Anti-tumor necrosis factor and postoperative complications in Crohns disease: systematic review and meta-analysis
Inflammatory Bowel Disease, 04/26/2012Kopylov U et al.
Preoperative infliximab treatment is associated with an increased risk of postoperative infectious complications, mostly nonlocal. A trend toward an increased risk of noninfectious and overall complications was also observed.
A systematic review and meta-analysis of comparative cohort studies was performed assessing postoperative complication rates in CD patients who were treated with anti-TNF antibodies within 3 months before surgery versus patients who were not.
The primary outcome was overall complication rate within 1 month of surgery.
Secondary outcomes included the rate of infectious and noninfectious complications.
The quality of studies was assessed based on selection of patients and controls, comparability of the study groups, and assessment of outcomes.
Odds ratios (OR) with 95% confidence intervals (CIs) were computed.
A total of eight studies including 1641 patients were included in the meta-analysis.
Preoperative infliximab therapy in CD patients undergoing abdominal surgery was associated with a trend toward an increased rate of total complications (OR 1.72, 95% CI, 0.93-3.19).
Anti-TNF treatments were associated with a modestly increased risk of infectious complications (OR 1.50, 95% CI 1.08-2.08), mostly remote from the surgical site (OR 2.07 95% CI 1.30-3.30) and with a trend toward a higher rate of noninfectious complications (OR 2.00, 95% CI 0.89-4.46).
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