Rifaximin-Extended Intestinal Release Induces Remission in Patients With Moderately Active Crohns Disease
Gastroenterology,  Clinical Article

Prantera C et al. – Administration of 800 mg rifaximin–extended intestinal release (EIR) twice daily for 12 weeks induced remission with few adverse events in patients with moderately active Crohn's disease (CD).

Methods
  • The authors performed a multicenter, randomized, double-blind trial of the efficacy and safety of 400, 800, and 1200 mg rifaximin-EIR, given twice daily to 402 patients with moderately active CD for 12 weeks.
  • Data from patients given rifaximin-EIR were compared with those from individuals given placebo, and collected during a 12-week follow-up period.
  • The primary end point was remission (Crohn's Disease Activity Index <150) at the end of the treatment period.

Results
  • At the end of the 12-week treatment period, 62% of patients who received the 800-mg dosage of rifaximin-EIR (61 of 98) were in remission, compared with 43% of patients who received placebo (43 of 101) (P = .005).
  • A difference was maintained throughout the 12-week follow-up period (45% [40 of 89] vs 29% [28 of 98]; P = .02).
  • Remission was achieved by 54% (56 of 104) and 47% (47 of 99) of the patients given the 400-mg and 1200-mg dosages of rifaximin-EIR, respectively; these rates did not differ from those of placebo.
  • Patients given the 400-mg and 800-mg dosages of rifaximin-EIR had low rates of withdrawal from the study because of adverse events; rates were significantly higher among patients given the 1200-mg dosage (16% [16 of 99]).

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Gastroenterology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Gastroenterology Articles

1 Screening prior to biological therapy in Crohn's disease: Adherence to guidelines and prevalence of infections. Results from a multicentre retrospective study Digestive and Liver Diseases, August 4, 2014    Clinical Article

2 The probiotic VSL#3 has anti-inflammatory effects and could reduce endoscopic recurrence following surgery for Crohn's disease Clinical Gastroenterology and Hepatology , November 7, 2014    Clinical Article

3 Systematic review: new serological markers (anti-glycan, anti-GP2, anti-GM-CSF Ab) in the prediction of IBD patient outcomes Autoimmunity Reviews, November 19, 2014    Evidence Based Medicine    Review Article

4 Higher vitamin D serum concentration increases health related quality of life in patients with inflammatory bowel diseases Full Text World Journal of Gastroenterology, November 17, 2014    Free full text    Clinical Article

5 Magnetic resonance enterocolonography is highly detectable of erosion and redness in intestinal mucosa of patients with Crohn's disease Journal of Gastroenterology and Hepatology, November 20, 2014    Clinical Article

6 Risk of lymphoma in patients with inflammatory bowel disease treated with azathioprine and 6-mercaptopurine: a meta-analysis Clinical Gastroenterology and Hepatology , June 25, 2014    Evidence Based Medicine    Clinical Article

7 Predictors of response to steroid therapy for eosinophilic esophagitis and treatment of steroid-refractory patients Clinical Gastroenterology and Hepatology , September 19, 2014    Clinical Article

8 Re-treatment of chronic hepatitis C virus genotype 1 infection after relapse: an open-label pilot study Annals of Internal Medicine, November 11, 2014    Evidence Based Medicine    Clinical Article

9 Clinical utility and diagnostic accuracy of faecal calprotectin for IBD at first presentation to gastroenterology services in adults aged 16-50years Journal of Crohn's and Colitis, September 8, 2014    Clinical Article

10 Lactulose vs polyethylene glycol 3350-electrolyte solution for treatment of overt hepatic encephalopathy: the help randomized clinical trial JAMA Internal Medicine, October 13, 2014    Evidence Based Medicine    Clinical Article

11 The use of sirolimus (rapamycin) in the management of refractory inflammatory bowel disease in children Journal of Crohn's and Colitis, November 3, 2014    Clinical Article

12 The impact of timing and duration of thiopurine treatment on colectomy in ulcerative colitis: A national population-based study of incident cases between 1989–2009 Alimentary Pharmacology and Therapeutics, November 12, 2014    Clinical Article

13 Consumption of garlic and risk of colorectal cancer: An updated meta-analysis of prospective studies Full Text World Journal of Gastroenterology, November 18, 2014    Free full text    Evidence Based Medicine

14 Association between serrated polyps and the risk of synchronous advanced colorectal neoplasia in average-risk individuals Alimentary Pharmacology and Therapeutics, October 27, 2014    Clinical Article

15 Idiopathic inflammatory demyelinating disease of the central nervous system in patients with inflammatory bowel disease: retrospective analysis of 9095 patients Alimentary Pharmacology and Therapeutics, November 4, 2014    Clinical Article

16 Timing of rebleeding in high-risk peptic ulcer bleeding after successful hemostasis: A systematic review Canadian Journal of Gastroenterology, November 12, 2014    Review Article

17 Risk of lymphoma in patients with inflammatory bowel disease treated with azathioprine and 6-mercaptopurine: a meta-analysis Clinical Gastroenterology and Hepatology , September 25, 2014    Clinical Article

18 The relationship between infliximab concentrations, antibodies to infliximab and disease activity in Crohn's disease Gut, November 13, 2014    Clinical Article

19 High-dose dual therapy is superior to standard first-line or rescue therapy for Helicobacter pylori infection Clinical Gastroenterology and Hepatology , November 21, 2014    Clinical Article

20 Risk of upper gastrointestinal bleeding from different drug combinations Gastroenterology, October 13, 2014    Clinical Article

Indexed Journals in Gastroenterology: Gastroenterology, American Journal of Gastroenterology, Gutmore