MINT31 methylation in gastric noninvasive neoplasia: potential role in the secondary prevention of gastric cancer
European Journal of Cancer Prevention, 07/27/2012
Negrini M et al. – The data support a progressive accumulation of aberrant methylations in noninvasive neoplasia (NIN) and Gastric cancer (GC) at various CpG islands with distinct time courses. With hypermethylation, the genes involved in regulating the balance between apoptosis and cell proliferation may become silenced and trigger gastric tumorigenesis. Hypermethylation of MINT31 predicted NIN persistence, as well as progression to higher grade or to GC, and might be used as a marker of GC risk.