimentary Pharmacology and Therapeutics, October 21, 2014    Clinical Article

5 The severity of irritable bowel syndrome or the presence of fibromyalgia influencing the perception of visceral and somatic stimuli Full Text BMC Gastroenterology, October 21, 2014    Clinical Article

6 Predictive factors of silent reflux in subjects with erosive esophagitis Digestive and Liver Diseases, October 21, 2014    Clinical Article

7 Sofosbuvir with peginterferon-ribavirin for 12 weeks in previously treated patients with hepatitis C genotype 2 or 3 and cirrhosis Hepatology, October 21, 2014    Clinical Article

8 A phase II study of the efficacy and safety of the combination therapy of the MEK inhibitor refametinib (BAY 86-9766) plus sorafenib for Asian patients with unresectable hepatocellular carcinoma Clinical Cancer Research, October 21, 2014    Clinical Article

9 Incidence of natural resistance mutations in na├»ve chronic hepatitis B patients: a systematic review and meta-analysis Journal of Gastroenterology and Hepatology, October 21, 2014    Evidence Based Medicine    Review Article

10 New diagnosis of chronic pancreatitis: risk of missing an underlying pancreatic cancer The American Journal of Gastroenterology, October 21, 2014    Clinical Article

11 Dynamic changes of the inflammation-based index predict mortality following chemoembolisation for hepatocellular carcinoma: a prospective study Alimentary Pharmacology and Therapeutics, October 21, 2014    Clinical Article

12 Hepatitis B virus sub-genotype A1 infection is characterized by high replication levels and rapid emergence of drug resistance in HIV-positive adults receiving first-line antiretroviral therapy in Malawi Clinical Infectious Diseases, October 21, 2014    Clinical Article

13 A preoperative serum signature of CEA+/CA125+/CA19-9 ≥1000 U/mL indicates poor outcome to pancreatectomy for pancreatic cancer International Journal of Cancer, October 21, 2014    Clinical Article

14 Allergy-related diseases and recurrent abdominal pain during childhood - a birth cohort study Alimentary Pharmacology and Therapeutics, October 21, 2014    Clinical Article

15 Strategies for the treatment of aorto-oesophageal fistula European Journal of Cardio-Thoracic Surgery, October 21, 2014    Clinical Article

16 Are IBD patients more likely to have a prior diagnosis of irritable bowel syndrome? Report of a case-control study in the General Practice Research Database United European Gastroenterology Journal, October 21, 2014    Clinical Article

17 Routine coagulation screening is an unnecessary step prior to ERCP in patients without biochemical evidence of jaundice; a cross-centre study International Journal of Surgery, October 21, 2014    Clinical Article

18 Acute HIV infection is beneficial for controlling chronic hepatitis B Clinical Infectious Diseases, October 21, 2014    Clinical Article

19 A systematic review of raltitrexed-based first-line chemotherapy in advanced colorectal cancer Anti-Cancer Drugs, October 21, 2014    Review Article

20 Advanced colonoscopic imaging using endocytoscopy Digestive Endoscopy, October 21, 2014    Review Article

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Highlights in Gastroenterology

KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

Infliximab is effective in corticosteroid-refractory ulcerative colitis

As reported in the Journal of Crohn’s & Colitis, treatment of corticosteroid-refractory ulcerative colitis patients with 3 doses of infliximab (n=113) resulted in short- (3 months) and long-term (12 months) colectomy rates of 18.6% and 25.6%, respectively. The RR of colectomy in patients with an elevated CRP and severe endoscopic lesions was 2.15 and 5.13, respectively.

Calcium reduces CRC risk

As reported in the International Journal of Cancer, there is an 8% reduction in CRC risk with each 300 mg/d increase in calcium intake based on 15 studies involving 12305 patients who took 250-1900 mg of calcium/day over a 3.3-16 year follow-up period. The beneficial effect extended beyond 1000 mg/d.

Other Topics in Gastroenterology

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