Decreased Immunoexpression of Standard Form of CD44 Is an Independent Favourable Predictor of Nodal Metastasis in Colorectal Carcinoma
Anticancer Research, 07/27/2012
Al–MaghrabiI J et al. – Loss of CD44s immunolabelling in colorectal carcinomas (CRC) is an independent favourable predictor of regional lymph node metastasis. On the other hand, CD44s loss has no significant association with disease recurrence or survival. Extensive in vivo and in vitro molecular studies are required to elucidate the possible mechanistic association of CD44s with tumour initiation, progression, invasion and metastasis in primary CRC, and in nodal and distant metastases.