We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Prevalence of antibodies against JC virus in serum of patients with refractory Crohn's disease and effects of natalizumab therapyClinical Gastroenterology and Hepatology , May 27, 2015  Clinical Article
2Omega-3 polyunsaturated fatty acids in treating non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trialClinical Nutrition, May 27, 2015  Clinical Article
3Phase II study of docetaxel, oxaliplatin, and S-1 therapy in patients with metastatic gastric cancerGastric Cancer, May 27, 2015  Clinical Article
4Serum vitamin D levels in a cohort of adult and pediatric patients with eosinophilic esophagitisAnnals of Allergy, Asthma, and Immunology, May 27, 2015  Clinical Article
5Comparative risk of gastrointestinal bleeding with dabigatran, rivaroxaban, and warfarin: population based cohort studyBMJ, May 27, 2015  Clinical Article  Evidence Based Medicine
6Phase I/II study of temsirolimus for patients with unresectable Hepatocellular Carcinoma (HCC)- a correlative study to explore potential biomarkers for responseBMC Cancer, May 27, 2015  Full Text  Clinical Article
7Prevalence of chronic metoclopramide use and associated diagnoses in the US pediatric populationPediatric Drugs, May 27, 2015  Clinical Article
8Obesity increases risk of ischemic stroke in young adultsStroke, May 27, 2015  Clinical Article
9Serum vitamin D level is associated with disease severity and response to ursodeoxycholic acid in primary biliary cirrhosisAlimentary Pharmacology and Therapeutics, May 27, 2015  Review Article
10Holotranscobalamin levels in children with Helicobacter pylori infectionHelicobacter, May 27, 2015  Clinical Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Research News Tpl2 enzyme may be target for treating autoimmune diseasesUniversity of Georgia Research News, May 27, 2015
2New demonstration project links colorectal cancer screening to discussion and testing for hepatitis CAmerican College of Gastroenterology News, May 27, 2015
3Researchers discover tumor molecule that causes spread of pancreatic cancerFred Hutchinson Cancer Research Center News, May 26, 2015
4In study, skipping meals is linked to abdominal weight gainOhio State University News, May 21, 2015
5Helping doctors predict what's next for patients diagnosed with Hepatitis CUniversity of Michigan Health System, May 21, 2015
6Study reveals intestinal bacteria succession during recovery from cholera in BangladeshMassachusetts General Hospital, May 21, 2015
7Liver-sparing operation associated with higher survival rates in cancer patientsAmerican College of Surgeons News, May 20, 2015
8University Hospitals Seidman Cancer Center study finds non-invasive colon cancer screening may be promising for African AmericansUniversity Hospitals Case Medical Center News, May 20, 2015
9New targeted treatment IMMU-130 shows promise in patients with metastatic colon cancerFox Chase Cancer Center News, May 20, 2015
10Expert alert – precision medicine and obesityMayo Clinic, May 20, 2015

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Increased MMP-9 expression associated with poor prognosis in CRC

As reported in the World Journal of Surgical Oncology, the expression of MMP-9 in colon cancer tissues was increased compared to distal normal mucosa (69.1% vs. 2.9%). Increased MMP-9 expression was associated with lymph node metastasis, Duke stage, and decreased survival.

KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

Risk factors for CHC-related death identified

As reported in the World Journal of Gastroenterology, the following risk factors for chronic hepatitis C (CHC)-related deaths have been identified (n=8250 CHC patients; n=144 CHC-related deaths): α-IFN therapy (AOR=0.53); liver cirrhosis (AOR=2.89); hepatocellular carcinoma versus CHC (AOR=8.82); hypertension (AOR=1.76); alcohol consumption (AOR=1.73); and HBsAg positivity (AOR=22.28).

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Clinical Pearls

Clinical Pearl from Smartest DocPatients with Crohn’s disease have a higher prevalence of vitamin A deficiency.

Clinical Pearl from Smartest DocThe board game Kaledo may be used as an effective tool in childhood and adolescence obesity prevention programs.

Clinical Pearl from Smartest DocIDO inhibition decreases the expression of IL-4 in gastric biopsy cultures.

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