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Clinicopathological characteristics and prognosis of patients with esophageal carcinoma invading adjacent structures found during esophagectomy
Journal of Surgical Oncology, 04/18/2012
Kosugi SI et al. – The complete resection rate was low and the prognosis of patients with sT4 tumors was poor. Subclassification according to the invaded structures was not a prognostic factor in this study. Postoperative therapy may improve survival in sT4 patients and should be considered irrespective of residual tumor status after esophagectomy.
Methods- A consecutive series of 76 patients who were found to have sT4 tumors was reviewed retrospectively.
- T4 tumors were divided into two groups according to the invaded structures.
- Cox's multivariate proportional hazard model was used to identify prognostic factors.
- Complete tumor clearance with combined resection was performed in 12 patients (16%).
- Overall 1–, 3–, and 5–year survival rates were 40.8%, 9.2%, and 7.9%, respectively.
- There was no significant relationship between survival and invaded structure type or residual tumor status.
- Postoperative therapy was selected as an independent prognostic factor.
