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The effect of local gentamicin-collagen on perineal wound complications and cancer recurrence after abdominoperineal resection: a multicentre randomised controlled trial
Colorectal Disease, 08/20/2012
Clinical Article
Collin A et al. – There was no statistically significant effect on perineal wound complications or cancer recurrence following the local administration of gentamicin–collagen during abdominoperineal resection of the rectum (APR).
Methods- In this prospective multicentre (7 hospitals) randomised controlled trial, 102 patients undergoing APR due to cancer or benign disease were randomised into two groups including surgery with gentamicin–collagen (GS+ n=52), or surgery without gentamicin–collagen (GS– n=50), Patients were followed at 7, 30 and 90 days and at one and five years.
- There were no statistically significant differences between the two groups regarding perineal wound complications, infectious or non–infectious or cancer recurrence.
