Establishment and characterization of novel gastric signet-ring cell and non signet-ring cell poorly differentiated adenocarcinoma cell lines with low and high malignant potential

Gastric Cancer, 04/04/2012

The results indicate that the cells of the new signet–ring cell carcinoma (SRCC) line, GPM–2 cells, are more differentiated and less aggressive than non signet–ring cell carcinoma (NSRCC)–type GPM–1 cells, and would thus offer an excellent model for understanding the molecular mechanism underlying the growth, differentiation, and production of an SRCC gastric cancer cell line.

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