A clinicopathological and immunohistochemical study of gastric cancer with squamous cell carcinoma components: A clinically aggressive tumor
Journal of Digestive Diseases, 05/31/2012Saito S et al.
Squamous cell carcinoma (SCC) components are derived from squamous metaplasia in a preexisting adenocarcinoma. Gastric adenocarcinoma with SCC components is associated with various patterns of metastasis, both SCC and adenocarcinoma components have the potential for metastasis. Gastric cancer with SCC components is a clinically aggressive tumor.
From January 2001 through June 2010, a total of 1735 patients underwent resection of gastric cancer.
Histopathologically, 8 patients were adenocarcinoma containing SCC components, in which the proportion of SCC components was above 25% of the total tumor mass in 4 patients.
The immunohistochemical and clinicopathological characteristics of these eight patients were analyzed.
The median survival duration was 25 months.
Adenocarcinoma was present at the superficial layer of all tumors and SCC was primarily present at sites with deep invasion.
Immunohistochemically, adenocarcinoma components were positive for CAM5.2 and CK7 in all cases.
SCC components were positive for CEA and CK7 in more than 60% of cases.
Expression patterns of p53 product were identical in both components.
SCC components were positive for 34bE12, and adenocarcinoma components were negative for 34bE12 in all cases.
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