Gastroenterology News Articles

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The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists. Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in Gastroenterology. In addition to general news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.

Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 A prospective 12-week mucosal healing assessment of small bowel Crohn’s disease as detected by capsule endoscopy European Journal of Gastroenterology & Hepatology, October 17, 2014    Clinical Article

2 Adjuvant capecitabine plus oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): 5-year follow-up of an open-label, randomised phase 3 trial The Lancet Oncology, October 17, 2014    Clinical Article

3 A randomized, open-label clinical study of combined pegylated interferon alfa-2a (40KD) and entecavir treatment for hepatitis B E antigen-positive chronic hepatitis B Clinical Infectious Diseases, October 17, 2014    Clinical Article

4 Symptom profile in partial responders to a proton pump inhibitor compared with treatment-naive patients with gastroesophageal reflux disease: a post hoc analysis of two study populations Full Text BMC Gastroenterology, October 17, 2014    Clinical Article

5 Risk of Parkinson's disease following severe constipation: A nationwide population-based cohort study Parkinsonism & Related Disorders, October 17, 2014    Clinical Article

6 Promotion and provision of colorectal cancer screening: a comparison of colorectal cancer control program grantees and nongrantees, 2011–2012 Full Text Preventing Chronic Disease, October 17, 2014    Review Article

7 A randomized controlled trial comparing a low-residue diet versus clear liquids for colonoscopy preparation: impact on tolerance, procedure time, and adenoma detection rate Journal of Clinical Gastroenterology, October 17, 2014    Clinical Article

8 Increased humoral immunity in the jejunum of diarrhoea-predominant irritable bowel syndrome associated with clinical manifestations Gut, October 17, 2014    Clinical Article

9 Current practices of screening for incident hepatitis C virus (HCV) infection among HIV-infected, HCV-uninfected individuals in primary care Clinical Infectious Diseases, October 17, 2014    Clinical Article

10 MELD-Na: effective in predicting rebleeding in cirrhosis after cessation of esophageal variceal hemorrhage by endoscopic therapy Journal of Clinical Gastroenterology, October 17, 2014    Clinical Article

11 Impact of common risk factors of fibrosis progression in chronic hepatitis C Gut, October 17, 2014    Clinical Article

12 New approaches to gastric cancer staging: Beyond endoscopic ultrasound, computed tomography and positron emission tomography Full Text World Journal of Gastroenterology, October 17, 2014    Review Article

13 Electrocautery-induced localized colonic injury elicits increased levels of pro-inflammatory cytokines in small bowel and decreases jejunal alanine absorption Cytokine, October 17, 2014    Clinical Article

14 Ramucirumab: Successfully targeting angiogenesis in gastric cancer Clinical Cancer Research, October 17, 2014    Clinical Article

15 Laparoscopic versus open repair of recto-bladderneck and recto-prostatic anorectal malformations: A systematic review and meta-analysis Pediatric Surgery International, October 17, 2014    Review Article    Clinical Guideline

16 Gastric cancer arising from the remnant stomach after distal gastrectomy: A review Full Text World Journal of Gastroenterology, October 17, 2014    Review Article

17 Care practices and traditional beliefs related to neonatal jaundice in northern Vietnam: a population-based, cross-sectional descriptive study Full Text BMC Pediatrics, October 17, 2014    Clinical Article

18 Prognostic significance of radical surgical treatment for gastric cancer patients with synchronous liver metastases Medical Oncology, October 17, 2014    Clinical Article

19 Calprotectin in bile: a disease severity marker in patients with primary sclerosing cholangitis Journal of Clinical Gastroenterology, October 17, 2014    Clinical Article

20 Usefulness of the neutrophil/lymphocyte ratio measured preoperatively as a predictor of peritoneal metastasis in patients with advanced gastric cancer Surgery Today, October 17, 2014    Review Article
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Highlights in Gastroenterology

KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

Infliximab is effective in corticosteroid-refractory ulcerative colitis

As reported in the Journal of Crohn’s & Colitis, treatment of corticosteroid-refractory ulcerative colitis patients with 3 doses of infliximab (n=113) resulted in short- (3 months) and long-term (12 months) colectomy rates of 18.6% and 25.6%, respectively. The RR of colectomy in patients with an elevated CRP and severe endoscopic lesions was 2.15 and 5.13, respectively.

Increased MMP-9 expression associated with poor prognosis in CRC

As reported in the World Journal of Surgical Oncology, the expression of MMP-9 in colon cancer tissues was increased compared to distal normal mucosa (69.1% vs. 2.9%). Increased MMP-9 expression was associated with lymph node metastasis, Duke stage, and decreased survival.

Other Topics in Gastroenterology

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