The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists. Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in Gastroenterology. In addition to general news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.
1 Antiviral therapy improves post-hepatectomy survival in patients with hepatitis B virus-related hepatocellular carcinoma: A prospective-retrospective study Alimentary Pharmacology and Therapeutics, November 24, 2014 Clinical Article
2 Pharmacological intervention based on fecal calprotectin levels in patients with ulcerative colitis at high risk of a relapse: A prospective, randomized, controlled study United European Gastroenterology Journal, November 24, 2014 Clinical Article
3 Validation of the Lewis score for the evaluation of small-bowel Crohn's disease activity Endoscopy, November 24, 2014 Clinical Article
4 Dose-dependent effects of lesogaberan on reflux measures in patients with refractory gastroesophageal reflux disease: A randomized, placebo-controlled study Full Text BMC Gastroenterology, November 24, 2014 Clinical Article
5 Fish consumption and risk of non–gallstone-related acute pancreatitis: a prospective cohort study American Journal of Clinical Nutrition, November 24, 2014 Clinical Article
6 Intensive follow-up strategies improve outcomes in non-metastatic colorectal cancer patients after curative surgery. A systematic review and meta-analysis Annals of Oncology, November 24, 2014 Review Article
7 Combination therapy with sorafenib and radiofrequency ablation for BCLC Stage 0–B1 hepatocellular carcinoma: A multicenter retrospective cohort study The American Journal of Gastroenterology, November 24, 2014 Clinical Article
8 Measurement of gastric emptying in the critically ill Clinical Nutrition, November 24, 2014 Clinical Article
9 Oral anti-CD3 immunotherapy for HCV-nonresponders is safe, promotes regulatory T cells and decreases viral load and liver enzyme levels: Results of a phase-2a placebo-controlled trial Journal of Viral Hepatitis, November 24, 2014 Clinical Article
10 Altered duodenal microbiota composition in celiac disease patients suffering from persistent symptoms on a long-term gluten-free diet The American Journal of Gastroenterology, November 24, 2014 Clinical Article
11 Influence of hepatitis B virus reactivation on the recurrence of HBV-related hepatocellular carcinoma after curative resection in patients with low viral load Journal of Viral Hepatitis, November 24, 2014 Clinical Article
12 Recombinant hepatitis C virus envelope glycoprotein vaccine elicits antibodies targeting multiple epitopes on the envelope glycoproteins associated with broad cross-neutralization Journal of Virology, November 24, 2014 Clinical Article
13 Sorafenib inhibits macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion Journal of Hepatology, November 24, 2014 Clinical Article
14 Increased incidence of inflammatory bowel disease in Québec residents with airway diseases European Respiratory Journal , November 24, 2014 Clinical Article
15 A core outcome set for clinical trials in acute diarrhoea Archives of Diseases in Childhood, November 24, 2014 Clinical Article
16 Nonalcoholic fatty liver disease: A precursor of the metabolic syndrome Digestive and Liver Diseases, November 24, 2014 Clinical Article
17 Treatment of colorectal liver metastases in Germany: A ten-year population-based analysis of 5772 cases of primary colorectal adenocarcinoma Full Text BMC Cancer, November 24, 2014 Clinical Article
18 Childhood malnutrition and the intestinal microbiome Pediatric Research, November 24, 2014 Review Article
19 Association of variants in genes encoding for macrophage-related functions with clinical outcome in patients with loco-regional gastric cancer Annals of Oncology, November 24, 2014 Clinical Article
20 Involvement of adiponectin in early stage of colorectal carcinogenesis Full Text BMC Cancer, November 24, 2014 Clinical Article
Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.
As reported in Digestion, uncontrolled CRP at week 14 of therapy with infliximab (OR=1.36) and early loss of response to infliximab (OR=5.36) are independent risk factors for intra-abdominal abscesses in patients with Crohns disease.
As reported in the Journal of Crohn’s & Colitis, treatment of corticosteroid-refractory ulcerative colitis patients with 3 doses of infliximab (n=113) resulted in short- (3 months) and long-term (12 months) colectomy rates of 18.6% and 25.6%, respectively. The RR of colectomy in patients with an elevated CRP and severe endoscopic lesions was 2.15 and 5.13, respectively.