High-dose rabeprazole-amoxicillin dual therapy and rabeprazole triple therapy with amoxicillin and levofloxacin for 2 weeks as first and second line rescue therapies for Helicobacter pylori treatment failures
Alimentary Pharmacology and Therapeutics, 03/12/2012
Goh KL et al. – A 2–week high dose proton pump inhibitor (PPI)–amoxicillin dual therapy followed by a PPI–amoxicillin–levofloxacin triple therapy were highly successful in achieving eradication in H. pylori treatment failures.Methods
- Consecutive patients who failed the proton pump inhibitor (PPI) 1-week triple therapy were recruited for the study.
- H. pylori status was determined by a C13 urea breath test.
- One hundred and forty-nine patients received the first rescue therapy.
- Seven were not compliant to medication/defaulted follow-up.
- Eradication success- first rescue therapy: per protocol (PP) analysis-107/142 (75.4%) (95% CI (68.3-82.4%) and intention to treat (ITT) analysis-107/149 (71.8%) 95% CI (64.6-79.0%).
- Thirty-one of 35 patients who failed the first rescue therapy received the second rescue therapy.
- All were compliant with medications.
- Eradication success- PP and ITT was 28/31 (90.3%) 95% CI (74.2-98.0%).
- The cumulative eradication rate using both rescue therapies: PP analysis- 135/138 (97.8%) 95% CI: (93.8-99.6%), ITT analysis- 135/149 (90.6%) 95% CI: (84.7-94.8%).