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Kosek E – Convincing evidence of a dysfunction of pain modulation has been presented in FM and treatments known to modify these mechanisms have pain–relieving effects. However, current treatments are only effective in a limited number of FM patients and this is most likely to be owing to the heterogeneous nature of FM. Mechanistic studies are needed to identify profiles of FM patients, characterizing likely responders with the various treatments. Furthermore, the mechanisms of action of nonpharmacological treatments need to be clarified.

   

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