Resistance to TRAIL is mediated by DARPP-32 in gastric cancer

Clinical Cancer Research, 05/17/2012

The findings uncover a novel mechanism of TRAIL resistance mediated by DARPP–32, whereby it inhibits the intrinsic apoptosis pathway through up–regulation of BCL–xL, and the extrinsic apoptosis pathway through the NF–κB/FLIP(S) axis.

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