1Consumption of beer and colorectal cancer incidence: A meta-analysis of observational studiesCancer Causes and Control  Clinical Article  Evidence Based Medicine  Review Article
2Sociocultural and health correlates related to colorectal cancer screening adherence among urban African AmericansCancer Nursing  Clinical Article
3Early Tumor Shrinkage and Depth of Response predict long-term outcome in metastatic colorectal cancer patients treated with first-line chemotherapy plus bevacizumab: results from phase III TRIBE trial by the Gruppo Oncologico del Nord OvestAnnals of Oncology  Clinical Article
4Racial and ethnic disparities in colonoscopic examination of individuals with a family history of colorectal cancerClinical Gastroenterology and Hepatology  Clinical Article
5Relation between vitamin D status and nonalcoholic fatty liver disease in childrenJournal of Pediatric Gastroenterology and Nutrition  Clinical Article
6Coeliac disease screening among a large cohort of overweight/obese childrenJournal of Pediatric Gastroenterology and Nutrition  Clinical Article
7Systematic review with meta-analysis: Pharmacological interventions for eosinophilic oesophagitisAlimentary Pharmacology and Therapeutics  Evidence Based Medicine  Review Article
8Randomised clinical trial: Faecal microbiota transplantation by colonoscopy vs. vancomycin for the treatment of recurrent Clostridium difficile infectionAlimentary Pharmacology and Therapeutics  Clinical Article
9Association between regular aspirin use and circulating markers of inflammation: a study within the prostate, lung, colorectal and ovarian cancer screening trialCancer Epidemiology, Biomarkers & Prevention  Clinical Article
10Preliminary efficacy, safety, pharmacokinetics, pharmacodynamics and quality of life study of pegylated recombinant human arginase 1 in patients with advanced hepatocellular carcinomaInvestigational New Drugs  Clinical Article
1In lab research, SLU team halts NASH liver damageSaint Louis University Health News
2Use of new systemic adjuvant therapy in gastrointestinal tumors (GITSs) increasing, leading to better survivalAmerican Cancer Society News
3Daclatasvir for hepatitis C: Hint of added benefit in genotype 4German Institute for Quality and Efficiency in Health Care (IQWiG)
4Researchers find link between inflammation, tissue regeneration and wound repair responseUC San Diego Health System
5QMUL and Takeda announce research collaboration to develop new therapies in gastroenterologyQueen Mary University of London News
6Crohn's disease not exempt from racial disparitiesNationwide Children's Hospital
7Notes from the field: Cryptosporidiosis associated with consumption of unpasteurized goat milk - Idaho, 2014Morbidity and Mortality Weekly Report
8Gut microbes targeted for diagnosis, treatment of childhood undernutritionWashington University School of Medicine in St. Louis News
9Bariatric surgery affects risk of pregnancy complicationsKarolinska Institutet
10How the landscape of the pancreatic cancer genome is coming into viewGarvan Institute of Medical Research News

Show Me:

Infliximab is effective in corticosteroid-refractory ulcerative colitis

As reported in the Journal of Crohn’s & Colitis, treatment of corticosteroid-refractory ulcerative colitis patients with 3 doses of infliximab (n=113) resulted in short- (3 months) and long-term (12 months) colectomy rates of 18.6% and 25.6%, respectively. The RR of colectomy in patients with an elevated CRP and severe endoscopic lesions was 2.15 and 5.13, respectively.

Risk factors for intra-abdominal abscesses in Crohn’s disease

As reported in Digestion, uncontrolled CRP at week 14 of therapy with infliximab (OR=1.36) and early loss of response to infliximab (OR=5.36) are independent risk factors for intra-abdominal abscesses in patients with Crohn’s disease.

SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

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Clinical Pearls

Clinical Pearl from Smartest DocGERD is one of the most common digestive diseases in the Western world.

Clinical Pearl from Smartest DocPeptic ulcer rebleeding usually occurs within 3 days following endoscopic hemostasis.

Clinical Pearl from Smartest DocRoutine preoperative biliary drainage shows no beneficial effect on the surgical outcome of pancreaticoduodenectomy for periampullary tumor.

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List