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The role of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) as a prognostic marker in older people: the impact of reduced renal function
Reviews in Clinical Gerontology, 11/10/09

Axelsson TG et al. – The N–terminal pro–brain natriuretic peptide (NT–pro–BNP) is released in response to volume expansion and/or increased tension on left ventricular myocytes. NT–pro–BNP is a useful diagnostic and prognostic biomarker both in patients with dyspnoea of unknown aetiology, and for risk assessment of patients with established heart failure. However, impaired kidney function – a common condition in older people as well as a strong risk factor for cardiovascular disease is associated with elevated circulating levels of NT–pro–BNP. Therefore, it is important to know the kidney function when interpreting an elevated NT–pro–BNP measurement obtained in older people in order to diagnose or stage congestive heart failure.

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