Systematic review: antibodies and anti-TNF- levels in inflammatory bowel disease
Alimentary Pharmacology and Therapeutics,  Clinical Article

Chaparro M et al. – Measurement of serum anti–TNF– α trough levels and antibody titres could prove useful in therapeutic drug monitoring in inflammatory bowel disease (IBD) patients treated with anti–TNF– α agents.

Methods
  • A systematic review was undertaken based on electronic searches of the PubMed database from the earliest record to February 2012.
  • The reference lists of all relevant articles and abstracts from meetings were also consulted.

Results
  • The authors observed a close relationship between trough levels of anti-TNF- α drug and maintenance of response to these drugs.
  • The role of antibodies in loss of response seems to be limited to their effect favouring the clearance of the drug.
  • The risk of infusion reactions, but not of delayed hypersensitivity reactions, is higher in patients with antibodies against the anti-TNF-α drug.
  • Testing anti-TNF-α drug and antibody levels, together with clinical and endoscopic or radiological assessment, seems useful when attempting to optimise therapy and prevent inappropriate management of IBD patients.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

    Currently, there are no available articles.

Your Unread Messages in Gastroenterology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Gastroenterology Articles

Indexed Journals in Gastroenterology: Gastroenterology, American Journal of Gastroenterology, Gutmore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close