The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists. Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in Gastroenterology. In addition to general news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.
1 Long-term outcomes of thalidomide in refractory Crohn's disease Alimentary Pharmacology and Therapeutics, December 18, 2014 Clinical Article
2 Entecavir vs lamivudine for prevention of hepatitis B virus reactivation among patients with untreated diffuse large B-cell lymphoma receiving R-CHOP chemotherapy: a randomized clinical trial JAMA, December 18, 2014 Evidence Based Medicine Clinical Article
3 Association between baseline impedance values and response proton pump inhibitors in patients with heartburn Clinical Gastroenterology and Hepatology , December 18, 2014 Clinical Article
4 Therapeutic vaccines in treating chronic hepatitis B: The end of the beginning or the beginning of the end? Medical Microbiology and Immunology, December 18, 2014 Clinical Article
5 Antiviral treatment among pregnant women with chronic hepatitis B Full Text Infectious Diseases in Obstetrics and Gynecology, December 18, 2014 Clinical Article
6 Sorafenib therapy for hepatocellular carcinoma with extrahepatic spread: treatment outcome and prognostic factors Journal of Hepatology, December 18, 2014 Clinical Article
7 Role of circulating tumor cells as prognostic marker in resected stage III colorectal cancer Annals of Oncology, December 18, 2014 Clinical Article
8 Protracted fecal shedding of HEV during ribavirin therapy predicts treatment relapse Clinical Infectious Diseases, December 18, 2014 Clinical Article
9 Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid Gastroenterology, December 18, 2014 Clinical Article
10 Charged particle therapy versus photon therapy for patients with hepatocellular carcinoma: A systematic review and meta-analysis Radiotherapy & Oncology, December 18, 2014 Evidence Based Medicine Review Article
11 Meta-analysis of adjunctive non-NK1 receptor antagonist medications for the control of acute and delayed chemotherapy-induced nausea and vomiting Supportive Care in Cancer, December 18, 2014 Evidence Based Medicine Review Article
12 Gene Expression Markers of Efficacy and Resistance to Cetuximab Treatment in Metastatic Colorectal Cancer: Results from CALGB 80203 (Alliance) Clinical Cancer Research, December 18, 2014 Clinical Article
13 Irritable bowel syndrome and the incidence of colorectal neoplasia: a prospective cohort study with community-based screened population in Taiwan British Journal of Cancer, December 18, 2014 Clinical Article
14 Nutrition support can bring survival benefit to high nutrition risk gastric cancer patients who received chemotherapy Supportive Care in Cancer, December 18, 2014 Clinical Article
15 Efficacy and tolerability of rifaximin in combination with lactulose in end-stage liver disease patients with MELD greater than 20: A single center experience Transplantation Proceedings, December 18, 2014 Review Article
16 Antiviral therapy improves postoperative survival in patients with hepatocellular carcinoma: a randomized controlled trial Annals of Surgery, December 18, 2014 Clinical Article
17 A novel continuous stitch fundoplication utilizing knotless barbed suture in children with gastroesophageal reflux disease: A pilot study Journal of Pediatric Surgery, December 18, 2014 Clinical Article
18 A randomized study of the efficacy and safety of transdermal granisetron in the control of nausea and vomiting induced by moderately emetogenic chemotherapy in Korean patients Supportive Care in Cancer, December 18, 2014 Clinical Article
19 DNMT1-microRNA126 epigenetic circuit contributes to esophageal squamous cell carcinoma growth via ADAM9-EGFR-AKT signaling Clinical Cancer Research, December 18, 2014 Clinical Article
20 Effect of endoscopy screening on stage at gastric cancer diagnosis: results of the National Cancer Screening Programme in Korea British Journal of Cancer, December 18, 2014 Clinical Article
As reported in the World Journal of Surgical Oncology, the expression of MMP-9 in colon cancer tissues was increased compared to distal normal mucosa (69.1% vs. 2.9%). Increased MMP-9 expression was associated with lymph node metastasis, Duke stage, and decreased survival.
As reported in the International Journal of Cancer, there is an 8% reduction in CRC risk with each 300 mg/d increase in calcium intake based on 15 studies involving 12305 patients who took 250-1900 mg of calcium/day over a 3.3-16 year follow-up period. The beneficial effect extended beyond 1000 mg/d.
As reported in the World Journal of Gastroenterology, the following risk factors for chronic hepatitis C (CHC)-related deaths have been identified (n=8250 CHC patients; n=144 CHC-related deaths): α-IFN therapy (AOR=0.53); liver cirrhosis (AOR=2.89); hepatocellular carcinoma versus CHC (AOR=8.82); hypertension (AOR=1.76); alcohol consumption (AOR=1.73); and HBsAg positivity (AOR=22.28).