The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists. Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in Gastroenterology. In addition to general news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.
1 Effect of adjuvant capecitabine or fluorouracil, with or without oxaliplatin, on survival outcomes in stage III colon cancer and the effect of oxaliplatin on post-relapse survival: A pooled analysis of individual patient data from four randomised controlled trials The Lancet Oncology, November 25, 2014 Clinical Article
2 Prognosis after first-time myocardial infarction in patients with inflammatory bowel disease according to disease activity Circulation: Cardiovascular Quality and Outcomes, November 25, 2014 Clinical Article
3 Different antibiotic susceptibility between antrum and corpus of the stomach, a possible reason for treatment failure of Helicobacter pylori infection Full Text World Journal of Gastroenterology, November 25, 2014 Clinical Article
4 Acute hepatitis C infection in HIV-negative men who have sex with men Journal of Viral Hepatitis, November 25, 2014 Clinical Article
5 Two-week treatment with proton pump inhibitor is sufficient for healing post endoscopic submucosal dissection ulcers Full Text World Journal of Gastroenterology, November 25, 2014 Clinical Article
6 Association between antiviral treatment and extrahepatic outcomes in patients with hepatitis C virus infection Gut, November 25, 2014 Clinical Article
7 Docetaxel plus oxaliplatin with or without fluorouracil or capecitabine in metastatic or locally recurrent gastric cancer: A randomized phase II study Annals of Oncology, November 25, 2014 Clinical Article
8 Long-term risk of colorectal cancer in individuals with serrated polyps Gut, November 25, 2014 Clinical Article
9 miR-34a-5p suppresses colorectal cancer metastasis and predicts recurrence in patients with stage II/III colorectal cancer Oncogene, November 25, 2014 Clinical Article
10 Feasibility and safety of sorafenib treatment in hepatocellular carcinoma patients with spontaneous rupture Full Text World Journal of Gastroenterology, November 25, 2014 Clinical Article
11 Initial surgical management of ulcerative colitis in the biologic era Diseases of the Colon and Rectum, November 25, 2014 Clinical Article
12 Clinical and economic impact of drug eluting beads in transarterial chemoembolization for hepatocellular carcinoma Journal of Clinical Pharmacy and Therapeutics, November 25, 2014 Clinical Article
13 A systematic review and meta-analysis of somatic and germline DNA sequence biomarkers of esophageal cancer survival, therapy response and stage Annals of Oncology, November 25, 2014 Evidence Based Medicine Review Article
14 Endoscopic ultrasonography-guided endoscopic treatment of pancreatic pseudocysts and walled-off necrosis: New technical developments Full Text World Journal of Gastroenterology, November 25, 2014 Review Article
15 Management of malignant colon polyps: Current status and controversies Full Text World Journal of Gastroenterology, November 25, 2014 Review Article
16 Development of risk scoring system for stratifying population for hepatocellular-carcinoma screening Hepatology, November 25, 2014 Clinical Article
17 HBsAg genetic elements critical for immune escape correlate with HBV-reactivation upon immunosuppression Hepatology, November 25, 2014 Clinical Article
18 TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway Oncogene, November 25, 2014 Clinical Article
19 Ribavirin induced hemolysis: A novel mechanism of action against chronic hepatitis C virus infection Full Text World Journal of Gastroenterology, November 25, 2014 Clinical Article
20 Potent antiviral therapy improves survival in acute on chronic liver failure due to hepatitis B virus reactivation Full Text World Journal of Gastroenterology, November 25, 2014 Review Article
As reported in the Journal of Crohn’s & Colitis, treatment of corticosteroid-refractory ulcerative colitis patients with 3 doses of infliximab (n=113) resulted in short- (3 months) and long-term (12 months) colectomy rates of 18.6% and 25.6%, respectively. The RR of colectomy in patients with an elevated CRP and severe endoscopic lesions was 2.15 and 5.13, respectively.
As reported in the World Journal of Gastroenterology, the following risk factors for chronic hepatitis C (CHC)-related deaths have been identified (n=8250 CHC patients; n=144 CHC-related deaths): α-IFN therapy (AOR=0.53); liver cirrhosis (AOR=2.89); hepatocellular carcinoma versus CHC (AOR=8.82); hypertension (AOR=1.76); alcohol consumption (AOR=1.73); and HBsAg positivity (AOR=22.28).
As reported in the International Journal of Cancer, there is an 8% reduction in CRC risk with each 300 mg/d increase in calcium intake based on 15 studies involving 12305 patients who took 250-1900 mg of calcium/day over a 3.3-16 year follow-up period. The beneficial effect extended beyond 1000 mg/d.