We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Population pharmacokinetics-pharmacodynamics of vedolizumab in patients with ulcerative colitis and Crohn's diseaseAlimentary Pharmacology and Therapeutics, May 22, 2015  Clinical Article
2Long-term safety of oral nucleos(t)ide analogues for patients with chronic hepatitis B – a cohort study of 53,500 subjectsHepatology, May 22, 2015  Clinical Article
3Constipation prophylaxis reduces length of stay in elderly hospitalized heart failure patients with home laxative useJournal of Gastroenterology and Hepatology, May 22, 2015  Clinical Article
4Persistent reactive thrombocytosis may increase the risk of coronary artery disease among inflammatory bowel disease patientsDigestive Diseases and Sciences, May 22, 2015  Clinical Article
5Pegylated interferon alfa for chronic hepatitis B: Systematic review and meta-analysisJournal of Viral Hepatitis, May 22, 2015  Evidence Based Medicine  Review Article
6Gastrointestinal and hepatic manifestations of Ebola virus infectionDigestive Diseases and Sciences, May 22, 2015  Review Article
7Thyroid function is associated with non-alcoholic fatty liver disease in chronic hepatitis B infected subjectsJournal of Gastroenterology and Hepatology, May 22, 2015  Clinical Article
8Epidemiology of pediatric functional abdominal pain disorders: a meta-analysisPLOS ONE, May 22, 2015  Evidence Based Medicine  Review Article
9Serum diamine oxidase activity as a predictor of gastrointestinal toxicity and malnutrition due to anticancer drugsJournal of Gastroenterology and Hepatology, May 22, 2015  Clinical Article
10Post-diagnostic oral bisphosphonate use and colorectal cancer mortality: a population-based cohort study within the UK Clinical Practice Research DatalinkBritish Journal of Cancer, May 22, 2015  Clinical Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1In study, skipping meals is linked to abdominal weight gainOhio State University News, May 21, 2015
2Helping doctors predict what's next for patients diagnosed with Hepatitis CUniversity of Michigan Health System, May 21, 2015
3Study reveals intestinal bacteria succession during recovery from cholera in BangladeshMassachusetts General Hospital, May 21, 2015
4Liver-sparing operation associated with higher survival rates in cancer patientsAmerican College of Surgeons News, May 20, 2015
5University Hospitals Seidman Cancer Center study finds non-invasive colon cancer screening may be promising for African AmericansUniversity Hospitals Case Medical Center News, May 20, 2015
6New targeted treatment IMMU-130 shows promise in patients with metastatic colon cancerFox Chase Cancer Center News, May 20, 2015
7Expert alert – precision medicine and obesityMayo Clinic, May 20, 2015
8First noninvasive early detection of liver cancer developed by Georgia State researchersGeorgia State University News, May 20, 2015
9VCU-developed compound continues phase 1 clinical trialsVirginia Commonwealth University News, May 20, 2015
10Study finds how pancreatic cancer spreads to liverCornell University Health News, May 20, 2015

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KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

Risk factors for intra-abdominal abscesses in Crohn’s disease

As reported in Digestion, uncontrolled CRP at week 14 of therapy with infliximab (OR=1.36) and early loss of response to infliximab (OR=5.36) are independent risk factors for intra-abdominal abscesses in patients with Crohn’s disease.

Risk factors for CHC-related death identified

As reported in the World Journal of Gastroenterology, the following risk factors for chronic hepatitis C (CHC)-related deaths have been identified (n=8250 CHC patients; n=144 CHC-related deaths): α-IFN therapy (AOR=0.53); liver cirrhosis (AOR=2.89); hepatocellular carcinoma versus CHC (AOR=8.82); hypertension (AOR=1.76); alcohol consumption (AOR=1.73); and HBsAg positivity (AOR=22.28).

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Clinical Pearls

Clinical Pearl from Smartest DocIron deficiency anemia is a risk factor for breath holding spells in children.

Clinical Pearl from Smartest DocFor children with Crohn’s disease, daily supplementation with 2000 IU vitamin D3 is more effective than 400 IU in raising serum 25-hydroxyvitamin D to > 30 ng/mL.

Clinical Pearl from Smartest DocTriple-therapy with high-dose PPI, amoxicillin and doxycycline is not effective in eradicating multidrug-resistant H. pylori.

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