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The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists

  • Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in your uniquely diverse field. In addition to general gastroenterology news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.
  • MDLinx Gastroenterology exclusive content includes: Monthly highlights of the "can't miss" articles chosen by our physician editor, D. Scott Cunningham, MD, PhD; clinical pearls from The Smartest Internist and Smartest Family Physician daily competitions, a collaboration from the editors of MDLinx and Cleveland Clinic Center for Continuing Education; and pearls from our Pediatrics Physician Review quizzes.

Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 The incidence rate of colectomy for medically refractory ulcerative colitis has declined in parallel with increasing anti-TNF use: a time-trend study Alimentary Pharmacology and Therapeutics, July 24, 2014    Clinical Article

2 Cost effectiveness of response-guided therapy with peginterferon in treatment of chronic hepatitis B Clinical Gastroenterology and Hepatology , July 24, 2014    Clinical Article

3 Gene-diet interactions in gastric cancer risk: A systematic review Full Text World Journal of Gastroenterology, July 24, 2014

4 Intravenous corticosteroids in moderately active ulcerative colitis refractory to oral corticosteroids Journal of Crohn's and Colitis, July 24, 2014    Clinical Article

5 Markers of eosinophilic inflammation for diagnosis of eosinophilic esophagitis and proton pumpinhibitor-responsive esophageal eosinophilia: a prospective study Clinical Gastroenterology and Hepatology , July 24, 2014    Clinical Article

6 Patients preferences and health utility assessment with SF-6D and EQ-5D in patients with chronic hepatitis C treated with sofosbuvir regimens Alimentary Pharmacology and Therapeutics, July 24, 2014    Clinical Article

7 The impact of type 2 diabetes and obesity on the long-term outcomes of more than 85 000 liver transplant recipients in the US Alimentary Pharmacology and Therapeutics, July 24, 2014    Clinical Article

8 A phase I dose escalation trial of tremelimumab (CP-675,206) in combination with gemcitabine in chemotherapy-naive patients with metastatic pancreatic cancer Annals of Oncology, July 24, 2014    Clinical Article

9 Radiation plus docetaxel and cisplatin in locally advanced pancreatic carcinoma: A non-comparative randomized phase II trial Digestive and Liver Diseases, July 24, 2014    Clinical Article

10 Bone status and fractures in 85 adults with Wilson's disease Osteoporosis International, July 24, 2014    Clinical Article

11 Acute abdominal emergencies and spinal cord injury; our experiences: a retrospective clinical study Spinal Cord, July 24, 2014    Clinical Article

12 Association of nonalcoholic fatty liver disease with cardiovascular risk factors in obese adolescents: The role of interdisciplinary therapy Journal of Clinical Lipidology, July 24, 2014    Clinical Article

13 A clinical prediction rule for the severity of congenital diaphragmatic hernias in newborns Pediatrics, July 24, 2014    Clinical Article

14 Methodological issues in the study of intestinal microbiota in irritable bowel syndrome Full Text World Journal of Gastroenterology, July 24, 2014    Review Article

15 Immune derived opioidergic inhibition of viscerosensory afferents is decreased in irritable bowel syndrome patients Brain, Behavior, and Immunity, July 24, 2014    Clinical Article

16 Elimination diets in the management of eosinophilic esophagitis Full Text Journal of Asthma and Allergy, July 24, 2014    Review Article

17 Phylogenetic clades 6 and 8 of enterohemorrhagic Escherichia coli O157:H7 with particular stx subtypes are more frequently found in isolates from hemolytic uremic syndrome patients than from asymptomatic carriers Open Forum Infectious Diseases, July 24, 2014    Clinical Article

18 Fluorescence-based endoscopic imaging of thomsen-friedenreich antigen to improve early detection of colorectal cancer International Journal of Cancer, July 24, 2014    Clinical Article

19 A mesenchymal-like phenotype and expression of CD44 predict lack of apoptotic response to sorafenib in liver tumor cells International Journal of Cancer, July 24, 2014    Clinical Article

20 Safety trial of high-intensity focused ultrasound therapy for pancreatic cancer Full Text World Journal of Gastroenterology, July 24, 2014    Clinical Article

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Clinical Pearls in Gastroenterology

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Highlights in Gastroenterology

Increased MMP-9 expression associated with poor prognosis in CRC

As reported in the World Journal of Surgical Oncology, the expression of MMP-9 in colon cancer tissues was increased compared to distal normal mucosa (69.1% vs. 2.9%). Increased MMP-9 expression was associated with lymph node metastasis, Duke stage, and decreased survival.

Decreased PTPN12 expression associated with poor prognosis in HCC

As reported in PLoS ONE, the expression of PTPN12 was decreased in hepatocellular carcinoma tissue samples compared with adjacent normal tissues. Furthermore, decreased PTPN12 expression was associated with tumor recurrence, decreased cancer-specific survival, and decreased recurrence-free survival.

Risk factors for CHC-related death identified

As reported in the World Journal of Gastroenterology, the following risk factors for chronic hepatitis C (CHC)-related deaths have been identified (n=8250 CHC patients; n=144 CHC-related deaths): α-IFN therapy (AOR=0.53); liver cirrhosis (AOR=2.89); hepatocellular carcinoma versus CHC (AOR=8.82); hypertension (AOR=1.76); alcohol consumption (AOR=1.73); and HBsAg positivity (AOR=22.28).

Other Topics in Gastroenterology

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