Oral immunotherapy induces local protective mechanisms in the gastrointestinal mucosa
The Journal of Allergy and Clinical Immunology, 05/04/2012
Leonard SA et al. – Oral immunotherapy (OIT) results in clinical protection against food–induced anaphylaxis through a novel mechanism that is localized to the intestinal mucosa and is associated with significant changes in small intestinal gene expression. Extensively heating egg allergen decreases allergenicity and increases safety while still retaining the ability to induce effective desensitization.