We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Oral diets and nutrition support for inflammatory bowel diseaseNutrition in Clinical Practice, June 29, 2015  Review Article
2Efficacy and long-term durability of intradermal recombinant hepatitis B virus vaccine among intramuscular vaccine nonresponders – a prospective study in healthcare personnelJournal of Gastroenterology and Hepatology, June 29, 2015  Clinical Article
3Patients with refractory reflux symptoms often do not have GERDNeurogastroenterology & Motility, June 29, 2015  Clinical Article
4Systematic review: colitis associated with anti-CTLA-4 therapyAlimentary Pharmacology and Therapeutics, June 29, 2015  Review Article
5Increased attentional network functioning related to symptom severity measures in females with irritable bowel syndromeNeurogastroenterology & Motility, June 29, 2015  Clinical Article
6Reduced cell-associated HTLV-2 DNA in antiretroviral treated HIV-1–HCV-coinfected patients who either received interferon-α/ribavirin-based hepatitis C therapy or had spontaneous HCV RNA clearanceJournal of Acquired Immune Deficiency Syndromes, June 29, 2015  Clinical Article
7The empirical antibiotic treatment of nosocomial spontaneous bacterial peritonitis: Results of a randomized controlled clinical trialHepatology, June 29, 2015  Clinical Article
8Prevalence and predictors of hospitalization in Crohn’s disease in a prospective population-based inception cohort from 2000-2012World Journal of Gastroenterology, June 29, 2015  Full Text  Review Article
9The risk of irritable bowel syndrome in patients with endometriosis during a 5-year follow-up: a nationwide population-based cohort studyInternational Journal of Colorectal Disease, June 29, 2015  Clinical Article
10Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancerAnnals of Oncology, June 29, 2015  Clinical Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Risk of bowel cancer reduced by taking aspirin for Lynch syndrome patientsUniversity of Melbourne News, June 29, 2015
2Tiny particles in blood useful for early diagnosis of pancreatic cancerThe University of Texas MD Anderson Cancer Center, June 26, 2015
3UAB among the first to enroll in national clinical trial for novel fecal incontinence treatmentUAB Medicine, June 26, 2015
4Maternal stress alters offspring gut and brain through vaginal microbiomeEndocrine Society News, June 26, 2015
5Study identifies multiple genetic changes linked to increased pancreatic cancer riskJohns Hopkins Medicine, June 26, 2015
6A gel that can make drugs last longerAgency for Science, Technology and Research (A*STAR) News, June 26, 2015
7Discovery targets dormant bowel cancer cells before they form secondary tumoursUniversity of Melbourne News, June 26, 2015
8New approach holds promise for earlier, easier detection of colorectal cancerCalifornia Institute of Technology News, June 26, 2015
9Researchers develop new breath test to diagnose oesophageal and gastric cancerImperial College London Health News, June 25, 2015
10Saliva exoneratedHarvard Medical School News, June 25, 2015

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Calcium reduces CRC risk

As reported in the International Journal of Cancer, there is an 8% reduction in CRC risk with each 300 mg/d increase in calcium intake based on 15 studies involving 12305 patients who took 250-1900 mg of calcium/day over a 3.3-16 year follow-up period. The beneficial effect extended beyond 1000 mg/d.

Risk factors for intra-abdominal abscesses in Crohn’s disease

As reported in Digestion, uncontrolled CRP at week 14 of therapy with infliximab (OR=1.36) and early loss of response to infliximab (OR=5.36) are independent risk factors for intra-abdominal abscesses in patients with Crohn’s disease.

Elevated ?-GT predicts HCC in hepatitis C patients with sustained response

As reported in the Journal of Hepatology, an elevated baseline ɣ-GT level is the strongest predictor of developing HCC in non-cirrhotic patients with hepatitis C and a sustained virologic response (HR = 6.44), followed by age (HR = 3.68).

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Clinical Pearls

Clinical Pearl from Smartest DocTelomere shortening and advanced-stage biliary disease strongly support the telomere hypothesis of human cirrhosis.

Clinical Pearl from Smartest DocBiological therapy for IBD appears to be compatible with use during conception and during pregnancy.

Clinical Pearl from Smartest DocTo date, there is no definitive recommendation for noninvasive imaging of liver fat in children.

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