The latest in Gastroenterology: Ranked summaries of the most clinically-relevant GI literature updated every 24 hours, as well as exclusive content for gastroenterologists. Our team of dedicated physician medical editors sort, rank and summarize articles in over 2,000 medical journals to bring you the key developments in Gastroenterology. In addition to general news, you'll find subspecialty coverage of the biliary system and pancreas, colorectal cancer and polyps, hepatology and liver disease, GI bleeding, GI infectious diseases, gastrointestinal endoscopy, obesity, parenteral and enteral nutrition, diagnostic imaging, and more.
1 Probiotics and antibiotics in IBD Digestive Diseases, January 23, 2015 Clinical Article
2 Chronic liver disease and 90-day mortality in 21359 patients following peptic ulcer bleeding – a Nationwide Cohort Study Alimentary Pharmacology and Therapeutics, January 23, 2015 Clinical Article
3 Optimised empiric triple and concomitant therapy for Helicobacter pylori eradication in clinical practice: the OPTRICON study Alimentary Pharmacology and Therapeutics, January 23, 2015 Clinical Article
4 Effect of colesevelam on faecal bile acids and bowel functions in diarrhoea-predominant irritable bowel syndrome Alimentary Pharmacology and Therapeutics, January 23, 2015 Clinical Article
5 A phase 3 randomized, double-blind, placebo-controlled trial of ganitumab or placebo in combination with gemcitabine as first-line therapy for metastatic adenocarcinoma of the pancreas: The GAMMA trial Annals of Oncology, January 23, 2015 Clinical Article
6 Hepatitis C virus (HCV) antibody positivity and predictors among previously undiagnosed adult primary care outpatients: Cross-sectional analysis of a multi-site retrospective cohort study Clinical Infectious Diseases, January 23, 2015 Clinical Article
7 Terlipressin plus albumin versus midodrine and octreotide plus albumin in the treatment of hepatorenal syndrome: A randomized trial Hepatology, January 23, 2015 Clinical Article
8 Risk of hepatocellular carcinoma in chronic hepatitis B: Assessment and modification with current antiviral therapy Journal of Hepatology, January 23, 2015 Clinical Article
9 National trends of 3- versus 2-stage restorative proctocolectomy for chronic ulcerative colitis Diseases of the Colon and Rectum, January 23, 2015 Review Article
10 General and abdominal obesity and risk of esophageal and gastric adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) International Journal of Cancer, January 23, 2015 Clinical Article
11 Safety of long term biologic therapy in rheumatologic patients with a previously resolved HBV infection Hepatology, January 23, 2015 Clinical Article
12 Patients with chronic hepatitis C without advanced fibrosis and hepatocellular carcinoma: A retrospective clinical?pathological study Digestive and Liver Diseases, January 23, 2015 Clinical Article
13 HIV viraemia during hepatitis B vaccination shortens the duration of protective antibody levels HIV Medicine, January 23, 2015 Clinical Article
14 Deconstructing the differences: A comparison of GBD 2010 and CHERG’s approach to estimating the mortality burden of diarrhea, pneumonia, and their etiologies Full Text BMC Infectious Diseases, January 23, 2015 Clinical Article
15 Multicenter evaluation of the biofire filmarray gastrointestinal panel for the etiologic diagnosis of infectious gastroenteritis Journal of Clinical Microbiology, January 23, 2015 Clinical Article
16 Accuracy of capsule colonoscopy in detecting colorectal polyps in a screening population Gastroenterology, January 23, 2015 Clinical Article
17 The ProPre-save study: effects of probiotics and prebiotics alone or combined on necrotizing enterocolitis in very low birth weight infants The Journal of Pediatrics, January 23, 2015 Clinical Article
18 A clinicopathological cohort study of liver pathology in 301 patients with HIV/AIDS Hepatology, January 23, 2015 Clinical Article
19 Posaconazole: a review of the gastro-resistant tablet and intravenous solution in invasive fungal infections Drugs, January 23, 2015 Review Article
20 Small-molecule inhibitors prevent the genotoxic and protumoural effects induced by colibactin-producing bacteria Gut, January 23, 2015 Clinical Article
As reported in the Journal of Gastroenterology & Hepatology, SCCA-IgM levels are elevated in patients with hepatocellular carcinoma (HCC) compared to patients with cirrhosis and healthy controls. Not only does the SCCA-IgM level predict overall and progression-free survival in HCC patients, but the sensitivity of SCCA-IgM in patients with HCC was 2-fold greater than AFP. A decline in SCCA-IgM levels was shown to be associated with response to treatment.
As reported in the Journal of Crohn’s & Colitis, treatment of corticosteroid-refractory ulcerative colitis patients with 3 doses of infliximab (n=113) resulted in short- (3 months) and long-term (12 months) colectomy rates of 18.6% and 25.6%, respectively. The RR of colectomy in patients with an elevated CRP and severe endoscopic lesions was 2.15 and 5.13, respectively.
Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.
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