We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Effectiveness of probiotic therapy for the prevention of relapse in patients with inactive ulcerative colitisWorld Journal of Gastroenterology, May 29, 2015  Full Text  Clinical Article
2Proton pump inhibitors therapy vs H2 receptor antagonists therapy for upper gastrointestinal bleeding after endoscopy: A meta-analysisWorld Journal of Gastroenterology, May 29, 2015  Full Text  Clinical Article  Evidence Based Medicine
3The efficacy and safety of daclatasvir in the treatment of chronic hepatitis C virus infectionAlimentary Pharmacology and Therapeutics, May 29, 2015  Review Article
4Safety, tolerability, and efficacy of oxaliplatin-based adjuvant chemotherapy after curative resection of hepatic or extrahepatic metastases of Stage IV colorectal cancerCancer Chemotherapy and Pharmacology, May 29, 2015  Clinical Article
5Phase II study of capecitabine and the oral mTOR inhibitor everolimus in patients with advanced pancreatic cancerCancer Chemotherapy and Pharmacology, May 29, 2015  Clinical Article
6Changing 14-year trends in the epidemiology of hepatitis B virus infection in rural and urban Central–Eastern European areasJournal of Viral Hepatitis, May 29, 2015  Clinical Article
7Prevention of liver cancer through the early detection of risk-related behavior among hepatitis B or C carriersCancer Nursing, May 29, 2015  Clinical Article
8Comparison of liver transplant-related survival benefit in patients with vs without hepatocellular carcinoma in the United StatesGastroenterology, May 29, 2015  Clinical Article
9Association of type 2 diabetes mellitus and the risk of colorectal cancer: A meta-analysis and systematic reviewWorld Journal of Gastroenterology, May 29, 2015  Full Text  Evidence Based Medicine  Review Article
10Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-upGut, May 29, 2015  Clinical Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1FDA approves two therapies to treat IBS-DFDA Press Announcements, May 29, 2015
2Researchers developing new targeted and immune therapies for colorectal cancer molecular subtypesFox Chase Cancer Center News, May 29, 2015
3Diagnosing cancer with help from bacteriaMassachusetts Institute of Technology Research News, May 29, 2015
4Complex signaling between blood and stem cells controls regeneration in fly gutBuck Institute for Research on Aging News, May 28, 2015
5University Hospital of Bellvitge uses a new app for patients with inflammatory bowel diseaseIDIBELL-Bellvitge Biomedical Research Institute News, May 28, 2015
6Research News Tpl2 enzyme may be target for treating autoimmune diseasesUniversity of Georgia Research News, May 27, 2015
7New demonstration project links colorectal cancer screening to discussion and testing for hepatitis CAmerican College of Gastroenterology News, May 27, 2015
8Researchers discover tumor molecule that causes spread of pancreatic cancerFred Hutchinson Cancer Research Center News, May 26, 2015
9In study, skipping meals is linked to abdominal weight gainOhio State University News, May 21, 2015
10Helping doctors predict what's next for patients diagnosed with Hepatitis CUniversity of Michigan Health System, May 21, 2015

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SCCA-IgM predicts survival in HCC patients

As reported in the Journal of Gastroenterology & Hepatology, SCCA-IgM levels are elevated in patients with hepatocellular carcinoma (HCC) compared to patients with cirrhosis and healthy controls. Not only does the SCCA-IgM level predict overall and progression-free survival in HCC patients, but the sensitivity of SCCA-IgM in patients with HCC was 2-fold greater than AFP. A decline in SCCA-IgM levels was shown to be associated with response to treatment.

Predictors of sustained binge drinking

As reported in Alcoholism: Clinical & Experimental Research, sustained binge drinkers have an earlier onset, drink monthly in secondary school, binged in their 20s, exhibit impulsivity and novelty-seeking, and have depressive symptoms during adolescence compared to those who stop binge drinking.

SIRT3 expression improves prognosis in gastric cancer

As reported in the World Journal of Surgery, SIRT3 expression improves the prognosis in patients with gastric cancer (n=221). Specifically, the 5-year OS was 51.2% and 39.1% in patients who do and do not express SIRT3, respectively. The 5-year DFS was 49.6% and 38.0% in patients who do and do not express SIRT3, respectively. Patients who do not express SIRT3 are characterized by increased poor cellular differentiation, increased diffuse-type Lauren’s histology, and increases scirrhous-type stromal reactions, suggesting the SIRT3 functions as a tumor suppressor.

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Clinical Pearls

Clinical Pearl from Smartest DocSuccessful biliary cannulation can be achieved during ERCP using a sequential protocol.

Clinical Pearl from Smartest DocVigilance and screening for NMSC is recommended in patients being treated for IBD.

Clinical Pearl from Smartest DocEnteral glucose ingestion results in acutely lowering of serum testosterone levels.

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