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The Effects of an Oral Supplement Enriched With Fish Oil, Prebiotics, and Antioxidants on Nutrition Status in Crohn's Disease Patients
Nutrition in Clinical Practice, 08/01/2011
Dawn M. Wiese et al. – Inflammatory bowel disease nutrition formula (IBDNF) has the potential to deposit fat–free and fat mass, improve vitamin D status, and improve quality of life in Crohn’s disease (CD) patients.
Methods- Open–label pilot study investigating the effects of IBDNF on nutrition status in CD patients
- 28 patients with active CD on stable medication were asked to consume 16 oz of IBDNF/d for 4 months
- Nutrition status was assessed with dual–energy X–ray absorptiometry scans and serum micronutrient levels
- Disease activity and quality of life were measured using the Crohn’s Disease Activity Index (CDAI) and the Inflammatory Bowel Disease Questionnaire (IBDQ)
- 20 patients completed the final visit
- After 4 months, there was a significant decrease in plasma phospholipid levels of arachidonic acid with increases in eicosapentaenoic acid (EPA) and docosahexaenoic acid
- 10 patients had a final EPA concentration of >2%
- There was improvement in fat–free and fat mass in patients with final EPA >2% (P = .014 and P = .05)
- Vitamin D (25–OH) levels improved in all patients (18.5–25.9 ng/mL, P < .001)
- Those with EPA >2% had significantly lower CDAI (116 ± 94.5 vs 261.8 ± 86.5; P = .005) and higher IBDQ (179.1 ± 26.6 vs 114.6 ± 35.9, P < .001) compared to those with EPA <2%
