Available now at MDLinx Gastroenterology: Ranked summaries of the most clinically-relevant GI literature refreshed every 24 hours, as well as MDLinx Gastroenterology exclusive content
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1 Management of active crohn disease JAMA, May 23, 2013 Evidence Based Medicine Clinical Article
2 Sustained clinical benefit and tolerability of methotrexate monotherapy after thiopurine therapy in patients with crohns disease Clinical Gastroenterology and Hepatology , May 23, 2013 Clinical Article
3 Intragastric acidity and omeprazole exposure during dosing with either PA32540 (enteric-coated aspirin 325 mg + immediate-release omeprazole 40 mg) or enteric-coated aspirin 325 mg + enteric-coated omeprazole 40 mg – a randomised, phase 1, crossover study Alimentary Pharmacology and Therapeutics, May 23, 2013 Clinical Article
4 Nonsteroidal anti-inflammatory drug use, chronic liver disease, and hepatocellular carcinoma Hepatology, May 23, 2013 Clinical Article
5 Phase III randomized, placebo-controlled study of cetuximab plus brivanib alaninate versus cetuximab plus placebo in patients with metastatic, chemotherapy-refractory, wild-type k-ras colorectal carcinoma Journal of Clinical Oncology, May 23, 2013 Clinical Article
6 Cardiovascular risk factors among long-term survivors of breast, prostate, colorectal, and gynecologic cancers: a gap in survivorship care? Journal of Cancer Survivorship, May 23, 2013 Review Article
7 Seroprotection after recombinant hepatitis B vaccination among newborn infants: A review Vaccine , May 23, 2013 Review Article
8 Treatment of patients with dual hepatitis C and B by peginterferon {alpha} and ribavirin reduced risk of hepatocellular carcinoma and mortality Gut, May 23, 2013 Clinical Article
9 The presence of coronary artery disease increases the risk of biliary events in patients with asymptomatic gallstones Journal of Gastroenterology and Hepatology, May 23, 2013 Clinical Article
10 Abdominal pain is associated with anxiety and depression scores in a sample of the general adult population with no signs of organic gastrointestinal disease Neurogastroenterology & Motility, May 23, 2013 Clinical Article
11 Childhood maltreatment and obesity: systematic review and meta-analysis Full Text Molecular Psychiatry, May 23, 2013 Evidence Based Medicine Review Article
12 Signal transducer and activator of transcription 3 (STAT3) is a pro-viral host factor for hepatitis C virus Hepatology, May 23, 2013 Review Article
13 Genotype 4 hepatitis E virus in France: an autochthonous infection with a more severe presentation Clinical Infectious Diseases, May 23, 2013 Clinical Article
14 Theory of mind deficits in patients with esophageal cancer combined with depression Full Text World Journal of Gastroenterology, May 23, 2013 Clinical Article
15 Response evaluation criteria in solid tumors (recist) criteria are superior to european association for study of the liver (easl) criteria at 1 month follow-up for predicting long-term survival in patients treated with transarterial chemoembolization before liver transplantation for hepatocellular cancer Journal of Vascular and Interventional Radiology, May 23, 2013 Review Article
16 Effectiveness of treatment summaries in increasing breast and colorectal cancer survivors’ knowledge about their diagnosis and treatment Journal of Cancer Survivorship, May 23, 2013 Review Article
17 How long will it take to reduce gastric cancer incidence by eradicating Helicobacter pylori infection? Cancer Prevention Research, May 23, 2013 Clinical Article
18 Hepatic steatosis and severity-related factors in obese children Journal of Gastroenterology and Hepatology, May 23, 2013 Review Article
19 Reflux symptoms and side effects among patients with gastroesophageal reflux disease at baseline, during treatment with ppis, and after nissen fundoplication World Journal of Surgery, May 23, 2013 Clinical Article
20 DNA methylation biomarkers for non-invasive diagnostic of Colorectal Cancer Cancer Prevention Research, May 23, 2013 Clinical Article
As published in the NEJM, researchers in the COLONPREV study (Spain) have reported that fecal immunochemical testing (FIT) is as effective as colonoscopy in the detection of colorectal cancer (CRC). The study population was 50-69 years of age and comprised of 26,703 subjects who underwent a one-time colonoscopy and 26,599 subjects who underwent FIT every 2 years. The primary outcome measure was CRC deaths at 10 years. Participation in screening was greater in the FIT group than the colonoscopy group (34.2% vs. 24.6%). Detection of CRC was similar between the two groups (0.1%). Advanced and non-advanced adenomas were detected more frequently in the colonoscopy group than the FIT group (1.9% vs. 0.9% [OR=2.3] and 4.2% vs. 0.4% [OR=9.8], respectively).
Read the article summaryBased on a meta-analysis involving 30 observational studies and 202,965 patients, proton pump inhibitor therapy has been shown to significantly increase the risk of infection with Clostridium difficile (OR = 2.15).
Read the article summaryIn a single institution study involving 424 patients with DM and CRC, those patients treated with metformin had a 30% improvement in OS compared with patients not treated with metformin. Specifically, the metformin-treated patients had a mean survival of 76.9 months compared to 56.9 months.
Read the article summaryIndexed Journals in Gastroenterology: Gastroenterology, American Journal of Gastroenterology, Gut more
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