Des-γ-carboxyl prothrombin is associated with tumor angiogenesis in hepatocellular carcinoma
Journal of Gastroenterology and Hepatology, 05/16/2012Matsubara M et al.
Des– γ–carboxyl prothrombin (DCP) production is associated with tumor angiogenesis in Hepatocellular carcinoma (HCC).
The solitary HCCs of 827 patients were classified into 2 groups according to the tumor density at the arterial phase of a dynamic computed tomography scan; the initial clinical data of patients with the hyper- and hypovascular types were compared.
The HCC tissues from 95 tumors were analyzed by immunohistochemical staining for DCP and phosphorylated KDR, and intratumoral microvessel density (MVD) was analyzed to evaluate microvessel angiogenesis.
The serum DCP levels (320 ± 3532 mAU/mL) and tumor size (18.4 ± 9.0 mm) of patients with hypervascular HCC were significantly greater than those with hypovascular HCC (38.7 ± 80 mAU/mL and 14.6 ± 5.2 mm, P < 0.001).
Immunohistochemical analysis revealed that the expressions of DCP and phospho-KDR were significantly greater in hypervascular HCC (71.4% and 31.0%, respectively) than in hypovascular HCC (7.6% and 5.7%, respectively).
Intratumoral MVD was significantly correlated with DCP (r = 0.48, P < 0.0001).
MDLinx connects healthcare professionals and patients to tomorrow's important medical news, while providing the pharmaceutical and healthcare industries with highly targeted interactive marketing, education, content, and medical research solutions.