We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Population pharmacokinetics of infliximab in patients with inflammatory bowel disease: Potential implications for dosing in clinical practiceAlimentary Pharmacology and Therapeutics, July 03, 2015  Clinical Article
2Association of baseline vitamin D levels with clinical parameters and treatment outcomes in chronic hepatitis BJournal of Hepatology, July 03, 2015  Clinical Article
3Dietary polyamine intake and colorectal cancer risk in postmenopausal womenAmerican Journal of Clinical Nutrition, July 03, 2015  Clinical Article
4Cost-effectiveness of strategies for testing current hepatitis C virus infectionHepatology, July 03, 2015  Clinical Article
5Effects of preceding endoscopic mucosal resection on the efficacy and safety of radiofrequency ablation for treatment of Barrett's esophagus: results from the United States Radiofrequency Ablation RegistryDiseases of the Esophagus, July 03, 2015  Clinical Article
6Phase II study of trastuzumab in combination with S-1 and cisplatin in the first-line treatment of human epidermal growth factor receptor HER2-positive advanced gastric cancerCancer Chemotherapy and Pharmacology, July 03, 2015  Clinical Article
7Trastuzumab in combination with docetaxel/cisplatin/S-1 (DCS) for patients with HER2-positive metastatic gastric cancer: Feasibility and preliminary efficacyCancer Chemotherapy and Pharmacology, July 03, 2015  Clinical Article
8Immunogenicity of an investigational hepatitis B vaccine with a toll-like receptor 9 agonist adjuvant (HBsAg-1018) compared with a licensed hepatitis B vaccine in subpopulations of healthy adults 18-70 years of ageVaccine , July 03, 2015  Clinical Article
9Combined Analysis of the Prevalence of drug Resistant HBV in antiviral therapy Experienced patients in Europe (CAPRE)The Journal of Infectious Diseases, July 03, 2015  Clinical Article
10Protease inhibitors to treat hepatitis C in the Swiss HIV Cohort Study: High efficacy but low treatment uptakeHIV Medicine, July 03, 2015  Clinical Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Anxiety increases the risk of gastrointestinal infection and long-term complicationsFlanders Institute for Biotechnology (VIB) News, July 03, 2015
2World GI 2015: Patients with lowest BMI have shortest survival in pooled analysis of bevacizumab in metastatic colorectal cancerEuropean Society for Medical Oncology News, July 03, 2015
3World GI 2015: SENRI trial opens window to evaluate NK1 antagonists for emesis prevention in oxaliplatin chemotherapyEuropean Society for Medical Oncology News, July 03, 2015
4Pinaverium shows promising results for treatment of irritable bowel syndromeAmerican Gastroenterological Association News, July 02, 2015
5Spouses & relatives of celiac disease patients at risk for autoimmune diseasesAmerican Gastroenterological Association News, July 02, 2015
6National study finds life-threatening barriers in access to breakthrough drugsThe Miriam Hospital, July 02, 2015
7Public health surveillance system may seriously underestimate cases of acute hepatitis C infectionMassachusetts General Hospital, July 02, 2015
8Study finds no association between amylase genes, obesityBroad Institute News, July 02, 2015
9Antibiotic treatments could affect pediatric development, animal study suggestsThe Jackson Laboratory News, July 02, 2015
10New hepatitis C treatment needs no antiviral boostJohns Hopkins Medicine, July 02, 2015

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SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

Risk factors for intra-abdominal abscesses in Crohn’s disease

As reported in Digestion, uncontrolled CRP at week 14 of therapy with infliximab (OR=1.36) and early loss of response to infliximab (OR=5.36) are independent risk factors for intra-abdominal abscesses in patients with Crohn’s disease.

Elevated ?-GT predicts HCC in hepatitis C patients with sustained response

As reported in the Journal of Hepatology, an elevated baseline ɣ-GT level is the strongest predictor of developing HCC in non-cirrhotic patients with hepatitis C and a sustained virologic response (HR = 6.44), followed by age (HR = 3.68).

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Clinical Pearls

Clinical Pearl from Smartest DocInfliximab rescue therapy does not appear to reduce long-term surgical rate among pediatric acute severe colitis patients.

Clinical Pearl from Smartest DocScreen-detected children with celiac disease can attain satisfactory dietary adherence and benefit from treatment similarly to symptom-detected patients.

Clinical Pearl from Smartest DocCHD1L may be an independent predictor of overall survival in gastric cancer patients.

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