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Update on the Management of Pain in Arthritis and the Use of Cyclooxygenase-2 Inhibitors
Current Pain and Headache Reports, 11/06/09

Ross E – Chronic pain from arthritis continues to be one of the biggest causes of disability and loss of function in the United States today. This is still the case despite many new insights into the pathophysiology of pain, effective treatment approaches, and new, safer medications that can be used long–term. There are many different types of arthritic problems. New disease–modifying agents that are available for some of these types of arthritic diseases, such as rheumatoid arthritis, have the potential to have a substantial impact on improvement in the long–term prognosis. Despite this optimistic outlook, pain often is a significant problem and should be treated whenever it becomes a barrier to function. To complicate treatment for this condition, the most widely used group of medications is under new scrutiny because of concerns regarding long–term detrimental side effects. A complete understanding of the risk factors for NSAIDs, specifically cyclooxygenase–2 inhibitors, is still not available. But published data and new clinical guidelines still suggest that treatment for this large category of diseases can be effective and safe.

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Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids
Pain, 11/02/09 Relevance Score: 88%

Celecoxib in arthritis: relative risk management profile and implications for patients
Therapeutics and Clinical Risk Management, 11/10/09 Relevance Score: 87%

Medical decision making in patients with knee pain, meniscal tear, and osteoarthritis
Arthritis Care and Research, 11/04/09 Relevance Score: 81%

Gastrointestinal Safety of Nonsteroidal Antiinflammatory Drugs and Selective Cyclooxygenase-2 Inhibitors in Patients on Warfarin
Annals of Pharmacotherapy, 10/13/09 Relevance Score: 81%

Bradykinin receptor antagonists and cyclooxygenase inhibitors in vincristine and streptozotocin-induced hyperalgesia
Pharmacological Reports, 10/12/09 Relevance Score: 81%