Rate of onset of inhibition of gut-wall and hepatic CYP3A by clarithromycin
European Journal of Clinical Pharmacology, 07/31/2012
Quinney SK et al. – Following the administration of clarithromycin, the onset of hepatic CYP3A inactivation is delayed compared to that of intestinal CYP3A. The time–course of drug–drug interactions due to clarithromycin will vary with the relative contribution of intestinal and hepatic CYP3A to the clearance and bioavailability of a victim substrate.