Association of dietary fat intakes with risk of esophageal and gastric cancer in the NIH-AARP diet and health study
International Journal of Cancer, 04/24/2012
O'Doherty MG et al. – The authors found null associations between the dietary fat intakes with esophageal or gastric cancer risk; although a protective effect of polyunsaturated fat intake was seen for esophageal adenocarcinoma (EAC) in subjects with a normal body mass index (BMI).
From 1995-1996, dietary intake data was reported by 494,978 participants of the NIH-AARP cohort.
The 630 EAC, 215 ESCC, 454 gastric cardia and 501 gastric noncardia adenocarcinomas accrued to the cohort.
Cox proportional hazards regression was used to examine the association between the dietary fat intakes, whilst adjusting for potential confounders.
Although apparent associations were observed in energy-adjusted models, multivariate adjustment attenuated results to null [e.g., EAC energy adjusted hazard ratio (HR) and 95% confidence interval (95% CI) 1.66 (1.27-2.18) p for trend <0.01; EAC multivariate adjusted HR (95% CI) 1.17 (0.84-1.64) p for trend=0.58].
Similar patterns were also observed for fat subtypes [e.g., EAC saturated fat, energy adjusted HR (95% CI) 1.79 (1.37-2.33) p for trend <0.01; EAC saturated fat, multivariate adjusted HR (95% CI) 1.27 (0.91-1.78) p for trend=0.28].
However, in multivariate models an inverse association for polyunsaturated fat (continuous) was seen for EAC in subjects with a body mass index (BMI) in the normal range (18.5-<25kg/m2) [HR (95% CI) 0.76 (0.63-0.92)], that was not present in overweight subjects [HR (95% CI) 1.04 (0.96-1.14)], or in unstratified analysis [HR (95% CI) 0.97 (0.90-1.05)]. p for interaction=0.02.
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