The Latest Clinical Articles in Gastroenterology & GastroIntestinal

1Obesity in inflammatory bowel disease Digestive Diseases and Sciences, April 01, 2015  Review Article
2Early life body fatness and risk of colorectal cancer in U.S. women and men—results from two large cohort studiesCancer Epidemiology, Biomarkers & Prevention, April 01, 2015  Clinical Article
3Association of cholesterol with risk of pancreatic cancer: A meta-analysisWorld Journal of Gastroenterology, April 01, 2015  Full Text  Clinical Article
4Impact of metabolic syndrome on the hospitalization rate of Crohn's disease patients seen at a tertiary care center: A retrospective cohort studyDigestion, April 01, 2015  Clinical Article
5Open-label phase 1b study of FOLFIRI plus cetuximab plus IMO-2055 in patients with colorectal cancer who have progressed following chemotherapy for advanced or metastatic diseaseCancer Chemotherapy and Pharmacology, April 01, 2015  Clinical Article
6Helicobacter pylori infection in psoriasis: Results of a clinical study and review of the literatureInternational Journal of Dermatology, April 01, 2015  Clinical Article  Review Article
7Brain metastasis from colorectal carcinomaIrish Journal of Medical Science, April 01, 2015  Clinical Article
8Long-term efficacy of biofeedback therapy in patients with dyssynergic defecation: Results of a median 44 months follow-upNeurogastroenterology & Motility, April 01, 2015  Clinical Article
9Phase II study of gemcitabine and S-1 combination chemotherapy in patients with metastatic biliary tract cancerCancer Chemotherapy and Pharmacology, April 01, 2015  Clinical Article
10Quantitative assessment of small bowel motility in patients with Crohn's disease using dynamic MRINeurogastroenterology & Motility, April 01, 2015  Clinical Article
1UCLA researchers develop more accurate tool to predict whether liver cancer will recur in transplant patientsUCLA Health System, April 01, 2015
2Eat your veggies to lower colon cancer riskBaylor Health Care System, April 01, 2015
3University Hospitals Leuven successfully apply innovative technique for liver transplantsKU Leuven News, April 01, 2015
4Protein may improve liver regenerationUC Davis Health System, April 01, 2015
5Genetic background determines whether aspirin/NSAIDS will reduce colorectal cancer riskMassachusetts General Hospital, March 31, 2015
6Drinking raw milk dramatically increases risk for foodborne illness, analysis findsJohns Hopkins Bloomberg School of Public Health, March 31, 2015
7ASCP, CAP, AMP, and ASCO issue draft colorectal cancer molecular marker testing guideline and announce opening of public comment periodAmerican Society of Clinical Oncology (ASCO) News, March 31, 2015
8FDA warns against combination of hepatitis C treatment and antiarrhythmic drugAmerican College of Cardiology News, March 31, 2015
9MAIT cell alterations involved in obesity and T2 diabetesCentre National de la Recherche Scientifique News, March 31, 2015
10Researchers reverse type 2 diabetes and fatty liver diseaseUniversity of Copenhagen Faculty of Health and Medical Sciences News, March 30, 2015

Show Me:

Infliximab is effective in corticosteroid-refractory ulcerative colitis

As reported in the Journal of Crohn’s & Colitis, treatment of corticosteroid-refractory ulcerative colitis patients with 3 doses of infliximab (n=113) resulted in short- (3 months) and long-term (12 months) colectomy rates of 18.6% and 25.6%, respectively. The RR of colectomy in patients with an elevated CRP and severe endoscopic lesions was 2.15 and 5.13, respectively.

KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

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