1Managing paediatric acute severe ulcerative colitis according to the 2011 ECCO-ESPGHAN guidelines: Efficacy of infliximab as a rescue therapyDigestive and Liver Diseases  Clinical Article
2High treatment modification rates with lamivudine therapy in HBV infected patients with low baseline viremia and early virologic response: A multicenter studyJournal of Digestive Diseases  Clinical Article
3Risk of microangiopathy in type 2 diabetes mellitus patients with or without chronic hepatitis C: Results of a retrospective long-term controlled cohort studyDigestive and Liver Diseases  Clinical Article
4Prospective, comparative effectiveness trial of cows milk elimination and swallowed fluticasone for pediatric eosinophilic esophagitisDiseases of the Esophagus  Clinical Article
5Azithromycin in early infancy and pyloric stenosisPediatrics  Clinical Article
6Oxidative balance scores and risk of incident colorectal cancer in a US prospective cohort studyAmerican Journal of Epidemiology  Clinical Article
7A case study of a hepatitis B screening and blood pressure assesment program in Los Angeles County, 2012–2013Preventing Chronic Disease  Full Text  Review Article
8The impact of human papillomavirus infection on the survival and treatment response of patients with esophageal cancersJournal of Digestive Diseases  Clinical Article
9Sarcopenia, intramuscular fat deposition, and visceral adiposity independently predict the outcomes of hepatocellular carcinomaJournal of Hepatology  Clinical Article
10Response of serum alpha-fetoprotein to entecavir therapy predicts risk for hepatocellular carcinoma in patients with chronic hepatitis BJournal of Gastroenterology and Hepatology  Clinical Article
1Standardization and simplification is key to helping NICU babies feed and growNationwide Children's Hospital
2Published outcomes announced from study on adolescent bariatric surgery safetyNationwide Children's Hospital
3New study details burden of C. diff in U.S.University of Rochester Medical Center
4Reducing disparities in colon cancer through integrated careKaiser Permanente Health Research News
5Use of new systemic adjuvant therapy in gastrointestinal tumors (GITSs) increasing, leading to better survivalAmerican Cancer Society News
6Daclatasvir for hepatitis C: Hint of added benefit in genotype 4German Institute for Quality and Efficiency in Health Care (IQWiG)
7In lab research, SLU team halts NASH liver damageSaint Louis University Health News
8QMUL and Takeda announce research collaboration to develop new therapies in gastroenterologyQueen Mary University of London News
9Researchers find link between inflammation, tissue regeneration and wound repair responseUC San Diego Health System
10Crohn's disease not exempt from racial disparitiesNationwide Children's Hospital

Show Me:

Risk factors for CHC-related death identified

As reported in the World Journal of Gastroenterology, the following risk factors for chronic hepatitis C (CHC)-related deaths have been identified (n=8250 CHC patients; n=144 CHC-related deaths): α-IFN therapy (AOR=0.53); liver cirrhosis (AOR=2.89); hepatocellular carcinoma versus CHC (AOR=8.82); hypertension (AOR=1.76); alcohol consumption (AOR=1.73); and HBsAg positivity (AOR=22.28).

Elevated ?-GT predicts HCC in hepatitis C patients with sustained response

As reported in the Journal of Hepatology, an elevated baseline ɣ-GT level is the strongest predictor of developing HCC in non-cirrhotic patients with hepatitis C and a sustained virologic response (HR = 6.44), followed by age (HR = 3.68).

KIT mutations associated with poor prognosis in GISTs

Based on a meta-analysis (18 studies; n=1487) reported in the World Journal of Surgical Oncology, KIT mutations in patients with gastrointestinal stromal tumors (GISTs) are associated with larger tumors (> 5 cm), higher mitotic activity (> 5), more frequent recurrences (OR = 2.06), more frequent metastases (OR = 2.77), and worse 3-year overall survival (OR = 0.47) compared to patients with PDGFRA mutations or wild-type.

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Clinical Pearls

Clinical Pearl from Smartest DocTriple-therapy with high-dose PPI, amoxicillin and doxycycline is not effective in eradicating multidrug-resistant H. pylori.

Clinical Pearl from Smartest DocPediatric appendicitis patients with SIRS may be at greater risk for intra-abdominal abscesses.

Clinical Pearl from Smartest DocMicroRNAs are known as translational regulators of tumor suppressor or oncogenes.

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List