Plasma 25-Hydroxyvitamin D Levels Are Favorably Associated With β-Cell Function
Karnchanasorn R et al. – Plasma 25(OH)D levels are positively association with both β–cell function and insulin sensitivity. The observations suggest the roles of vitamin D deficiency in the dual defect of type 2 diabetes.Methods
- The authors enrolled 150 healthy, glucose-tolerant subjects for the assessment of β-cell function (acute insulin response) and insulin sensitivity index (ISI) using a hyperglycemic clamp.
- Adjusted β-cell function (ABCF) was defined as the product of acute insulin response and ISI.
- The relations of plasma 25-hydroxyvitamin D [25(OH)D] level with insulin sensitivity and ABCF were examined.
- Plasma 25(OH)D levels were positively associated with ABCF (P=0.00004) and ISI (P<0.00001).
- The associations remained significant after adjustment for age, sex, body mass index, physical activity, ethnicity, and season of study.