Activation of Colonic Mucosal 5-HT4 Receptors Accelerates Propulsive Motility and Inhibits Visceral Hypersensitivity
Gastroenterology, 04/10/2012Hoffman JM et al.
Mucosal 5–HT4 receptor activation can mediate the prokinetic and antinociceptive actions of 5–HT4R agonists. Colon–targeted, intraluminal delivery of 5–HT4R agonists might be used to promote motility and alleviate visceral pain, while restricting systemic bioavailability and resulting adverse side effects.
MDLinx connects healthcare professionals and patients to tomorrow's important medical news, while providing the pharmaceutical and healthcare industries with highly targeted interactive marketing, education, content, and medical research solutions.