We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Population pharmacokinetics of infliximab in patients with inflammatory bowel disease: Potential implications for dosing in clinical practiceAlimentary Pharmacology and Therapeutics, July 03, 2015  Clinical Article
2Association of baseline vitamin D levels with clinical parameters and treatment outcomes in chronic hepatitis BJournal of Hepatology, July 03, 2015  Clinical Article
3Dietary polyamine intake and colorectal cancer risk in postmenopausal womenAmerican Journal of Clinical Nutrition, July 03, 2015  Clinical Article
4Cost-effectiveness of strategies for testing current hepatitis C virus infectionHepatology, July 03, 2015  Clinical Article
5Effects of preceding endoscopic mucosal resection on the efficacy and safety of radiofrequency ablation for treatment of Barrett's esophagus: results from the United States Radiofrequency Ablation RegistryDiseases of the Esophagus, July 03, 2015  Clinical Article
6Phase II study of trastuzumab in combination with S-1 and cisplatin in the first-line treatment of human epidermal growth factor receptor HER2-positive advanced gastric cancerCancer Chemotherapy and Pharmacology, July 03, 2015  Clinical Article
7Trastuzumab in combination with docetaxel/cisplatin/S-1 (DCS) for patients with HER2-positive metastatic gastric cancer: Feasibility and preliminary efficacyCancer Chemotherapy and Pharmacology, July 03, 2015  Clinical Article
8Immunogenicity of an investigational hepatitis B vaccine with a toll-like receptor 9 agonist adjuvant (HBsAg-1018) compared with a licensed hepatitis B vaccine in subpopulations of healthy adults 18-70 years of ageVaccine , July 03, 2015  Clinical Article
9Combined Analysis of the Prevalence of drug Resistant HBV in antiviral therapy Experienced patients in Europe (CAPRE)The Journal of Infectious Diseases, July 03, 2015  Clinical Article
10Protease inhibitors to treat hepatitis C in the Swiss HIV Cohort Study: High efficacy but low treatment uptakeHIV Medicine, July 03, 2015  Clinical Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Anxiety increases the risk of gastrointestinal infection and long-term complicationsFlanders Institute for Biotechnology (VIB) News, July 03, 2015
2World GI 2015: Patients with lowest BMI have shortest survival in pooled analysis of bevacizumab in metastatic colorectal cancerEuropean Society for Medical Oncology News, July 03, 2015
3World GI 2015: SENRI trial opens window to evaluate NK1 antagonists for emesis prevention in oxaliplatin chemotherapyEuropean Society for Medical Oncology News, July 03, 2015
4Pinaverium shows promising results for treatment of irritable bowel syndromeAmerican Gastroenterological Association News, July 02, 2015
5Spouses & relatives of celiac disease patients at risk for autoimmune diseasesAmerican Gastroenterological Association News, July 02, 2015
6National study finds life-threatening barriers in access to breakthrough drugsThe Miriam Hospital, July 02, 2015
7Public health surveillance system may seriously underestimate cases of acute hepatitis C infectionMassachusetts General Hospital, July 02, 2015
8Study finds no association between amylase genes, obesityBroad Institute News, July 02, 2015
9Antibiotic treatments could affect pediatric development, animal study suggestsThe Jackson Laboratory News, July 02, 2015
10New hepatitis C treatment needs no antiviral boostJohns Hopkins Medicine, July 02, 2015

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KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

Increased MMP-9 expression associated with poor prognosis in CRC

As reported in the World Journal of Surgical Oncology, the expression of MMP-9 in colon cancer tissues was increased compared to distal normal mucosa (69.1% vs. 2.9%). Increased MMP-9 expression was associated with lymph node metastasis, Duke stage, and decreased survival.

Calcium reduces CRC risk

As reported in the International Journal of Cancer, there is an 8% reduction in CRC risk with each 300 mg/d increase in calcium intake based on 15 studies involving 12305 patients who took 250-1900 mg of calcium/day over a 3.3-16 year follow-up period. The beneficial effect extended beyond 1000 mg/d.

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Clinical Pearls

Clinical Pearl from Smartest DocNeoadjuvant FOLFIRINOX allows for R0 resection in 40% of borderline resectable or unresectable pancreatic cancer.

Clinical Pearl from Smartest DocPatients with chronic hepatitis C experience pruritus more than those without.

Clinical Pearl from Smartest DocIn patients with short-segment Barrett's esophagus, neoplastic progression is associated with impairment of chemical clearance.

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