Expression Pattern, Ethanol-Metabolizing Activities, and Cellular Localization of Alcohol and Aldehyde Dehydrogenases in Human Small Intestine

Alcoholism: Clinical and Experimental Research, 06/12/2012

Alcohol dehydrogenase and aldehyde dehydrogenase isozymes are differentially expressed in the various cell types of duodenum and jejunum. The results suggest that proximal small intestine can substantively contribute to first–pass metabolism of ethanol under certain conditions and that cytotoxic acetaldehyde and ethanol perturbation of retinol metabolism might play an etiological role in the pathogenesis of small bowel.

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