Impact of esophageal invasion on clinicopathological characteristics and long-term outcome of adenocarcinoma of the subcardia
Journal of Surgical Oncology, 05/21/2012
Tokunaga M et al. – Esophageal invasion affected the clinicopathological characteristics and long–term outcome of patients. Further study is necessary to clarify whether patients with esophageal invasion should be classified using the system for esophageal cancer or by another method.Methods
- The present study included 351 patients who underwent gastrectomy for adenocarcinoma located within 5 cm of the esophagogastric junction.
- The clinicopathological characteristics and survival curves were compared between patients with esophageal invasion [E (+) group, n=125] and without esophageal invasion [E (-) group, n=226].
- Patients in the E (+) group had more advanced disease.
- The 5–year survival rate following macroscopic curative resection was significantly better in the E (-) group (80.8%) than in the E (+) (48.7%, P<0.001), even after stratification by the pathological stage and nodal status.
- Multivariate analysis identified esophageal invasion (hazard ratio; 3.323, 95% confidential interval; 1.815–6.082) as one of the independent prognostic factors.