Prevalence of Celiac Disease in Indian Children with Down Syndrome and its Clinical and Laboratory Predictors
The Indian Journal of Pediatrics, 07/18/2012
Bhat AS et al. – The present results showed a high prevalence of celiac disease (CD) in DS children in a tertiary hospital in India and low hemoglobin to be an important risk factor. The authors recommend that all Indian children with Down syndrome, particularly those with anemia should be screened for celiac disease.Methods
- Prevalence of celiac disease (CD) was assessed in 100 patients with Down syndrome (DS) attending pediatric genetic clinic at All India Institute of Medical Sciences,in a prospective observational study, based on the characteristic symptomatology, positive indirect immunofluorescence anti endomyseal antibody(anti EMA) test and duodenal histology based on adapted Marsh criteria.
- Anti EMA was positive in 7 out of 100 patients screened for CD; 6 in whom the duodenal biopsy could be done showed histopathological features consistent with celiac disease.
- Amongst various clinical features evaluated as possible risk factors; pallor reached statistical significance. In addition anemia (Hb <11 g%) was significantly associated with CD.