The clinical characteristics of gastroesophageal reflux disease in patients with laryngeal symptoms who are referred to gastroenterology
Diseases of the Esophagus, 08/08/2012
Oh JH et al. – The presence of typical reflux symptoms and dyspepsia are risk factors for gastroesophageal reflux disease (GERD) in patients who present with laryngeal symptoms.Methods
- Data were gathered retrospectively from patients who presented with atypical symptoms, such as throat discomfort, globus pharyngeus, hoarseness, and chronic cough.
- They underwent a 24-hour ambulatory intraesophageal pH monitoring and filled in a validated reflux questionnaire.
- Overall, 128 patients (36 men and 92 women) with laryngeal symptoms were included.
- Of these 128, 43 patients (34%) had erosive esophagitis or pathological reflux from 24-hour ambulatory pH monitoring, and 24 (19%) had a positive Bernstein test or positive symptom index from 24-hour pH monitoring.
- Sixty-one patients (48%) had no evidence of reflux esophagitis on upper endoscopy and pathological acid reflux on 24-hour pH monitoring.
- Fifty-six patients (44%) had weekly heartburn or regurgitation.
- Typical symptoms and dyspepsia were significantly more common in patients with GERD who had laryngeal symptoms than non-GERD.
- Fifty-two percent of patients had laryngeal symptoms that were associated with GERD.