Arginase-1: A novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology

Cancer Cytopathology, 03/22/2012

This study demonstrates that both arginase–1 and HepPar–1 are effective immunohistochemistry (IHC) markers of hepatocellular differentiation. Furthermore, arginase–1 demonstrates superior sensitivity compared with GPC–3 and HepPar–1 in the diagnosis of HCC, whereas GPC–3 demonstrates superior specificity, as staining is not observed in benign hepatocellular lesions. Hence, use of arginase–1 with HepPar–1 and GPC–3 can aid in the diagnosis of HCC and separating from metastatic carcinoma.

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