1A meta-analysis of the utility of C-reactive protein, erythrocyte sedimentation rate, fecal calprotectin, and fecal lactoferrin to exclude inflammatory bowel disease in adults with IBSThe American Journal of Gastroenterology  Clinical Article  Evidence Based Medicine
2Irritable bowel syndrome: a clinical reviewJAMA  Clinical Article  Evidence Based Medicine
3Differentiation of functional constipation and constipation predominant irritable bowel syndrome based on Rome III criteria: a population-based studyAlimentary Pharmacology and Therapeutics  Clinical Article
4Tenofovir rescue therapy in pregnant females with chronic hepatitis BWorld Journal of Gastroenterology  Full Text  Clinical Article
5The efficacy of a second anti-TNF in patients with inflammatory bowel disease whose previous anti-TNF treatment has failedAlimentary Pharmacology and Therapeutics  Evidence Based Medicine  Review Article
6Natural history of bleeding risk in colonic diverticulosis patients: a long-term colonoscopy-based cohort studyAlimentary Pharmacology and Therapeutics  Clinical Article
7Risk factors for acquisition of multidrug-resistant bacteria in patients with anastomotic leakage after colorectal cancer surgeryInternational Journal of Colorectal Disease  Clinical Article
8Impact of retroflexion vs. second forward view examination of the right colon on adenoma detection: a comparison studyThe American Journal of Gastroenterology  Clinical Article
9Hepatitis B virus reactivation and hepatitis in gastrointestinal cancer patients after chemotherapyCancer Chemotherapy and Pharmacology  Clinical Article
10Medical treatment versus surgery for treatment of gastroesophageal reflux diseaseTechniques in Gastrointestinal Endoscopy  Clinical Article
1Understanding how the stomach responds to injury could help target therapy against gastric damageAmerican Gastroenterological Association News
2Whole genome sequencing of pancreatic ductal adenocarcinomasEuropean Society for Medical Oncology News
3Mapping the gut microbiome to better understand its role in obesityGladstone Institutes News
4Gut bacteria may decrease weight loss from bariatric surgery: New study by Cedars-Sinai investigator presented at ENDO 2015 this weekCedars-Sinai
5Gut bacteria may decrease weight loss from bariatric surgeryCedars-Sinai
6Liquid biopsy to improve colorectal cancer careAgency for Science, Technology and Research (A*STAR) News
7Gut bacteria may contribute to diabetes in black malesUniversity of Illinois at Chicago Health News
8Media statement regarding CRE and duodenoscopeCedars-Sinai
9Prescription drug-induced liver failure is uncommon; over-the-counter medications and dietary/herbal supplements are most common causes, Penn study findsPenn Medicine
10Transmission of hepatitis C virus associated with surgical procedures - New Jersey 2010 and Wisconsin 2011Morbidity and Mortality Weekly Report

Show Me:

Infliximab is effective in corticosteroid-refractory ulcerative colitis

As reported in the Journal of Crohn’s & Colitis, treatment of corticosteroid-refractory ulcerative colitis patients with 3 doses of infliximab (n=113) resulted in short- (3 months) and long-term (12 months) colectomy rates of 18.6% and 25.6%, respectively. The RR of colectomy in patients with an elevated CRP and severe endoscopic lesions was 2.15 and 5.13, respectively.

SCCA-IgM predicts survival in HCC patients

As reported in the Journal of Gastroenterology & Hepatology, SCCA-IgM levels are elevated in patients with hepatocellular carcinoma (HCC) compared to patients with cirrhosis and healthy controls. Not only does the SCCA-IgM level predict overall and progression-free survival in HCC patients, but the sensitivity of SCCA-IgM in patients with HCC was 2-fold greater than AFP. A decline in SCCA-IgM levels was shown to be associated with response to treatment.

Decreased PTPN12 expression associated with poor prognosis in HCC

As reported in PLoS ONE, the expression of PTPN12 was decreased in hepatocellular carcinoma tissue samples compared with adjacent normal tissues. Furthermore, decreased PTPN12 expression was associated with tumor recurrence, decreased cancer-specific survival, and decreased recurrence-free survival.

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Clinical Pearls

Clinical Pearl from Smartest DocBei kritisch kranken Patienten mit neurologischen Schäden führt eine Ernährung über Magensonden (verglichen zu Dünndarmsonden) zu einer besseren Deckung des Nährstoffbedarfs.

Clinical Pearl from Smartest DocHohe AFP-Werte könnten ein Ausschlusskriterium für Lebertransplantationen darstellen.

Clinical Pearl from Smartest DocLymph node ratio is a predictor of long-term survival following pancreatic resection for ductal adenocarcinoma.

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List