1Effect of proton-pump inhibitors on the risk of lower gastrointestinal bleeding associated with NSAIDs, aspirin, clopidogrel, and warfarinJournal of Gastroenterology  Clinical Article
2Flow cytometry detection of vitamin D receptor changes during vitamin D treatment in Crohn's diseaseClinical and Experimental Immunology  Clinical Article
3Systematic review and meta-analysis of histopathological predictive factors for lymph node metastasis in T1 colorectal cancerJournal of Gastroenterology  Evidence Based Medicine  Review Article
4Randomised clinical trial: Deep remission in biologic and immunomodulator naïve patients with Crohn's disease – a SONIC post hoc analysisAlimentary Pharmacology and Therapeutics  Clinical Article
5Impact of new oral anticoagulants on gastrointestinal bleeding in atrial fibrillation: A meta-analysis of interventional trialsDigestive and Liver Diseases  Clinical Article
6High C-reactive protein is associated with poor sleep quality independent of nocturnal symptoms in patients with inflammatory bowel diseaseDigestive Diseases and Sciences  Clinical Article
7Increased number of forkhead box P3+ tumor-infiltrating lymphocytes correlates with high preoperative albumin level and better survival in patients with stage II or III colorectal cancerTumor Biology  Clinical Article
8Morbidity after total gastrectomy: analysis of 238 patientsJournal of the American College of Surgeons  Review Article
9Pharmacokinetic interactions between telaprevir and antiretroviral drugs in HIV/HCV-coinfected patients with advanced liver fibrosis and prior HCV non-respondersInternational Journal of Antimicrobial Agents  Clinical Article
10Evaluation of the nutrition screening tool for childhood cancer (SCAN)Clinical Nutrition  Clinical Article
1Notes from the field: Cryptosporidiosis associated with consumption of unpasteurized goat milk - Idaho, 2014Morbidity and Mortality Weekly Report
2QMUL and Takeda announce research collaboration to develop new therapies in gastroenterologyQueen Mary University of London News
3Crohn's disease not exempt from racial disparitiesNationwide Children's Hospital
4Researchers find link between inflammation, tissue regeneration and wound repair responseUC San Diego Health System
5Yale researchers reverse type 2 diabetes and fatty liver disease in ratsYale School of Medicine News
6IU researchers: Pancreatic cancer patients with particular gene signature may benefit from personalized treatmentIndiana University School of Medicine News
7Widely used food additive promotes colitis, obesity and metabolic syndrome, research showsGeorgia State University News
8How the landscape of the pancreatic cancer genome is coming into viewGarvan Institute of Medical Research News
9Bariatric surgery affects risk of pregnancy complicationsKarolinska Institutet
10NewYork-Presbyterian Hospital/Weill Cornell Medical Center develops new procedure to alleviate common side effects for gastric bypass patientsNewYork-Presbyterian

Show Me:

SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

Infliximab is effective in corticosteroid-refractory ulcerative colitis

As reported in the Journal of Crohn’s & Colitis, treatment of corticosteroid-refractory ulcerative colitis patients with 3 doses of infliximab (n=113) resulted in short- (3 months) and long-term (12 months) colectomy rates of 18.6% and 25.6%, respectively. The RR of colectomy in patients with an elevated CRP and severe endoscopic lesions was 2.15 and 5.13, respectively.

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Clinical Pearls

Clinical Pearl from Smartest DocEtwa 50–70 % aller cholangiozellulären Karzinome entstehen im Hilusbereich.

Clinical Pearl from Smartest DocPatienten mit Barrett-Ösophagus, Raucher und adipöse Menschen zeigen eine erhöhte COX-2-Expression in der Ösophagus-Mukosa.

Clinical Pearl from Smartest DocH.Pylori-Stämme in der Mundhöhle stellen bei Kindern kein Reservoir für Infektionen dar.

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List