Gastroenterology News Articles

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The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists. Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in Gastroenterology. In addition to general news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.

Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 Rilotumumab in combination with epirubicin, cisplatin, and capecitabine as first-line treatment for gastric or oesophagogastric junction adenocarcinoma: an open-label, dose de-escalation phase 1b study and a double-blind, randomised phase 2 study The Lancet Oncology, July 29, 2014    Clinical Article

2 A phase II, open-label, multicenter study to evaluate the antitumor efficacy of CO-1.01 as second-line therapy for gemcitabine-refractory patients with stage IV pancreatic adenocarcinoma and negative tumor hENT1 expression Pancreatology, July 29, 2014    Clinical Article

3 Adalimumab monotherapy versus combination therapy with immunomodulators in patients with Crohn's disease: A systematic review and meta-analysis Journal of Crohn's and Colitis, July 29, 2014    Evidence Based Medicine    Review Article

4 The clinical course of a gastrointestinal stromal tumor (GIST) diagnosed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) Digestive Endoscopy, July 29, 2014    Clinical Article

5 Clinical staging of patients with early esophageal adenocarcinoma: Does FDG-PET/CT have a role Journal of Thoracic Oncology, July 29, 2014    Clinical Article

6 Continuous versus intermittent chemotherapy strategies in metastatic colorectal cancer: a systematic review and meta-analysis Annals of Oncology, July 29, 2014    Evidence Based Medicine    Review Article

7 Optimal approach to the management of intrathoracic esophageal leak following esophagectomy: A systematic review. The American Journal of Surgery, July 29, 2014    Evidence Based Medicine    Review Article

8 Effects of antidepressants in patients with functional esophageal disorders or gastroesophageal reflux disease: a systematic review Clinical Gastroenterology and Hepatology , July 29, 2014    Evidence Based Medicine    Review Article

9 Critical items for assessing risk of lung and colorectal cancer in primary care: a Delphi study British Journal of General Practice, July 29, 2014    Evidence Based Medicine    Review Article

10 Clinical outcomes of hepatitis B virus co-infection in a United States cohort of hepatitis C virus-infected patients Hepatology, July 29, 2014    Clinical Article

11 Accuracy of magnetic resonance imaging in diagnosis of liver iron overload: a systematic review and meta-analysis Clinical Gastroenterology and Hepatology , July 29, 2014    Evidence Based Medicine    Review Article

12 Olmesartan, other antihypertensives, and chronic diarrhea among patients undergoing endoscopic procedures: a case-control study Mayo Clinic Proceedings, July 29, 2014    Evidence Based Medicine    Clinical Article

13 Fecal level of calprotectin identifies histologic inflammation in patients with ulcerative colitis in clinical and endoscopic remission Clinical Gastroenterology and Hepatology , July 29, 2014    Clinical Article

14 The association of metabolic syndrome and its factors with gallstone disease Full Text BMC Family Practice, July 29, 2014    Clinical Article

15 The impact of oxaliplatin-based chemotherapy for colorectal cancer on the autonomous nervous system European Journal of Neurology, July 29, 2014    Clinical Article

16 Comparative effectiveness research of chronic hepatitis B and C cohort study (CHES): improving data collection and cohort identification Digestive Diseases and Sciences, July 29, 2014    Clinical Article

17 Predictors of urgent findings on abdominopelvic CT in patients with Crohn’s disease presenting to the emergency department Digestive Diseases and Sciences, July 29, 2014    Clinical Article

18 Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: the COSMOS randomised study The Lancet, July 29, 2014    Evidence Based Medicine    Clinical Article

19 Induction therapy does not improve survival for clinical stage T2N0 esophageal cancer Journal of Thoracic Oncology, July 29, 2014    Clinical Article

20 Perfusion parameters of dynamic contrast-enhanced magnetic resonance imaging predict outcomes of hepatocellular carcinoma receiving radiotherapy with or without thalidomide Hepatology International, July 29, 2014    Clinical Article

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Highlights in Gastroenterology

SCCA-IgM predicts survival in HCC patients

As reported in the Journal of Gastroenterology & Hepatology, SCCA-IgM levels are elevated in patients with hepatocellular carcinoma (HCC) compared to patients with cirrhosis and healthy controls. Not only does the SCCA-IgM level predict overall and progression-free survival in HCC patients, but the sensitivity of SCCA-IgM in patients with HCC was 2-fold greater than AFP. A decline in SCCA-IgM levels was shown to be associated with response to treatment.

Calcium reduces CRC risk

As reported in the International Journal of Cancer, there is an 8% reduction in CRC risk with each 300 mg/d increase in calcium intake based on 15 studies involving 12305 patients who took 250-1900 mg of calcium/day over a 3.3-16 year follow-up period. The beneficial effect extended beyond 1000 mg/d.

Risk factors for intra-abdominal abscesses in Crohn’s disease

As reported in Digestion, uncontrolled CRP at week 14 of therapy with infliximab (OR=1.36) and early loss of response to infliximab (OR=5.36) are independent risk factors for intra-abdominal abscesses in patients with Crohn’s disease.

Other Topics in Gastroenterology

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