The Latest Clinical Articles in Gastroenterology & GastroIntestinal

1IBD-related work disability in the community: Prevalence, severity and predictive factors. A cross-sectional studyUnited European Gastroenterology Journal, March 27, 2015  Clinical Article
2Low-dose ramosetron accelerates gastric emptying in the early phase: A crossover study in healthy volunteers using a continuous real-time 13C breath test (BreathID System)The Turkish Journal of Gastroenterology, March 27, 2015  Full Text  Clinical Article
3Gastric polyps and polypoid lesions: Retrospective analysis of 36650 endoscopic procedures in 29940 patientsThe Turkish Journal of Gastroenterology, March 27, 2015  Full Text  Clinical Article
4Effect of DKT, a traditional Japanese herbal medicine, after total gastrectomy for gastric cancer: A multicenter, randomized, double-blind, placebo-controlled phase II trialJournal of the American College of Surgeons, March 27, 2015  Clinical Article
5Weekly pattern of emergency room admissions for peptic ulcers: A population-based studyWorld Journal of Gastroenterology, March 27, 2015  Full Text  Clinical Article
6Pharmacogenetic analysis of INT 0144 trial: association of polymorphisms with survival and toxicity in rectal cancer patients treated with 5-FU and radiationClinical Cancer Research, March 27, 2015  Clinical Article
7Sarcopenia is an independent risk factor of dysphagia in hospitalized older peopleGeriatrics and Gerontology International, March 27, 2015  Clinical Article
8BATF2 deficiency promotes progression in human colorectal cancer via activation of HGF/MET signaling: a potential rationale for combining MET inhibitors with IFNSClinical Cancer Research, March 27, 2015  Clinical Article
9Standardization of laparoscopic total mesorectal excision for rectal cancer: A structured international expert consensusAnnals of Surgery, March 27, 2015  Clinical Article
10Contribution of susceptibility variants at FCGR2A and 13q12 to the risk of relapse among Japanese patients with ulcerative colitisJournal of Gastroenterology, March 27, 2015  Clinical Article
1American College of Physicians joins HHS in accelerating alternative payment methods through ‘Health Care Payment Learning and Action Network’ American College of Physicians News, March 26, 2015
2Exciting data presented at the 4th Gut Microbiota For Health SummitAmerican Gastroenterological Association News, March 23, 2015
3NCCS pioneers new drug regimen which reduces toxicities for renal cancer patientsNational Cancer Centre Singapore News, March 23, 2015
4Tumour determination in bowel cancer: Blood test replaces surgeryMedical University of Vienna, March 19, 2015
5Potential drug target found to prevent bowel cancer spreadMonash University News, March 19, 2015
6Does aspirin prevent colorectal cancer? Depends on your DNAFred Hutchinson Cancer Research Center News, March 19, 2015
7Rebooting cell programming can reverse liver failure, says Children's Hospital/Pitt studyUPMC, March 19, 2015
8A single-cell breakthroughUNC Health Care System, March 19, 2015
9Penn vet team points to new colon cancer culpritUniversity of Pennsylvania News, March 18, 2015
10FDA approves Cholbam to treat rare bile acid synthesis disordersFDA Press Announcements, March 18, 2015

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Risk factors for CHC-related death identified

As reported in the World Journal of Gastroenterology, the following risk factors for chronic hepatitis C (CHC)-related deaths have been identified (n=8250 CHC patients; n=144 CHC-related deaths): α-IFN therapy (AOR=0.53); liver cirrhosis (AOR=2.89); hepatocellular carcinoma versus CHC (AOR=8.82); hypertension (AOR=1.76); alcohol consumption (AOR=1.73); and HBsAg positivity (AOR=22.28).

SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

Predictors of sustained binge drinking

As reported in Alcoholism: Clinical & Experimental Research, sustained binge drinkers have an earlier onset, drink monthly in secondary school, binged in their 20s, exhibit impulsivity and novelty-seeking, and have depressive symptoms during adolescence compared to those who stop binge drinking.

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Clinical Pearls

Clinical Pearl from Smartest DocChildren with suspected appendicitis and incompletely visualized appendices on ultrasound can be safely discharged home based on clinical findings.

Clinical Pearl from Smartest DocThe prevalence of GERD in those under 20 years of age is 4.4%.

Clinical Pearl from Smartest DocThe most commonly isolated organisms during cirrhotic bleeding are aerobic gram negative bacilli of enteric origin.

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