The Latest Clinical Articles in Gastroenterology & GastroIntestinal

1Applying pharmacokinetics to optimise dosing of anti-TNF biologics in acute severe ulcerative colitisAlimentary Pharmacology and Therapeutics, March 26, 2015  Clinical Article  Review Article
2Emergency department burden of constipation in the United States from 2006 to 2011The American Journal of Gastroenterology, March 26, 2015  Clinical Article
3Hepcidin/ferroportin expression levels involve efficacy of pegylated-interferon plus ribavirin in hepatitis C virus-infected liverWorld Journal of Gastroenterology, March 26, 2015  Full Text  Clinical Article
4Treating gastritis, peptic ulcer disease, and dyspepsia in the emergency department: the feasibility and patient-reported outcomes of testing and treating for Helicobacter pylori infectionAnnals of Emergency Medicine, March 26, 2015  Clinical Article
5Efficacy of bevacizumab and chemotherapy in the first-line treatment of metastatic colorectal cancer: broadening KRAS-focused clinical viewBMC Gastroenterology, March 26, 2015  Full Text  Clinical Article
6Low muscle mass and sarcopenia: Common and predictive of osteopenia in inflammatory bowel diseaseAlimentary Pharmacology and Therapeutics, March 26, 2015  Clinical Article
7Public health impact of achieving 80% colorectal cancer screening rates in the United States by 2018Cancer, March 26, 2015  Clinical Article
8Effects of preoperative and postoperative enteral nutrition on postoperative nutritional status and immune function of gastric cancer patientsThe Turkish Journal of Gastroenterology, March 26, 2015  Full Text  Clinical Article
9The science, evidence and practice of dietary interventions in irritable bowel syndrome.Clinical Gastroenterology and Hepatology , March 26, 2015  Clinical Article
10The long-term mortality of spontaneous bacterial peritonitis in cirrhotic patients: A 3-year nationwide cohort studyThe Turkish Journal of Gastroenterology, March 26, 2015  Full Text  Clinical Article
1American College of Physicians joins HHS in accelerating alternative payment methods through ‘Health Care Payment Learning and Action Network’ American College of Physicians News, March 26, 2015
2Exciting data presented at the 4th Gut Microbiota For Health SummitAmerican Gastroenterological Association News, March 23, 2015
3NCCS pioneers new drug regimen which reduces toxicities for renal cancer patientsNational Cancer Centre Singapore News, March 23, 2015
4Tumour determination in bowel cancer: Blood test replaces surgeryMedical University of Vienna, March 19, 2015
5A single-cell breakthroughUNC Health Care System, March 19, 2015
6Rebooting cell programming can reverse liver failure, says Children's Hospital/Pitt studyUPMC, March 19, 2015
7Does aspirin prevent colorectal cancer? Depends on your DNAFred Hutchinson Cancer Research Center News, March 19, 2015
8Potential drug target found to prevent bowel cancer spreadMonash University News, March 19, 2015
9Penn vet team points to new colon cancer culpritUniversity of Pennsylvania News, March 18, 2015
10FDA approves Cholbam to treat rare bile acid synthesis disordersFDA Press Announcements, March 18, 2015

Show Me:

Elevated ?-GT predicts HCC in hepatitis C patients with sustained response

As reported in the Journal of Hepatology, an elevated baseline ɣ-GT level is the strongest predictor of developing HCC in non-cirrhotic patients with hepatitis C and a sustained virologic response (HR = 6.44), followed by age (HR = 3.68).

Risk factors for CHC-related death identified

As reported in the World Journal of Gastroenterology, the following risk factors for chronic hepatitis C (CHC)-related deaths have been identified (n=8250 CHC patients; n=144 CHC-related deaths): α-IFN therapy (AOR=0.53); liver cirrhosis (AOR=2.89); hepatocellular carcinoma versus CHC (AOR=8.82); hypertension (AOR=1.76); alcohol consumption (AOR=1.73); and HBsAg positivity (AOR=22.28).

KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

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Clinical Pearl from Smartest DocNarrow band imaging may be more effective for detecting colorectal adenoma and polyps than high-definition white-light colonoscopy.

Clinical Pearl from Smartest DocEverolimus did not improve overall survival in patients with advanced hepatocellular carcinoma for whom sorafenib failed.

Clinical Pearl from Smartest DocMortality rates are similar between laparoscopic and open resection surgeries for transverse colon cancer.

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