Fecal MMP-9: A new noninvasive differential diagnostic and activity marker in ulcerative colitis
Inflammatory Bowel Disease, 05/16/2012Annahazi A et al.
The results highlight fecal metalloprotease 9 (MMP–9) as a useful tool in the differential diagnosis of diarrheic disorders and in the noninvasive evaluation of disease activity and mucosal healing in Ulcerative colitis (UC).
UC (n=47), IBS–D (n=23) patients, and control subjects (n=24) provided fecal samples for MMP–9 analysis.
In UC patients, disease severity was evaluated by the Mayo score.
Fecal MMP–9 and calprotectin levels were measured by enzyme–linked immunosorbent assay and lateral flow assay, respectively.
MMP–9 was undetectable or ≤0.22 ng/mL in the feces of all controls and IBS–D patients.
In UC patients, fecal MMP–9 levels significantly correlated with the overall Mayo score (P < 0.001), the endoscopic score (P<0.001), and the serum C–reactive protein levels (P=0.002).
Additionally, in UC patients fecal MMP–9 levels showed a significant correlation with a known disease activity marker, fecal calprotectin (P = 0.014).
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