Intestinal aganglionosis is associated with early and sustained disruption of the colonic microbiome

Neurogastroenterology & Motility, 05/31/2012

The differences observed suggest a potential contributory role for the microbiome in the etiology of Hirschsprung’s–associated enterocolitis (HAEC). These findings provide a basis for further studies to determine the causative role of specific bacterial communities in HAEC and the potential to restore the normal microbiome in Hirschsprung’s disease.

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