Gastroenterology News Articles

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The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists. Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in Gastroenterology. In addition to general news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.

Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

1 Treatment of a Crohn's-related cutaneous facial lesion with topical tacrolimus Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, August 1, 2014    Clinical Article

2 Treatment of NASH with vitamins C and E Full Text Hepatic Medicine: Evidence and Research, August 1, 2014    Clinical Article

3 Relationship between tea consumption and pancreatic cancer risk: A meta-analysis based on prospective cohort studies and case-control studies European Journal of Cancer Prevention, August 1, 2014    Evidence Based Medicine    Clinical Article

4 Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis The American Journal of Gastroenterology, August 1, 2014    Clinical Article

5 Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: A randomized clinical trial JAMA, August 1, 2014    Clinical Article

6 Costs of telaprevir-based triple therapy for hepatitis C: $189,000 per sustained virologic response Hepatology, August 1, 2014    Clinical Article

7 Proton pump inhibitor use significantly increases the risk of spontaneous bacterial peritonitis in 1965 patients with cirrhosis and ascites: a propensity score matched cohort study Alimentary Pharmacology and Therapeutics, August 1, 2014    Clinical Article

8 Long-term effect of imiglucerase in Latin American children with Gaucher disease type 1: lessons from the International Collaborative Gaucher Group Gaucher Registry Full Text BMC Hematology, August 1, 2014    Clinical Article

9 Does fecal calprotectin predict short-term relapse after stopping TNFα-blocking agents in inflammatory bowel disease patients in deep remission? Journal of Crohn's and Colitis, August 1, 2014    Clinical Article

10 Managing ambulatory ulcerative colitis patients with infliximab: A long-term follow-up study in primary gastroenterology centers European Journal of Internal Medicine , August 1, 2014    Clinical Article

11 Randomized phase Ib/II trial of rilotumumab or ganitumab with panitumumab versus panitumumab alone in patients with wild-type KRAS metastatic colorectal cancer Clinical Cancer Research, August 1, 2014    Clinical Article

12 Biweekly S-1 plus paclitaxel (SPA) as second-line chemotherapy after failure from fluoropyrimidine and platinum in advanced gastric cancer: a phase II study Cancer Chemotherapy and Pharmacology, August 1, 2014    Clinical Article

13 The role of tenofovir in preventing and treating hepatitis B virus (HBV) reactivation in immunosuppressed patients. A real life experience from a tertiary center European Journal of Internal Medicine , August 1, 2014    Clinical Article

14 Risk factors for serrated polyps of the colorectum Digestive Diseases and Sciences, August 1, 2014    Clinical Article

15 Gastroretentive drug delivery systems for the treatment of Helicobacter pylori Full Text World Journal of Gastroenterology, August 1, 2014    Review Article

16 Can celiac serology alone be used as a marker of duodenal mucosal recovery in children with celiac disease on a gluten-free diet? The American Journal of Gastroenterology, August 1, 2014    Clinical Article

17 The nutritional and pharmacological consequences of obesity surgery Alimentary Pharmacology and Therapeutics, August 1, 2014    Review Article

18 Elevation of PRKCDBP, a novel transcriptional target of TNF- α, and its downregulation by infliximab in patients with ulcerative colitis Digestive Diseases and Sciences, August 1, 2014    Clinical Article

19 Stool microbiota and vaccine responses of infants Pediatrics, August 1, 2014    Clinical Article

20 HCV RNA viral load is independent from CD4 cell count and plasma HIV RNA viral load in immunocompetent HIV-HCV co-infected patients: A 3-years follow-up study Full Text AIDS Research and Therapy, August 1, 2014    Clinical Article

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Highlights in Gastroenterology

KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

Increased MMP-9 expression associated with poor prognosis in CRC

As reported in the World Journal of Surgical Oncology, the expression of MMP-9 in colon cancer tissues was increased compared to distal normal mucosa (69.1% vs. 2.9%). Increased MMP-9 expression was associated with lymph node metastasis, Duke stage, and decreased survival.


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