Hepatitis C

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Randomised clinical trial: a dose-ranging study of vonoprazan, a novel potassium-competitive acid blocker, vs. lansoprazole for the treatment of erosive oesophagitisAlimentary Pharmacology and Therapeutics, July 29, 2015  Clinical Article
2Detection of small bowel mucosal healing and deep remission in patients with known small bowel Crohn’s disease using biomarkers, capsule endoscopy, and imaging The American Journal of Gastroenterology, July 29, 2015  Clinical Article
3Effects of long-term entecavir treatment on the incidence of hepatocellular carcinoma in chronic hepatitis B patientsHepatology International, July 29, 2015  Clinical Article
4Tailored therapy for the refractory GERD patients by combined multichannel intraluminal impedance-pH monitoringJournal of Gastroenterology and Hepatology, July 29, 2015  Clinical Article
5Effect of metformin treatment on circulating osteoprotegerin in patients with nonalcoholic fatty liver diseaseHepatology International, July 29, 2015  Clinical Article
6Differential accumulation and function of proinflammatory 6-sulfo LacNAc dendritic cells in lymph node and colon of Crohn’s versus ulcerative colitis patientsJournal of Leukocyte Biology, July 29, 2015  Clinical Article
7Aflibercept: a review in metastatic colorectal cancerDrugs, July 29, 2015  Review Article
8Early life predictive markers of liver disease outcome in an international, multi-center cohort of children with Alagille syndromeLiver International, July 29, 2015  Clinical Article
9Linked PNPLA3 polymorphisms confer susceptibility to nonalcoholic steatohepatitis and decreased viral load in chronic hepatitis BWorld Journal of Gastroenterology, July 29, 2015  Full Text  Clinical Article
10Optimizing patient treatment decisions in an era of rapid technological advances: the case of hepatitis C treatmentHealth Care Management Science, July 29, 2015  Clinical Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Study finds rerouting bile acids may offer simpler alternative to gastric bypass surgeryVanderbilt University Medical Center Research News, July 29, 2015
2FDA approves non-surgical temporary balloon device to treat obesityFDA Press Announcements, July 29, 2015
3Soybean oil causes more obesity than coconut oil and fructoseThe University of California, Riverside Health News, July 28, 2015
4Study shows targeting bacteria causing ulcers may prevent stomach cancerMcMaster University Faculty of Health Sciences News, July 28, 2015
5Launch of a nationwide hepatitis C elimination program - Georgia, April 2015Morbidity and Mortality Weekly Report, July 28, 2015
6Viral hepatitis surveillance - India, 2011-2013Morbidity and Mortality Weekly Report, July 28, 2015
7Gene variants increase colorectal cancer risk, study showsUW Medicine, July 28, 2015
8New material opens possibilities for super-long-acting pillsMassachusetts Institute of Technology Research News, July 28, 2015
9Study: Many consumers do not wash their hands after cracking eggs, increasing food poisoning riskRTI International News, July 27, 2015
10New 'chemotherapy booster' could treat lung and pancreatic cancerInstitute of Cancer Research, July 27, 2015

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SCCA-IgM predicts survival in HCC patients

As reported in the Journal of Gastroenterology & Hepatology, SCCA-IgM levels are elevated in patients with hepatocellular carcinoma (HCC) compared to patients with cirrhosis and healthy controls. Not only does the SCCA-IgM level predict overall and progression-free survival in HCC patients, but the sensitivity of SCCA-IgM in patients with HCC was 2-fold greater than AFP. A decline in SCCA-IgM levels was shown to be associated with response to treatment.

Risk factors for CHC-related death identified

As reported in the World Journal of Gastroenterology, the following risk factors for chronic hepatitis C (CHC)-related deaths have been identified (n=8250 CHC patients; n=144 CHC-related deaths): α-IFN therapy (AOR=0.53); liver cirrhosis (AOR=2.89); hepatocellular carcinoma versus CHC (AOR=8.82); hypertension (AOR=1.76); alcohol consumption (AOR=1.73); and HBsAg positivity (AOR=22.28).

KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

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Clinical Pearls

Clinical Pearl from Smartest DocPlasma HDL cholesterol and triglyceride levels are associated with colorectal adenoma risk.

Clinical Pearl from Smartest DocGERD, but not Barrett's esophagus, increases the risk of poor sleep quality.

Clinical Pearl from Smartest DocGastroesophageal reflux disease is determined by an abnormal upper endoscopy or 24-hour pH-impedance monitoring.

Clinical Articles in Gastroenterology

MDLinx Gastroenterology and HepatologyNews

Search today's latest gastroenterology news, updated daily from over 2,000 peer-reviewed journals, at MDLinx. Stay current with up-to-the-minute digestive system information and hepatology related clinical research covering all aspects of the gastrointestinal (GI) tract. Our diligent team of MDLinx physician editors rigorously research a wide range of gastroenterology medical journals dedicated to biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition and diagnostic imaging. They then summarize and rank the articles by clinical impact to provide the most valuable literature to make sure any gastroenterologist, and all members of their healthcare team, can stay current with the latest in gastrointestinal clinical research and hepatobiliary medicine.