The Latest Clinical Articles in Gastroenterology & GastroIntestinal

1Effect of immunosuppressive therapies for the treatment of inflammatory bowel disease on response to routine vaccinations: a meta-analysisDigestive Diseases and Sciences, March 31, 2015  Clinical Article
2Improved pharmacodynamics and pharmacokinetics after I.V. application of peginterferon alfa-2a in hepatitis C null-respondersLiver International, March 31, 2015  Clinical Article
3Inpatient burden of childhood functional GI disorders in the USA: an analysis of national trends in the USA from 1997 to 2009Neurogastroenterology & Motility, March 31, 2015  Clinical Article
4Hormonal and reproductive factors and risk of esophageal cancer in women: a meta-analysisDiseases of the Esophagus, March 31, 2015  Evidence Based Medicine
5Tenofovir disoproxil fumarate has a substantial efficacy against multidrug resistant strains of hepatitis B virusLiver International, March 31, 2015  Clinical Article
6Helicobacter pylori negative gastric cancer: characteristics and endoscopic findingsDigestive Endoscopy, March 31, 2015  Review Article
7Psychoactive medications increase the risk of falls and fall-related injuries in hospitalized patients with cirrhosisClinical Gastroenterology and Hepatology , March 31, 2015  Clinical Article
8Advantages of fecal lactoferrin measurement during granulocyte and monocyte adsorptive apheresis therapy in ulcerative colitisDigestion, March 31, 2015  Clinical Article
9Status of competency-based medical education in endoscopy training: A nationwide survey of US ACGME-Accredited Gastroenterology Training ProgramsThe American Journal of Gastroenterology, March 31, 2015  Clinical Article
10Breath methane excretion is not an accurate marker of colonic methane production in irritable bowel syndromeThe American Journal of Gastroenterology, March 31, 2015  Clinical Article
1Genetic background determines whether aspirin/NSAIDS will reduce colorectal cancer riskMassachusetts General Hospital, March 31, 2015
2Drinking raw milk dramatically increases risk for foodborne illness, analysis findsJohns Hopkins Bloomberg School of Public Health, March 31, 2015
3ASCP, CAP, AMP, and ASCO issue draft colorectal cancer molecular marker testing guideline and announce opening of public comment periodAmerican Society of Clinical Oncology (ASCO) News, March 31, 2015
4FDA warns against combination of hepatitis C treatment and antiarrhythmic drugAmerican College of Cardiology News, March 31, 2015
5MAIT cell alterations involved in obesity and T2 diabetesCentre National de la Recherche Scientifique News, March 31, 2015
6Researchers reverse type 2 diabetes and fatty liver diseaseUniversity of Copenhagen Faculty of Health and Medical Sciences News, March 30, 2015
7How our DNA may prevent bowel cancerUniversity of Melbourne News, March 30, 2015
8American College of Physicians joins HHS in accelerating alternative payment methods through ‘Health Care Payment Learning and Action Network’ American College of Physicians News, March 26, 2015
9Exciting data presented at the 4th Gut Microbiota For Health SummitAmerican Gastroenterological Association News, March 23, 2015
10NCCS pioneers new drug regimen which reduces toxicities for renal cancer patientsNational Cancer Centre Singapore News, March 23, 2015

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Predictors of sustained binge drinking

As reported in Alcoholism: Clinical & Experimental Research, sustained binge drinkers have an earlier onset, drink monthly in secondary school, binged in their 20s, exhibit impulsivity and novelty-seeking, and have depressive symptoms during adolescence compared to those who stop binge drinking.

KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

Risk factors for CHC-related death identified

As reported in the World Journal of Gastroenterology, the following risk factors for chronic hepatitis C (CHC)-related deaths have been identified (n=8250 CHC patients; n=144 CHC-related deaths): α-IFN therapy (AOR=0.53); liver cirrhosis (AOR=2.89); hepatocellular carcinoma versus CHC (AOR=8.82); hypertension (AOR=1.76); alcohol consumption (AOR=1.73); and HBsAg positivity (AOR=22.28).

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